DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdb and ppp2r5ea

DIOPT Version :9

Sequence 1:	NP_001368946.1	Gene:	wdb / 43312	FlyBaseID:	FBgn0027492	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_919396.1	Gene:	ppp2r5ea / 373881	ZFINID:	ZDB-GENE-030904-7	Length:	468	Species:	Danio rerio

Alignment Length:	465	Identity:	335/465 - (72%)
Similarity:	397/465 - (85%)	Gaps:	5/465 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 SEKMSSGTFVDRIDPFAKRSLKK-KGKKSQGSSRYRNSQD--VELQQLPPLKADCSSLEQEELFI 244
            |...::...||::|.|:::|::| :.|::|.||::| |||  :||..||.|| |.|:.||.|||:
Zfish     2 SSAATTAPSVDKVDGFSRKSVRKARQKRAQSSSQFR-SQDKPIELVALPLLK-DVSAQEQPELFL 64

  Fly   245 RKLRQCCVSFDFMDPVTDLKGKEIKRAALNDLSTYITHGRGVLTEPVYPEIIRMISCNLFRTLPP 309
            :||:|||..|||||.::|||.||.||:.||:|..|:|..||.|||..|||:::|:|.|:||||||
Zfish    65 KKLQQCCTLFDFMDTLSDLKMKEYKRSTLNELVDYVTLSRGYLTEQTYPEVVKMVSYNIFRTLPP 129

  Fly   310 SENPDFDPEEDDPTLEASWPHLQLVYEVFLRFLESQDFQATIGKRVIDQKFVLQLLELFDSEDPR 374
            |::.:||||||:|||||||||||||||.|:||||||:||.:..|:.|||||||||||||||||||
Zfish   130 SDSNEFDPEEDEPTLEASWPHLQLVYEFFIRFLESQEFQPSAAKKYIDQKFVLQLLELFDSEDPR 194

  Fly   375 ERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVGELLEILGSIINGFALPLKAE 439
            |||.||||||||||||||||||||||||||||.|:||||.||||.||||||||||||||||||||
Zfish   195 ERDCLKTVLHRIYGKFLGLRAFIRKQINNIFLCFVYETERFNGVAELLEILGSIINGFALPLKAE 259

  Fly   440 HKQFLVKVLLPLHKVKCLSLYHAQLAYCIVQFLEKDPFLTEPVVRGLLKFWPKTCSQKEVMFLGE 504
            |||||||||||||.|:.|||:||||||||||||||||.|||||:|||||||||||||||||||||
Zfish   260 HKQFLVKVLLPLHTVRSLSLFHAQLAYCIVQFLEKDPTLTEPVIRGLLKFWPKTCSQKEVMFLGE 324

  Fly   505 IEEILDVIDPPQFVKIQEPLFRQIAKCVSSPHFQVAERALYLWNNEYAMSLIEENNAVIMPIMFP 569
            :|||||||:|.|||||||.||:|||:|||||||||||||||.|||||.|||||||.:.|:||||.
Zfish   325 LEEILDVIEPTQFVKIQELLFKQIARCVSSPHFQVAERALYYWNNEYIMSLIEENCSAILPIMFA 389

  Fly   570 ALYRISKEHWNQTIVALVYNVLKTFMEMNSKLFDELTSSYKAERQKEKKRERDREELWKKLHELE 634
            :||||||||||..|.||:|||||.||||||.|||||.:|||::||:|:|::::||:||:||.:||
Zfish   390 SLYRISKEHWNPAISALIYNVLKAFMEMNSALFDELAASYKSDRQRERKKDKEREDLWRKLEDLE 454

  Fly   635 SNRSSGRTAG 644
            ..|....:.|
Zfish   455 LRRGIQNSDG 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdb	NP_001368946.1	B56	235..633	CDD:396263	309/397 (78%)
ppp2r5ea	NP_919396.1	PLN00122	2..>67	CDD:215064	28/66 (42%)
		B56	55..453	CDD:279883	309/397 (78%)
		PLN00122	<359..453	CDD:215064	66/93 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592743
Domainoid	1	1.000	670	1.000	Domainoid score	I141
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55962
Inparanoid	1	1.050	701	1.000	Inparanoid score	I648
OMA	1	1.010	-	-		QHG54502
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	1	1.000	-	-		otm24530
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	1	1.100	-	-	O	PTHR10257
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770