DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdb and ppp2r5b

DIOPT Version :9

Sequence 1:	NP_001368946.1	Gene:	wdb / 43312	FlyBaseID:	FBgn0027492	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	XP_021333478.1	Gene:	ppp2r5b / 562282	ZFINID:	ZDB-GENE-101208-1	Length:	503	Species:	Danio rerio

Alignment Length:	504	Identity:	331/504 - (65%)
Similarity:	403/504 - (79%)	Gaps:	18/504 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 TETAIDSNEPKSEKMSSGTFV---DRIDPFAKRSLKK-KGKKSQGSSRYR-NSQDVELQQLPPLK 231
            |.|.:..:.|.|.  ::|..|   :::|.|.:||::: :.::|..||::| .|..|||..||.||
Zfish     3 TPTKLPPSSPSSP--TTGFSVPSAEKVDGFPRRSMRRARQRRSHSSSQFRYQSSQVELTPLPLLK 65

  Fly   232 ADCSSLEQEELFIRKLRQCCVSFDFMDPVTDLKGKEIKRAALNDLSTYITHGRGVLTEPVYPEII 296
             |....|..:||.:||:||||.|||:|.|.|||||||||||||:|...:...||||.||:|||.|
Zfish    66 -DAPVAELHDLFCKKLQQCCVLFDFLDCVADLKGKEIKRAALNELVESVATSRGVLIEPLYPEAI 129

  Fly   297 RMISCNLFRTLPPSENPDFDPEEDDPTLEASWPHLQLVYEVFLRFLESQDFQATIGKRVIDQKFV 361
            :|||.|:||||||||||:||||||:|.|||||||||||||.|||||||.|||.::.||.:|||||
Zfish   130 KMISVNIFRTLPPSENPEFDPEEDEPALEASWPHLQLVYEFFLRFLESPDFQPSLAKRYVDQKFV 194

  Fly   362 LQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVGELLEILG 426
            |||||||||||||||::|||:|||:|||.|||||:|||||||||||||||||.||||.|||||||
Zfish   195 LQLLELFDSEDPREREYLKTILHRVYGKLLGLRAYIRKQINNIFLRFIYETERFNGVAELLEILG 259

  Fly   427 SIINGFALPLKAEHKQFLVKVLLPLHKVKCLSLYHAQLAYCIVQFLEKDPFLTEPVVRGLLKFWP 491
            |||||||||||:|||||||:||:|||..|.||::|||||||:|||:|||..:||.::||||::||
Zfish   260 SIINGFALPLKSEHKQFLVRVLIPLHTAKSLSIFHAQLAYCVVQFMEKDATVTEHIIRGLLRYWP 324

  Fly   492 KTCSQKEVMFLGEIEEILDVIDPPQFVKIQEPLFRQIAKCVSSPHFQVAERALYLWNNEYAMSLI 556
            |||:|||||||||||||||||:|.||:::|||||:|||.|:|||||||||||||.|||||.:|||
Zfish   325 KTCTQKEVMFLGEIEEILDVIEPSQFIRVQEPLFKQIAACISSPHFQVAERALYFWNNEYILSLI 389

  Fly   557 EENNAVIMPIMFPALYRISKEHWNQTIVALVYNVLKTFMEMNSKLFDELTSSYKAERQKEKKRER 621
            |||..||:|::|..|||:|||||||||::|:||||||||||||||||:||:|||.|:|||.|:||
Zfish   390 EENCQVILPLVFGTLYRVSKEHWNQTIISLIYNVLKTFMEMNSKLFDDLTASYKVEKQKELKKER 454

  Fly   622 DREELWKKLHELESNRSSGRTAGG----------SATTSNSAASAASTS 660
            :|.|||:.|.:|...|....|...          :...|.|..|||:|:
Zfish   455 ERVELWRNLEDLRERRLQSLTEASRNQKNLQERENTAKSQSDTSAANTT 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdb	NP_001368946.1	B56	235..633	CDD:396263	299/397 (75%)
ppp2r5b	XP_021333478.1	B56	66..466	CDD:307642	300/399 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592744
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	701	1.000	Inparanoid score	I648
OMA	1	1.010	-	-		QHG54502
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	1	1.000	-	-		otm24530
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	1	1.100	-	-	O	PTHR10257
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.890