DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdb and ppp2r5d

DIOPT Version :9

Sequence 1:	NP_001368946.1	Gene:	wdb / 43312	FlyBaseID:	FBgn0027492	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_998483.1	Gene:	ppp2r5d / 406610	ZFINID:	ZDB-GENE-040426-2568	Length:	601	Species:	Danio rerio

Alignment Length:	492	Identity:	325/492 - (66%)
Similarity:	384/492 - (78%)	Gaps:	23/492 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 ASVKN---KAGKLNTTQTATETAIDSNEPKSEKMSSGTFVDRIDPFAKRSLKKKG-------KKS 210
            :|.||   .|||    ...||.:.::.:..|::.|:.|    ..|.....:|..|       ::.
Zfish    17 SSTKNSNASAGK----DVGTENSEEAQQTASKRPSNST----PPPTQLNKIKYSGGPQIVKKERR 73

  Fly   211 QGSSRYRNSQDVELQQLPPLKADCSSLEQEELFIRKLRQCCVSFDFM-DPVTDLKGKEIKRAALN 274
            |.|||:..|::.|||:||.|| |...:::||||::|||||||.|||: ||::|||.||:|||.||
Zfish    74 QSSSRFNLSKNRELQKLPALK-DAPPIDREELFVQKLRQCCVLFDFVTDPLSDLKYKEVKRAGLN 137

  Fly   275 DLSTYITHGRGVLTEPVYPEIIRMISCNLFRTLPPSENP---DFDPEEDDPTLEASWPHLQLVYE 336
            ::..||||.|.|:||.:|||.:.|.|.|||||||||.||   :||||||:|||||:|||||||||
Zfish   138 EMVEYITHNRDVVTESIYPEAVIMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYE 202

  Fly   337 VFLRFLESQDFQATIGKRVIDQKFVLQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQI 401
            .|||||||.|||..|.|:.|||||||.||||||||||||||||||:|||||||||||||:||:||
Zfish   203 FFLRFLESPDFQPNIAKKYIDQKFVLSLLELFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQI 267

  Fly   402 NNIFLRFIYETEHFNGVGELLEILGSIINGFALPLKAEHKQFLVKVLLPLHKVKCLSLYHAQLAY 466
            ||||.||||||||.||:.||||||||||||||||||.|||.||::|||||||||.||:||.||||
Zfish   268 NNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAY 332

  Fly   467 CIVQFLEKDPFLTEPVVRGLLKFWPKTCSQKEVMFLGEIEEILDVIDPPQFVKIQEPLFRQIAKC 531
            |:|||||||..|||||:.|||||||||.|.||||||.|:|||||||:|.:|||:.||||||:|||
Zfish   333 CVVQFLEKDSSLTEPVIMGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFVKVMEPLFRQLAKC 397

  Fly   532 VSSPHFQVAERALYLWNNEYAMSLIEENNAVIMPIMFPALYRISKEHWNQTIVALVYNVLKTFME 596
            ||||||||||||||.|||||.||||.:|.|.|:||||||||:.||.|||:||..|:||.||.|||
Zfish   398 VSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPALYKNSKSHWNKTIHGLIYNALKLFME 462

  Fly   597 MNSKLFDELTSSYKAERQKEKKRERDREELWKKLHEL 633
            ||.||||:.|..||||:||||.:.::|||:|.|:..|
Zfish   463 MNQKLFDDCTQQYKAEKQKEKYKVKEREEMWHKIEAL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdb	NP_001368946.1	B56	235..633	CDD:396263	297/401 (74%)
ppp2r5d	NP_998483.1	PLN00122	43..>156	CDD:215064	53/117 (45%)
		B56	97..500	CDD:279883	298/403 (74%)
		PLN00122	<405..507	CDD:215064	63/95 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54502
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830