DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdb and PPP2R5B

DIOPT Version :9

Sequence 1:	NP_001368946.1	Gene:	wdb / 43312	FlyBaseID:	FBgn0027492	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_006235.1	Gene:	PPP2R5B / 5526	HGNCID:	9310	Length:	497	Species:	Homo sapiens

Alignment Length:	497	Identity:	329/497 - (66%)
Similarity:	393/497 - (79%)	Gaps:	7/497 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 QTATETAIDSNEPKSEKMSSGTFVDRIDPFAKRSLKK-KGKKSQGSSRYR-NSQDVELQQLPPLK 231
            :|....|.....|.|..:|.....|::|.|::|||:: :.::|..||::| .|...||..||.||
Human     2 ETKLPPASTPTSPSSPGLSPVPPPDKVDGFSRRSLRRARPRRSHSSSQFRYQSNQQELTPLPLLK 66

  Fly   232 ADCSSLEQEELFIRKLRQCCVSFDFMDPVTDLKGKEIKRAALNDLSTYITHGRGVLTEPVYPEII 296
             |..:.|..||..|||.||.|.|||:|.|.||||||:||||||:|...:...||||.|||||:||
Human    67 -DVPASELHELLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDII 130

  Fly   297 RMISCNLFRTLPPSENPDFDPEEDDPTLEASWPHLQLVYEVFLRFLESQDFQATIGKRVIDQKFV 361
            ||||.|:||||||||||:||||||:|.||.||||||||||.|||||||.|||.::.||.:|||||
Human   131 RMISVNIFRTLPPSENPEFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFV 195

  Fly   362 LQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVGELLEILG 426
            |.|||||||||||||::|||:|||:|||||||||:||||.|:||||||||.||||||.|||||||
Human   196 LMLLELFDSEDPREREYLKTILHRVYGKFLGLRAYIRKQCNHIFLRFIYEFEHFNGVAELLEILG 260

  Fly   427 SIINGFALPLKAEHKQFLVKVLLPLHKVKCLSLYHAQLAYCIVQFLEKDPFLTEPVVRGLLKFWP 491
            |||||||||||.|||||||:||:|||.||.||::|||||||:|||||||..|||.|:|||||:||
Human   261 SIINGFALPLKTEHKQFLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWP 325

  Fly   492 KTCSQKEVMFLGEIEEILDVIDPPQFVKIQEPLFRQIAKCVSSPHFQVAERALYLWNNEYAMSLI 556
            |||:|||||||||:|||||||:|.||||||||||:|:|:|||||||||||||||.|||||.:|||
Human   326 KTCTQKEVMFLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLI 390

  Fly   557 EENNAVIMPIMFPALYRISKEHWNQTIVALVYNVLKTFMEMNSKLFDELTSSYKAERQKEKKRER 621
            |:|...::|.:|..||::||||||||||:|:|||||||||||.|||||||:|||.|:|:|:::.:
Human   391 EDNCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQEQQKAQ 455

  Fly   622 DREELWKKLHELESNRSSGRTAGGSA----TTSNSAASAAST 659
            :|:|||:.|.||...|..|......|    .|...|||...:
Human   456 ERQELWQGLEELRLRRLQGTQGAKEAPLQRLTPQVAASGGQS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdb	NP_001368946.1	B56	235..633	CDD:396263	297/397 (75%)
PPP2R5B	NP_006235.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		15/52 (29%)
		B56	69..467	CDD:279883	297/397 (75%)
		PLN00122	<373..467	CDD:215064	61/93 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..497		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54502
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	1	1.100	-	-	O	PTHR10257
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.750