Protein Alignment wdb and PPP2R5D

DIOPT Version :10

• Sequence 1: NP_001368946.1
• Gene: wdb / 43312
• FlyBaseID: FBgn0027492
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: NP_006236.1
• Gene: PPP2R5D / 5528
• HGNCID: 9312
• Length: 602
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 325/495 - (65%)
• Similarity: 384/495 - (77%)
• Gaps: 18/495 - (3%)

  Fly   154 PVASVKNKAGKLNT------TQTATETAIDSNEPKSEKMSSG-----TFVDRIDPFAKRSLKKKG 207
            |.:|.|:..|: ||      .|...:....|..|.|.|..|.     |.:.:|.......:.||
Human    21 PSSSGKDGGGE-NTEEAQPQPQPQPQPQAQSQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKK- 83

  Fly   208 KKSQGSSRYRNSQDVELQQLPPLKADCSSLEQEELFIRKLRQCCVSFDFM-DPVTDLKGKEIKRA 271
            ::.|.|||:..|::.|||:||.|| |..:.|:|||||:|||||||.|||: ||::|||.||:|||
Human    84 ERRQSSSRFNLSKNRELQKLPALK-DSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRA 147

  Fly   272 ALNDLSTYITHGRGVLTEPVYPEIIRMISCNLFRTLPPSENP---DFDPEEDDPTLEASWPHLQL 333
            .||::..||||.|.|:||.:|||.:.|.|.|||||||||.||   :||||||:|||||:||||||
Human   148 GLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQL 212

  Fly   334 VYEVFLRFLESQDFQATIGKRVIDQKFVLQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIR 398
            |||.|||||||.|||..|.|:.|||||||.||:|||||||||||||||:|||||||||||||:||
Human   213 VYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIR 277

  Fly   399 KQINNIFLRFIYETEHFNGVGELLEILGSIINGFALPLKAEHKQFLVKVLLPLHKVKCLSLYHAQ 463
            :|||:||.||||||||.||:.||||||||||||||||||.|||.||::|||||||||.||:||.|
Human   278 RQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQ 342

  Fly   464 LAYCIVQFLEKDPFLTEPVVRGLLKFWPKTCSQKEVMFLGEIEEILDVIDPPQFVKIQEPLFRQI 528
            ||||:||||||:..|||||:.|||||||||.|.||||||.|:|||||||:|.:|.|:.||||||:
Human   343 LAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQL 407

  Fly   529 AKCVSSPHFQVAERALYLWNNEYAMSLIEENNAVIMPIMFPALYRISKEHWNQTIVALVYNVLKT 593
            |||||||||||||||||.|||||.||||.:|.|.::|||||||||.||.|||:||..|:||.||.
Human   408 AKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKL 472

  Fly   594 FMEMNSKLFDELTSSYKAERQKEKKRERDREELWKKLHEL 633
            |||||.||||:.|..||||:||.:.|.::|||:|:|:.||
Human   473 FMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEEL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wdb	NP_001368946.1	B56	235..633	CDD:460264	294/401 (73%)
PPP2R5D	NP_006236.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		20/76 (26%)
		8 X 2 AA approximate tandem repeats of Q-P	37..52		2/14 (14%)
		B56	56..>122	CDD:474937	25/67 (37%)
		B56	110..513	CDD:460264	296/403 (73%)
		SH3-binding, class I. /evidence=ECO:0000255	523..530
		Nuclear localization signal. /evidence=ECO:0000255	548..565