DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and POK2

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_188535.4	Gene:	POK2 / 821439	AraportID:	AT3G19050	Length:	2771	Species:	Arabidopsis thaliana

Alignment Length:	1449	Identity:	371/1449 - (25%)
Similarity:	582/1449 - (40%)	Gaps:	386/1449 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPR-LQSIRDAGRDNHHDFTFDYSYWSFDAE 66
            ::::.:||||.||.|..:         |...|.||.. .|.:...|..... |.||
plant   193 NVQILIRVRPLNSMERSI---------NGYNRCLKQESSQCVAWIGPPETR-FQFD--------- 238

  Fly    67 DPHFA----TQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG---------TPNNPG 118
              |.|    .||.::...|..:|:....|||:|:|||||||||||:||:|         :||. |
plant   239 --HVACETIDQETLFRVAGLPMVENCLSGYNSCIFAYGQTGSGKTYTMLGEVGDLEFKPSPNR-G 300

  Fly   119 LIPRICEELFARMRVGQESGTG----YRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPY 179
            ::|||.|.||||::..:||...    |....|:||||||::.|||...||  .|::||....|.|
plant   301 MMPRIFEFLFARIQAEEESRRDERLKYNCKCSFLEIYNEQITDLLEPSST--NLQLREDIKSGVY 363

  Fly   180 VENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKI 244
            ||||::..|....:|...|.:|:..|...:||||..|||||::||.........:...:...:::
plant   364 VENLTECEVQSVQDILGLITQGSLNRRVGATNMNRESSRSHSVFTCVIESRWEKDSTANMRFARL 428

  Fly   245 HLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASK 309
            :|||||||||...:||.|.||||.|.|||||.|||.||..|.:...|
plant   429 NLVDLAGSERQKTSGAEGDRLKEAASINKSLSTLGHVIMVLVDVANG------------------ 475

  Fly   310 RVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDT 374
            :..:||||||.||:||:|||||||||::||..||:....:|||:||::|.|||.|.|...||||:
plant   476 KPRHIPYRDSRLTFLLQDSLGGNSKTMIIANASPSVSCAAETLNTLKFAQRAKLIQNNAVVNEDS 540

  Fly   375 NV------KLIRELREEINKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQS 433
            |.      :.||.|:||::.||........|...:....|:.| .::...|:.|...::   |.:
plant   541 NEDVLELRRQIRLLKEELSLLKRQNISRALSFGSATANFAESQ-VDSPSSVMHETGQQQ---AGN 601

  Fly   434 IL------------QEQKSL------GLRKSGVGVV----LDSEMPHLIGI--HNDVTTGVTLYS 474
            :|            ::.|||      .||:..|...    |::|:.||..:  ..:..|..|...
plant   602 LLVYESGGCVRMSRKQLKSLEITLAGSLRREHVADASIKKLEAEIEHLNRLVRQREEDTRSTKMM 666

  Fly   475 LKEGETRIGSEDADVAQDIE-LAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWV------------ 526
            |:..|.:|        |.:| |.|:.|.|.  |..|:...|......|.|..:
plant   667 LRFREDKI--------QRLESLLGNHISAD--SFLLEENNVLSEEIQLLQAKIDKNPELTRFALE 721

  Fly   527 NAHLIDEPKQI----SQGD-IILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSKENL 586
            |..|:|:.::.    .:|: .||||           |.:.||..|.:. ||           ||
plant   722 NIRLLDQLRRFQEFYEEGEREILLG-----------EVSNLRNQLFQF-LD-----------EN- 762

  Fly   587 LTCSIYSD-----EDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLNVERVQM 646
                  ||     :||..|.....        ||:::..||:|.:|....:|..
plant   763 ------SDWQKHVDDGIEPQGASR--------MSKENCSLQEELKKTCYELEKC----------- 802

  Fly   647 HDQYKTKVRKLTEELIRLEQEEMDGLQLL-----NCR--EQELIARKDMLLWEKNNEKVQIDIVC 704
                ::.:....||..:|.: |::.||.:     .|.  |...:.::..||..:|.|..: .:.|
plant   803 ----RSNLGSCLEENAKLSR-EINDLQAMVSDIRACTPDEHSSVNKQKALLGTQNFEPHE-TLAC 861

  Fly   705 RQIS----AFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLL-------- 757
            .|.:    ..:.|||   .|..:.:..|.:.|:...:...:.:|.:... |.|:|||
plant   862 EQANYVEEIIKLQLD---LDVQKIILDEERTLRGDTEAQAVRLKFDIEV-LKDQLLLISKQQKNV 922

  Fly   758 --QVSDSLDLFAAQ------FIKDTVRRNNEEIRKLDEQIAE--KERILNASTTKIAKVDETM-- 810
              ::.::....||.      .|::.|     |:|::.|...|  |::.|:....|..:.||..
plant   923 YSELGETKSAVAALESQNIILIQEAV-----ELRRIKENYFELLKKQELDIPAMKSKQCDEFKDN 982

  Fly   811 ----LEIQAQLERLRLERAESEAESQAMRAKKQNM--KLQLGNKSMSTSTSTNEADDVSKSDTYE 869
                .||..:.:::         ::...:||:.||  |..:.:|    :....|.|:|.|.....
plant   983 PAEDSEIDTKFKKM---------QASLEKAKRLNMLYKSDIASK----ACGDEEMDEVCKQAEAA 1034

  Fly   870 TCDTFHTAQSNLSLV--------SSPTITEGQQSPLSNCSCDAEDEAEDTRKDD------LSGSS 920
            |.:.....|:.|.::        |...:||.|...|.....:.:|:..||..|:      |.|..
plant  1035 TAEVIVCLQNELEVLQKEVNDFQSKENVTEKQVEILETQMEELQDKLRDTTMDNEQLQEQLRGKD 1099

  Fly   921 EETSRTCTAGPSSGSGSGSVGIGGS-GSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNYKQ 984
            .|............|....:.:.|: |...:|..:...    ||...|.|.....|.|.|
plant  1100 MELLIISNEMELLTSELEEILLNGNEGLTDACYQADLI----SGSLPDKRIWISEQVGGL----- 1155

  Fly   985 AVRTSD------EDTGSCSSCELGRHSDVARPYCPLHSLRRKIAAQKALIM--------KNLETD 1035
             :||..      ||..||.       .|..:..|.:.|:.:.:.. .|::|        :..|||
plant  1156 -IRTLSERELMIEDLESCL-------EDANKKRCDIESMLKSLKG-AAIVMNEAHQREFEEKETD 1211

  Fly  1036 --LNKAQL---DEHIADLQD---------------------LQRRYIQMEQ-------------- 1060
              |.|:||   .|.|..||:                     :..||.::.:
plant  1212 VLLLKSQLCTKTETILRLQEKLKMAERLIYEASDCATASLIIVNRYSEVTESHTFELKQKDFQVA 1276

  Fly  1061 -------EMLQSVQDLEAHAQCCADERSGMERQYELASSIMRS----SVMSPTSMEESTSQIY-S 1113
                   .:.|.||||||   .|.:.||.:..:.:.||::.:.    ...|.::|:|..|::. .
plant  1277 ESTGTILSLKQQVQDLEA---TCKEFRSKLLEEEKNASAMEQKLEEIEETSISAMKEKLSELKGG 1338

  Fly  1114 PSMTRSCPSM----REFPEGEHFITIPSFVMRG---------------AGKQTHYE---YEVRIA 1156
            .|..|||.:|    .::.|.|:.::.|:....|               .....|.|   ...:::
plant  1339 VSDLRSCITMCQEHDKYTEAENSLSSPAHCSEGQEPGRNVVVSSCIEKTPNNNHTESMRLSSKVS 1403

  Fly  1157 LPDGKLNILRR------YSRFRELHLCMKHCYGAKISALPFPRREL---------------FASN 1200
            ...||:.||.:      .:..:|:.:.|.:..|.|.......:|.|               ..||
plant  1404 SERGKVIILLKQEMESALASLKEVQVEMANLKGEKEELKASEKRSLSNLNDLAAQICNLNTVMSN 1468

  Fly  1201 SEPVAKHRRRLLELYLRRL 1219
            .|...:|:..:.:..|:.|
plant  1469 MEEQYEHKMEVTDHKLKTL 1487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	154/385 (40%)
		KISc	3..371	CDD:214526	154/385 (40%)
		Kinesin_assoc	370..478	CDD:292801	32/137 (23%)
		FHA	456..555	CDD:238017	26/118 (22%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	20/128 (16%)
POK2	NP_188535.4	Motor_domain	192..540	CDD:277568	157/388 (40%)
		KISc	193..537	CDD:214526	154/385 (40%)
		Kinesin-relat_1	670..755	CDD:289481	24/105 (23%)
		SMC_prok_B	<877..1606	CDD:274008	127/651 (20%)
		Smc	1410..2238	CDD:224117	14/78 (18%)
		KASH_CCD	2086..2284	CDD:291334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	252	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910