DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdb and PPP2R5E

DIOPT Version :9

Sequence 1:	NP_001368946.1	Gene:	wdb / 43312	FlyBaseID:	FBgn0027492	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001269108.1	Gene:	PPP2R5E / 5529	HGNCID:	9313	Length:	467	Species:	Homo sapiens

Alignment Length:	452	Identity:	345/452 - (76%)
Similarity:	401/452 - (88%)	Gaps:	3/452 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 VDRIDPFAKRSLKK-KGKKSQGSSRYRN-SQDVELQQLPPLKADCSSLEQEELFIRKLRQCCVSF 254
            ||::|.|:::|::| :.|:||.||::|: .:.:||..||.|| |..|.||.|||::||:||||.|
Human    11 VDKVDGFSRKSVRKARQKRSQSSSQFRSQGKPIELTPLPLLK-DVPSSEQPELFLKKLQQCCVIF 74

  Fly   255 DFMDPVTDLKGKEIKRAALNDLSTYITHGRGVLTEPVYPEIIRMISCNLFRTLPPSENPDFDPEE 319
            ||||.::|||.||.||:.||:|..|||..||.|||..|||::||:|||:|||||||::.:|||||
Human    75 DFMDTLSDLKMKEYKRSTLNELVDYITISRGCLTEQTYPEVVRMVSCNIFRTLPPSDSNEFDPEE 139

  Fly   320 DDPTLEASWPHLQLVYEVFLRFLESQDFQATIGKRVIDQKFVLQLLELFDSEDPRERDFLKTVLH 384
            |:|||||||||||||||.|:||||||:||.:|.|:.||||||||||||||||||||||:||||||
Human   140 DEPTLEASWPHLQLVYEFFIRFLESQEFQPSIAKKYIDQKFVLQLLELFDSEDPRERDYLKTVLH 204

  Fly   385 RIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVGELLEILGSIINGFALPLKAEHKQFLVKVLL 449
            ||||||||||||||||||||||||:|||||||||.|||||||||||||||||||||||||||||:
Human   205 RIYGKFLGLRAFIRKQINNIFLRFVYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLVKVLI 269

  Fly   450 PLHKVKCLSLYHAQLAYCIVQFLEKDPFLTEPVVRGLLKFWPKTCSQKEVMFLGEIEEILDVIDP 514
            |||.|:.|||:||||||||||||||||.|||||:|||:|||||||||||||||||:|||||||:|
Human   270 PLHTVRSLSLFHAQLAYCIVQFLEKDPSLTEPVIRGLMKFWPKTCSQKEVMFLGELEEILDVIEP 334

  Fly   515 PQFVKIQEPLFRQIAKCVSSPHFQVAERALYLWNNEYAMSLIEENNAVIMPIMFPALYRISKEHW 579
            .||||||||||:|||||||||||||||||||.|||||.|||||||:.||:||||.:|||||||||
Human   335 SQFVKIQEPLFKQIAKCVSSPHFQVAERALYYWNNEYIMSLIEENSNVILPIMFSSLYRISKEHW 399

  Fly   580 NQTIVALVYNVLKTFMEMNSKLFDELTSSYKAERQKEKKRERDREELWKKLHELESNRSSGR 641
            |..||||||||||.||||||.:|||||::||::||:|||:|::||||||||.:||..|...|
Human   400 NPAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQREKKKEKEREELWKKLEDLELKRGLRR 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdb	NP_001368946.1	B56	235..633	CDD:396263	322/397 (81%)
PPP2R5E	NP_001269108.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		12/28 (43%)
		B56	2..>67	CDD:421517	25/56 (45%)
		B56	55..435	CDD:396263	309/379 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157058
Domainoid	1	1.000	676	1.000	Domainoid score	I140
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55962
Inparanoid	1	1.050	706	1.000	Inparanoid score	I662
Isobase	1	0.950	-	0	Normalized mean entropy	S316
OMA	1	1.010	-	-		QHG54502
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	1	1.000	-	-		otm41827
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	1	1.100	-	-	O	PTHR10257
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720