DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdb and pptr-1

DIOPT Version :9

Sequence 1:	NP_001368946.1	Gene:	wdb / 43312	FlyBaseID:	FBgn0027492	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_507133.4	Gene:	pptr-1 / 180100	WormBaseID:	WBGene00012348	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	345/566 - (60%)
Similarity:	403/566 - (71%)	Gaps:	46/566 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 GAADQFPVASVKNKA-GKLNTTQTATETAIDSNEPKSEKMSSGTFVDRIDPFAKRSLKKKGKKSQ 211
            ||..|.|....:..| |....:.||.:                 |||:||||..:....:..:..
Worm    10 GAPHQIPPPRTQGAATGGQQLSATANQ-----------------FVDKIDPFHNKRGTSRRLRIN 57

  Fly   212 GSSRYRNSQDVELQQLPPLKADCSSLEQEELFIRKLRQCCVSFDFMDPVTDLKGKEIKRAALNDL 276
            .||||......||.||..:| |.::.||..|.|.||.||...|||.|||..||.|||||||||:|
Worm    58 NSSRYNVDSAQELVQLALIK-DTAANEQPALVIEKLVQCQHVFDFYDPVAQLKCKEIKRAALNEL 121

  Fly   277 STYITHGRGVLTEPVYPEIIRMISCNLFRTLPPSENPDFDPEEDDPTLEASWPHLQLVYEVFLRF 341
            ..:||..:|.:.|.:||.:|:|::.|:||.||||||.:||||||:||||.||||||||||:||||
Worm   122 IDHITSTKGAIVETIYPAVIKMVAKNIFRVLPPSENCEFDPEEDEPTLEVSWPHLQLVYELFLRF 186

  Fly   342 LESQDFQATIGKRVIDQKFVLQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFL 406
            |||.||||:|||:.|||:|||:||:|||||||||||||||||||||||||||||||||.|||:||
Worm   187 LESPDFQASIGKKYIDQRFVLKLLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKHINNMFL 251

  Fly   407 RFIYETEHFNGVGELLEILGSIINGFALPLKAEHKQFLVKVLLPLHKVKCLSLYHAQLAYCIVQF 471
            ||:|||:.|||||||||||||||||||||||.|||.|||||||||||.|||||||||||||:|||
Worm   252 RFVYETDSFNGVGELLEILGSIINGFALPLKQEHKVFLVKVLLPLHKPKCLSLYHAQLAYCVVQF 316

  Fly   472 LEKDPFLTEPVVRGLLKFWPKTCSQKEVMFLGEIEEILDVIDPPQFVKIQEPLFRQIAKCVSSPH 536
            :|||..||..|...||||||:|||.||||||||:|||||:|:|.||.||.:|||||:||||||||
Worm   317 IEKDSSLTPQVFEALLKFWPRTCSSKEVMFLGEVEEILDIIEPEQFKKIIDPLFRQLAKCVSSPH 381

  Fly   537 FQVAERALYLWNNEYAMSLIEENNAVIMPIMFPALYRISKEHWNQTIVALVYNVLKTFMEMNSKL 601
            |||||||||.|||||.:||||:.::::|||||||||||||||||||||||||||||||||||.||
Worm   382 FQVAERALYFWNNEYILSLIEDTSSLVMPIMFPALYRISKEHWNQTIVALVYNVLKTFMEMNGKL 446

  Fly   602 FDELTSSYKAERQKEKKRERDREELWKKLHELESNRSSGRTAGGSATTSNSAASAASTSLQPPSS 666
            ||||||:||.||.:||:||:||:..|||:..||.|    ..|.|...|         .||.|..
Worm   447 FDELTSTYKGERLREKQREKDRDAFWKKMEALELN----PPAEGKEVT---------PSLFPEK- 497

  Fly   667 AGLNSHQQQSNSGSSGSLSSGGAGGDNNPA-----------TTNAK 701
              |..:.::.....:....:...|||.:|:           ||.||
Worm   498 --LTDYLKKDGPNMTPLPVATAGGGDKSPSVVKKSSTGSETTTPAK 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdb	NP_001368946.1	B56	235..633	CDD:396263	302/397 (76%)
pptr-1	NP_507133.4	B56	81..478	CDD:279883	302/396 (76%)
pptr-1	NP_507133.4	PLN00122	<384..478	CDD:215064	72/93 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165251
Domainoid	1	1.000	629	1.000	Domainoid score	I80
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55962
Inparanoid	1	1.050	654	1.000	Inparanoid score	I417
Isobase	1	0.950	-	0	Normalized mean entropy	S316
OMA	1	1.010	-	-		QHG54502
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	1	1.000	-	-		oto19303
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	1	1.100	-	-	LDO	PTHR10257
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750