DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdb and Ppp2r5a

DIOPT Version :9

Sequence 1:	NP_001368946.1	Gene:	wdb / 43312	FlyBaseID:	FBgn0027492	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_659129.2	Gene:	Ppp2r5a / 226849	MGIID:	2388479	Length:	486	Species:	Mus musculus

Alignment Length:	469	Identity:	345/469 - (73%)
Similarity:	400/469 - (85%)	Gaps:	6/469 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 DRIDPFAKRSLKK--KGKKSQGSSRYRN-SQDVELQQLPPLKADCSSLEQEELFIRKLRQCCVSF 254
            :::|.|.::|::|  :.|:|||||::|: ....||..||.|| |.:|.||:|||.:||:||||.|
Mouse    19 EKVDGFTRKSVRKAQRQKRSQGSSQFRSQGSQAELHPLPQLK-DATSNEQQELFCQKLQQCCVLF 82

  Fly   255 DFMDPVTDLKGKEIKRAALNDLSTYITHGRGVLTEPVYPEIIRMISCNLFRTLPPSENPDFDPEE 319
            ||||.|:|||.||||||.||:|..|::..|||:.|..|.:|::|||.|:|||||||:||||||||
Mouse    83 DFMDSVSDLKSKEIKRATLNELVEYVSTNRGVIVESAYSDIVKMISANIFRTLPPSDNPDFDPEE 147

  Fly   320 DDPTLEASWPHLQLVYEVFLRFLESQDFQATIGKRVIDQKFVLQLLELFDSEDPRERDFLKTVLH 384
            |:|||||||||:|||||.|||||||.|||.:|.||.||||||.||||||||||||||||||||||
Mouse   148 DEPTLEASWPHIQLVYEFFLRFLESPDFQPSIAKRYIDQKFVQQLLELFDSEDPRERDFLKTVLH 212

  Fly   385 RIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVGELLEILGSIINGFALPLKAEHKQFLVKVLL 449
            ||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||:|||:
Mouse   213 RIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLMKVLI 277

  Fly   450 PLHKVKCLSLYHAQLAYCIVQFLEKDPFLTEPVVRGLLKFWPKTCSQKEVMFLGEIEEILDVIDP 514
            |:|..|.|:|:|||||||:|||||||..|||||:|||||||||||||||||||||||||||||:|
Mouse   278 PMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEP 342

  Fly   515 PQFVKIQEPLFRQIAKCVSSPHFQVAERALYLWNNEYAMSLIEENNAVIMPIMFPALYRISKEHW 579
            .||.||:||||:||:|||||.||||||||||.|||||.:||||||...|:||||.:||:||||||
Mouse   343 TQFKKIEEPLFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKILPIMFASLYKISKEHW 407

  Fly   580 NQTIVALVYNVLKTFMEMNSKLFDELTSSYKAERQKEKKRERDREELWKKLHELESNRSSGRTAG 644
            ||||||||||||||.||||.||||:||||||||||:|||:|.:||||||||.||:..::..:.
Mouse   408 NQTIVALVYNVLKTLMEMNGKLFDDLTSSYKAERQREKKKELEREELWKKLEELQLKKALEKQ-- 470

  Fly   645 GSATTSNSAASAAS 658
            .:|...:|..|:.|
Mouse   471 NNAYNMHSIRSSTS 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdb	NP_001368946.1	B56	235..633	CDD:396263	321/397 (81%)
Ppp2r5a	NP_659129.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..52		11/29 (38%)
		B56	64..461	CDD:279883	321/396 (81%)
		PLN00122	<351..466	CDD:215064	90/114 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847463
Domainoid	1	1.000	676	1.000	Domainoid score	I143
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	705	1.000	Inparanoid score	I655
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54502
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	1	1.000	-	-		otm43878
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	1	1.100	-	-	LDO	PTHR10257
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790