Protein Alignment Klp98A and KIP1

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_009490.1
• Gene: KIP1 / 852216
• SGDID: S000000159
• Length: 1111
• Species: Saccharomyces cerevisiae
• Alignment Length: 1206
• Identity: 290/1206 - (24%)
• Similarity: 485/1206 - (40%)
• Gaps: 325/1206 - (26%)

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAE 66
            |::.|.||.|..|.|||:..:.:::.       .|.|:.:.| .....:|..::.....:.||..
Yeast    51 SNIHVYVRCRSRNKREIEEKSSVVIS-------TLGPQGKEI-ILSNGSHQSYSSSKKTYQFDQV 107

  Fly    67 DPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPN---------------N 116
            ....:.||.|::....:.:.....|||..:|||||||:|||:||.|..|               :
Yeast   108 FGAESDQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEH 172

  Fly   117 PGLIPRICEELFARM-RVGQESGTGYRTHASYLEIYNERVKDLL--------AAQSTGHGLRV-- 170
            .|:|||:..:||..: .:.:|    |....|:||:|||.:||||        |.......:|:
Yeast   173 AGIIPRVLVDLFKELSSLNKE----YSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFD 233

  Fly   171 REHRSLGPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTIT--------- 226
            ..:.:....|:.:.:..::...|....:.:|:.:|..|:|..||.|||||.:||||
Yeast   234 NNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNIVEQDSK 298

  Fly   227 -------FVQAVFMNDMPSETVSKIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISA 284
                   ||:           :.|::||||||||..|.:||..:|.:|...|||||:|||.||:|
Yeast   299 DHGQNKNFVK-----------IGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINA 352

  Fly   285 LAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYS 349
            |.:.:.                      :||||:|.||.||:|||||.:||.:||.:|||..:..
Yeast   353 LVDHSN----------------------HIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISME 395

  Fly   350 ETLSTLRYANRAKNIINKPTVNE----DTNVKLIRELREEINKLKSMLAGD-----IHSLQPSLK 405
            ||.|||.||.|||:|.|.|.||:    ||   .:::..:||.||::.|...     |...|..|
Yeast   396 ETASTLEYATRAKSIKNTPQVNQSLSKDT---CLKDYIQEIEKLRNDLKNSRNKQGIFITQDQL- 456

  Fly   406 VLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTTGV 470
               ||.:..:   :|.:|...|....:..:::.|...|.:..:..:|.||...||.|..:.....
Yeast   457 ---DLYESNS---ILIDEQNLKIHNLREQIKKFKENYLNQLDINNLLQSEKEKLIAIIQNFNVDF 515

  Fly   471 T-LYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHPWPL----AQCWVNAHL 530
            : .||                 :|:      :..|.::.|...|:....:.|    .|...|.::
Yeast   516 SNFYS-----------------EIQ------KIHHTNLELMNEVIQQRDFSLENSQKQYNTNQNM 557

  Fly   531 -IDEPKQISQGDIILLGRTNIFRFNNP-AEAAK-LRKDLSR------SQLDMSRLSLIT------ 580
             :...:|:.|....|.|..|  .:|:. :|..| :.::|:|      ::.|.:..||:.
Yeast   558 QLKISQQVLQTLNTLQGSLN--NYNSKCSEVIKGVTEELTRNVNTHKAKHDSTLKSLLNITTNLL 620

  Fly   581 SSKENLLTCSIYS-----DEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTI-ENALKQL 639
            .::.|.|..||.:     ..|..|.|::...:.|........:  ||::.:..||:| .:.|..:
Yeast   621 MNQMNELVRSISTSLEIFQSDSTSHYRKDLNEIYQSHQQFLKN--LQNDIKSCLDSIGSSILTSI 683

  Fly   640 NVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARK---DMLLWEKNNEKVQID 701
            |    ::.....|.:..:.   :.:|.::....:|:  :||:|..:|   |::     ||
Yeast   684 N----EISQNCTTNLNSMN---VLIENQQSGSSKLI--KEQDLEIKKLKNDLI-----NE----- 729

  Fly   702 IVCRQIS-AFQTQLDSKKRDFSEYVAKELQELQD----C--------GKLD-EMGMKIEEGTPLN 752
               |:|| .|..||...||.|.::|::...|..|    |        .||| ::..|........
Yeast   730 ---RRISNQFNQQLAEMKRYFQDHVSRTRSEFHDELNKCIDNLKDKQSKLDQDIWQKTASIFNET 791

  Fly   753 DELLLQV-SDSLDLFA--AQFIKDTVRRNNEE----------------------------IRKLD 786
            |.::.:: |||:...|  |:....||.:|||.                            :.|:.
Yeast   792 DIVVNKIHSDSIASLAHNAENTLKTVSQNNESFTNDLISLSRGMNMDISSKLRSLPINEFLNKIS 856

  Fly   787 EQIAEK----------------ERILNASTTKIAKVDETML----EIQAQLERLRLERAESEAES 831
            :.|.|.                ::..|...:.||..:|.::    |||:|:|.:
Yeast   857 QTICETCGDDNTIASNPVLTSIKKFQNIICSDIALTNEKIMSLIDEIQSQIETI----------- 910

  Fly   832 QAMRAKKQNMKLQLGNKSMSTSTSTNEAD------DVSKSD---TYETCD-------------TF 874
                :.:.|:.|...|::.::..:....|      .:||:.   ..|.|:             |.
Yeast   911 ----SNENNINLIAINENFNSLCNFILTDYDENIMQISKTQDEVLSEHCEKLQSLKILGMDIFTA 971

  Fly   875 HTAQSNLSLVSSPTITEGQQSPLSNCSCDAE--DEAEDTRKDDLSGSSEETSRTCTAGPSSGSGS 937
            |:.:..|...:.|..:..:..||.:.....:  .:||:..|||.|     .||||....|:...
Yeast   972 HSIEKPLHEHTRPEASVIKALPLLDYPKQFQIYRDAENKSKDDTS-----NSRTCIPNLSTNEN- 1030

  Fly   938 GSVGIGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNYK-QAVRTSDEDTGSCSSCEL 1001
                          .|.||..........|.....:|....:|:.| ...:|.....|:
Yeast  1031 --------------FPLSQFSPKTPVPVPDQPLPKVLIPKSINSAKSNRSKTLPNTEGT------ 1075

  Fly  1002 GRHSDVARPYCPLHSLRRKIAAQKALIMKNLETDLN 1037
            ||.|.        ::|:|:...:.  |:|..||:.|
Yeast  1076 GRESQ--------NNLKRRFTTEP--ILKGEETENN 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	134/410 (33%)
		Kinesin_assoc	370..478	CDD:465047	27/117 (23%)
		FHA_KIF16	449..556	CDD:438760	21/112 (19%)
		SMC_N	624..>864	CDD:481474	59/314 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
KIP1	NP_009490.1	KISc_BimC_Eg5	50..419	CDD:276815	136/412 (33%)
		235kDa-fam	<423..>948	CDD:130673	116/598 (19%)
		AAA_13	<562..>741	CDD:463796	43/204 (21%)