DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdb and ppp2r5cb

DIOPT Version :9

Sequence 1:	NP_001368946.1	Gene:	wdb / 43312	FlyBaseID:	FBgn0027492	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001038286.2	Gene:	ppp2r5cb / 557208	ZFINID:	ZDB-GENE-041014-4	Length:	578	Species:	Danio rerio

Alignment Length:	491	Identity:	322/491 - (65%)
Similarity:	377/491 - (76%)	Gaps:	28/491 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 ETAIDSNEPKSEKMSSGTFVDRID-------------PFAKRSLKKKGKKSQ---------GSSR 215
            :|..|.:.|||.|:......:..:             |.|.:.||.|...||         .|||
Zfish     4 KTKKDKDSPKSAKVGKTAGQENSEHEQASNKKGGNSVPPATQLLKGKQSGSQTPVKKEKRPNSSR 68

  Fly   216 YRNSQDVELQQLPPLKADCSSLEQEELFIRKLRQCCVSFDFM-DPVTDLKGKEIKRAALNDLSTY 279
            :..|.:.|||:| |:..|....|||:||::|||||||.|||: ||::|||.||:|||||:::..|
Zfish    69 FSLSNNRELQKL-PVFTDVPPAEQEKLFVQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEY 132

  Fly   280 ITHGRGVLTEPVYPEIIRMISCNLFRTLPPSENP---DFDPEEDDPTLEASWPHLQLVYEVFLRF 341
            |||.|.|:|||:|||::.|.:.|:|||||||.||   :||||||:|||||:|||||||||.||||
Zfish   133 ITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRF 197

  Fly   342 LESQDFQATIGKRVIDQKFVLQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFL 406
            |||.|||..|.|:.||||||||||||||||||||||||||.|||||||||||||:|||||||||.
Zfish   198 LESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFY 262

  Fly   407 RFIYETEHFNGVGELLEILGSIINGFALPLKAEHKQFLVKVLLPLHKVKCLSLYHAQLAYCIVQF 471
            ||||||||.||:.||||||||||||||||||.|||.||:||||||||||.||:||.|||||:|||
Zfish   263 RFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQF 327

  Fly   472 LEKDPFLTEPVVRGLLKFWPKTCSQKEVMFLGEIEEILDVIDPPQFVKIQEPLFRQIAKCVSSPH 536
            ||||..||||||..|||:||||.|.||||||.|:|||||||:|.:|||:.||||||:||||||||
Zfish   328 LEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKVMEPLFRQLAKCVSSPH 392

  Fly   537 FQVAERALYLWNNEYAMSLIEENNAVIMPIMFPALYRISKEHWNQTIVALVYNVLKTFMEMNSKL 601
            |||||||||.|||||.||||.:|.|.|:|||||:|||.||.|||:||..|:||.||.|||||.||
Zfish   393 FQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKL 457

  Fly   602 FDELTSSYKAERQKEKKRERDREELWKKLHEL-ESN 636
            ||:.|..::||:.|||.:.::|||.|.|:..| :||
Zfish   458 FDDCTQQFRAEKNKEKAKWKEREEAWIKIENLAKSN 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdb	NP_001368946.1	B56	235..633	CDD:396263	296/401 (74%)
ppp2r5cb	NP_001038286.2	PLN00122	33..>146	CDD:215064	53/113 (47%)
		B56	87..490	CDD:279883	296/402 (74%)
		PLN00122	<395..496	CDD:215064	62/99 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54502
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760