DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and kif1c

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_031755447.1	Gene:	kif1c / 779557	XenbaseID:	XB-GENE-997155	Length:	1105	Species:	Xenopus tropicalis

Alignment Length:	946	Identity:	334/946 - (35%)
Similarity:	481/946 - (50%)	Gaps:	235/946 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSF-DA 65
            :|:||||||||||||||..||:.:::|:...|.:..|:      ..:|:..:|||||||||. .|
Frog     4 ASVKVAVRVRPFNSREIAHDAKCVIQMQGNTTCISNPK------QPKDSAKNFTFDYSYWSHTTA 62

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNP--GLIPRICEELF 128
            |||:||:|.|||.|:|.:::..|:||||.|:||||||||||::||||.|.:.  |:||::||:||
Frog    63 EDPNFASQCQVYKDIGEEMLLHAFEGYNVCIFAYGQTGSGKSYTMMGKPESEQHGIIPQLCEDLF 127

  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193
            ||:...:..........||:|||.|||:|||..:|.|: ||||||..:|||||:||:.||:.:.:
Frog   128 ARVSANRSPDLSCSVEVSYMEIYCERVRDLLNPKSKGN-LRVREHPIMGPYVEDLSKLAVTSYHD 191

  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVF--MNDMPSETVSKIHLVDLAGSERAN 256
            |.:.:..||..||.|:||||:|||||||:|||.|.|...  |.::.:|.||||.||||||||||:
Frog   192 IADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQKRHDEMTNLDTEKVSKISLVDLAGSERAD 256

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            :|||.|.||||||:|||||.|||.|||||||.                ....|:..:||||||.|
Frog   257 STGAKGTRLKEGANINKSLTTLGKVISALAEM----------------QNKKKKSDFIPYRDSAL 305

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            |||||::|||||:|.|||||||||.||.|||||||||:|||.|.....:|||.|.:|||||:||:
Frog   306 TWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRAKQIKCNAVINEDPNARLIRELKEEV 370

  Fly   387 NKLKSML-------------AGDIHSLQP------------SLKVL------------------A 408
            .:|:.:|             |...|...|            ||..|                  |
Frog   371 ARLRQLLYSQGLEDIVIDDSASAPHPPSPAAAPVSPPPLPGSLAPLASPTQNGQSEPFPEGEDAA 435

  Fly   409 DLQKKEAQEKV---------LTEEWTEKWKVAQSILQEQKSL------GLRKSG--VGVVLDSEM 456
            ::..:||.|::         |.|.|.||.:..:::..|:::|      .:|:.|  |||....::
Frog   436 EICTEEAMERLQETEKIIAELNETWEEKLRKTEALRTEREALLAEMGVAVREDGGTVGVFSPKKI 500

  Fly   457 PHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGG-----VVT 515
            |||:.::.| :.:...||.:|||.||:|    .|..||:|:|..|:.|||.......     :||
Frog   501 PHLVNLNEDPLMSECLLYHIKEGITRVG----QVEVDIKLSGQFIKEQHCLFHCDTNPSGEVIVT 561

  Fly   516 LHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRS----------- 569
            |.|...|:.:||..|:.:...:..|..|::|:.::||||:| |.|:|.::.|.:
Frog   562 LEPCEGAETYVNGKLVTQALVLKSGTRIVMGKNHVFRFNHP-EQARLERERSSAAIENPSEPVDW 625

  Fly   570 ---------------QLDM-SRLSLI-----TSSKENLLTCS---IYSDEDG------------- 597
                           :|:| .||..:     ...:|..||..   :|:|.|.
Frog   626 NFAQKELLEKQGIDIKLEMEKRLQDLEYQYKKEKEEADLTLEQQRLYADSDSGDDSDKRSCEESW 690

  Fly   598 -------------------------ASPYKR-PERQY-YPQRPMSRDDPELQDENRKILDTIENA 635
                                     :|..|| |.|.| .|||.....||..    ..:.|....|
Frog   691 RLISSLREKVPAGRVQSIVRRCGLPSSGKKREPIRVYQIPQRRRLGKDPRW----LTLADLKMQA 751

  Fly   636 LKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQI 700
            :|::..| |.::|             .:..::|::.:.::..:|
Frog   752 VKEICYE-VALND-------------FKHSRQEIEAMSVIKMKE--------------------- 781

  Fly   701 DIVCRQISAFQTQLDSKKRDFSE-----YVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVS 760
              :||...         |||.:|     .||:::.:....|: ::.|.|...|.   .:|...:.
Frog   782 --LCRTYG---------KRDINEKELWKAVARDVWDTVGVGE-EDAGTKSVSGV---QDLKAHID 831

  Fly   761 DSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERIL 796
            ...|:.  |.:|......:||||.|.:::.:.||::
Frog   832 KLTDIL--QEVKLQNNMKDEEIRSLRDRMIKMERVM 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	206/373 (55%)
		KISc	3..371	CDD:214526	206/372 (55%)
		Kinesin_assoc	370..478	CDD:292801	42/168 (25%)
		FHA	456..555	CDD:238017	35/104 (34%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
kif1c	XP_031755447.1	KISc_KIF1A_KIF1B	4..355	CDD:276816	206/373 (55%)
		Kinesin_assoc	352..524	CDD:406567	43/171 (25%)
		FHA	501..601	CDD:238017	35/103 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010