DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and POK1

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001326049.1	Gene:	POK1 / 820999	AraportID:	AT3G17360	Length:	2075	Species:	Arabidopsis thaliana

Alignment Length:	1462	Identity:	361/1462 - (24%)
Similarity:	599/1462 - (40%)	Gaps:	415/1462 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLKVAVRVRPFNSRE-IDMDAQLIMEMENKKTR--LLKPRLQSIRDAGRDNHHDFTFDYSYWSFD 64
            :::|.:|:||..:.| .:......::.|:.:|.  |..|..:            ||||
plant   168 NVQVLIRLRPLGTMERANQGYGKCLKQESPQTLVWLGHPEAR------------FTFD------- 213

  Fly    65 AEDPHFA----TQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNP-------- 117
                |.|    :||:::...|..:|:....|||:|||||||||||||:||||..:..
plant   214 ----HVASETISQEKLFRVAGLPMVENCLSGYNSCVFAYGQTGSGKTYTMMGEISEAEGSLGEDC 274

  Fly   118 GLIPRICEELFARMRVGQE----SGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGP 178
            |:..||.|.||:|:::.:|    ....:....|:||||||::.|||...||  .|::||....|.
plant   275 GVTARIFEYLFSRIKMEEEERRDENLKFSCKCSFLEIYNEQITDLLEPSST--NLQLREDLGKGV 337

  Fly   179 YVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMND-MPSETVS 242
            |||||.:|.|....::.:.:.:|...|..|:|.||..|||||::||.| :::::..| :.....:
plant   338 YVENLVEHNVRTVSDVLKLLLQGATNRKIAATRMNSESSRSHSVFTCT-IESLWEKDSLTRSRFA 401

  Fly   243 KIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGA 307
            :::|||||||||..::||.|.||||.|:|||||.|||.||.:|.:...|.|.
plant   402 RLNLVDLAGSERQKSSGAEGDRLKEAANINKSLSTLGLVIMSLVDLAHGKHR------------- 453

  Fly   308 SKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNE 372
                 ::|||||.||:||:|||||||||::||.:||:.|:.:||||||::|.|||.|.|...|||
plant   454 -----HVPYRDSRLTFLLQDSLGGNSKTMIIANVSPSLCSTNETLSTLKFAQRAKLIQNNAKVNE 513

  Fly   373 DTNVKLIRELREEINKLK-------------SMLAGDIHSLQPS-----LKVLADLQ--KKEAQE 417
            |.:.. :..|::||.|||             ..|:..|.||:.|     .||..:.:  |...|.
plant   514 DASGD-VTALQQEIRKLKVQLTSLLKNHDSCGALSDCISSLEESRYSGTCKVAGETRQDKCHCQV 577

  Fly   418 KVLTEEW---TEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTTGV----TLYSL 475
            |.:.:..   ..:.|:|:|.||:.              ::|:..:..:..|:....    .:.:|
plant   578 KNMNDNMIGALRREKIAESALQKS--------------EAEIERIDCLVRDMEEDAKRIKIMLNL 628

  Fly   476 KEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQG 540
            :|                |..|:   .:.|:   .|.::|      .:|     ||:|.|.: :|
plant   629 RE----------------EKVGE---MEFCT---SGSLMT------KEC-----LIEENKTL-KG 659

  Fly   541 DIILLGRTNIFRFNNP------AEAAKLRKDLSRSQLDMSR------LSLITSSKENLLTCSIYS 593
            :|.|| |.:|.:  ||      .|..|||:.|.|.|.....      |:.:|..::.||......
plant   660 EIKLL-RDSIDK--NPELTRSALENTKLREQLQRYQKFYEHGEREALLAEVTGLRDQLLDVLEAK 721

  Fly   594 DEDGASPYKRPERQYYPQRPMSRDDPELQDENRKI---LDTIENAL-KQLNVERV---------- 644
            ||..:       :....:..|.::..:.::.|..:   ||.|:..| :.||.:::
plant   722 DESFS-------KHVMKENEMEKEFEDCRNMNSSLIRELDEIQAGLGRYLNFDQIQSNVVASSTR 779

  Fly   645 ---QMHDQYK-------TKVRKLTEE-------------LIRLEQ---------------EEMDG 671
               |::..:|       ..:.::.||             |::.::               ::::.
plant   780 GAEQVNQAHKHLMAETMPTISEIQEEVAISHSKNYDRGALVKTDEGIDRSILQFKLGKLMKDLEE 844

  Fly   672 LQLLNCREQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCG 736
            .:.|||:.::  ..|..|     :::..|::|..|:   :|:           .|:.:.|||
plant   845 ARTLNCKYEK--DHKSQL-----SQQEDIEVVREQV---ETE-----------TARTILELQ--- 885

  Fly   737 KLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQ------------I 789
                     ||...|..|...::.:..:  ..|.||||:.....|||.|::.            :
plant   886 ---------EEVIALQSEFQRRICNLTE--ENQSIKDTITARESEIRALNQDWEKATLELTNFIV 939

  Fly   790 AEKERILNAST--------------------TKIA----KVDETMLEIQAQLERLRLERAESEAE 830
            |..:.|.||||                    .|.|    |.:||:|.:|..||..|:..||
plant   940 AGSKSIKNASTQIESIICSFPQVNAWIGDYVEKAAKNCIKKEETILLLQKSLEDARILVAE---- 1000

  Fly   831 SQAMRAKKQNMK--------LQLGNKSMSTSTSTNEADDVSK-SDTYETCDTFHTAQSNLSLVSS 886
               |..|..::|        .|||..:.:|..:.|..:||.: ||..:|.::...| :..|::.:
plant  1001 ---MNLKLNSLKGATIALNEFQLGGNAATTEEAFNLNNDVDRMSDEVDTLESNFKA-NQYSILKT 1061

  Fly   887 PTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPSC 951
            ....|...: ::....|:.|:.:...|.......|..:.:..:...|..|:..:.:...|.....
plant  1062 ERHAEAALA-VTKWLSDSRDQHQMMEKVQDQSVKEFGTLSSISASLSAEGNADISLSRDGHLSDA 1125

  Fly   952 T-PSSQAIMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDED----------------TGSCSS- 998
            | |....:.:.|.   |..|.....:..||...|.|.:|:.|                .||..|
plant  1126 TYPKGDELSTSSS---DFSNCRWQHDCALNVKCQGVSSSESDAQESNNKITSAALIAKNGSAHSV 1187

  Fly   999 -CELGRHSDVARPY------------C--PLHS-----LRRKIAAQKALIMKNLETDLNKAQLDE 1043
             |..||.| |.:|.            |  ||.|     |.:::...:....:..|.:....:.|.
plant  1188 YCGEGRQS-VEKPLTIMMGREETEYKCSKPLSSGVYMGLMQRMDPVRTFFDRFEEVNATMKEADL 1251

  Fly  1044 HIADLQDLQRR--------------YIQMEQEMLQSVQDLEAHAQCCADERSGMERQYELASSIM 1094
            .|.:|.....:              .|..|:.::..::.:::....|.:|:..:..|.....:.|
plant  1252 TICELVKANEKSNSVTEMWLQTHEELISKEKNLMDDLEQVKSILSACEEEKQVLLNQTHTTLADM 1316

  Fly  1095 RSSVM--------SPTSMEESTSQIYSPS----------MTRSCPSMR----EFPEGEHFITIPS 1137
            .:||.        ....:||:...::|.:          ::.|.||:.    ||.|.|
plant  1317 ENSVSLLEEYFQEMKRGVEETVEALFSHARLAGKELLQLISNSRPSLEQIASEFMERE------- 1374

  Fly  1138 FVMRGAGKQTHYEYEVRIALPDGKL--NILRRYSRFRELHLCMKHC-YGAKISALPF-------- 1191
            |.|       :..|:..|    |||  .||.:..:....:|..:.. ...||:|:.:
plant  1375 FTM-------YATYQCHI----GKLIDQILDQRKQVITPNLSGQETNQSVKINAIGYNAEDEVTK 1428

  Fly  1192 --PRRELFA--SNSEPVAKHRRRLLE-LYLRR 1218
              .|.|:..  .|.|.|..|...|.| |||::
plant  1429 KQSREEIVTGLENDEVVQSHESLLYENLYLKK 1460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	150/387 (39%)
		KISc	3..371	CDD:214526	150/387 (39%)
		Kinesin_assoc	370..478	CDD:292801	28/134 (21%)
		FHA	456..555	CDD:238017	19/102 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	24/104 (23%)
POK1	NP_001326049.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	252	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I884
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.960