DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and Stard9

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_017447698.1	Gene:	Stard9 / 691920	RGDID:	1593360	Length:	4604	Species:	Rattus norvegicus

Alignment Length:	1300	Identity:	430/1300 - (33%)
Similarity:	622/1300 - (47%)	Gaps:	248/1300 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSLKVAVRVRPFNSREIDMDAQLIMEMENK--KTRLLK--PRLQSIRDAGRDNHHDFTFDYSYW 61
            |::::|||||||.:.||.....::|:|:::|  |.|.:|  .||:|..|. |:....|.|||.||
  Rat     1 MANVQVAVRVRPLSKRETKEGGRIIVEVDDKVAKVRNVKVNSRLESFGDT-REKVVAFGFDYCYW 64

  Fly    62 SFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEE 126
            |.:.||||:|:||.|:.|||.:|:..|.:|||.|:|||||||||||:||:|||.:.||.|||||.
  Rat    65 SVNPEDPHYASQEVVFRDLGTEVLSGASKGYNICLFAYGQTGSGKTYTMLGTPASVGLTPRICEG 129

  Fly   127 LFARMRVGQESGTGYRTHASYLEIYNERVKDLL--AAQSTGHGLRVREHRSLGPYVENLSQHAVS 189
            ||.|...............|:||||||||:|||  :.|:..:.||||||..:||||:.||||||:
  Rat   130 LFIREDDCASMPYSRSIKVSFLEIYNERVRDLLKQSNQNKSYTLRVREHPEMGPYVQGLSQHAVT 194

  Fly   190 DFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDLAGSER 254
            .:.::.:.:..|.|.|.||:|::::.||||||||||...||...|::||||.|||:|||||||||
  Rat   195 SYQQVLQLLEEGIANRITAATHVHEASSRSHAIFTIHCTQATLQNNLPSETASKINLVDLAGSER 259

  Fly   255 ANATGATGQRLKEGAHINKSLVTLGSVISALAEQ--------------TGGGHNSSSSALATTPN 305
            |:.:... .|:.|||:|||||||||.|||.||:.              :.||.:...|..:.|.:
  Rat   260 ADPSYCK-DRITEGANINKSLVTLGIVISTLAQNSQVFSSCQSLSSAASSGGDSGIPSTTSGTSS 323

  Fly   306 GA--SKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKP 368
            |.  ::|..|||||||:||||||:||||||||||:|.:|||..:||||:||:|||:.||||||||
  Rat   324 GGGPARRQSYIPYRDSVLTWLLKESLGGNSKTIMVATVSPAHTSYSETMSTMRYASNAKNIINKP 388

  Fly   369 TVNEDTNVKLIRELREEINKLKSMLAG----DIHSLQPSL-KVLADLQ-KKEAQEKVLTEEWTEK 427
            .||||.||||||||||||.:||:||..    :..||...| :.|.:|. :.:.:...||:.||:|
  Rat   389 QVNEDANVKLIRELREEIERLKAMLLNFELRNFSSLNDDLDESLQELVFQNDLKIDTLTQHWTQK 453

  Fly   428 WKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDV-TTGVTLYSLKEGETRIGSEDADVAQ 491
            ....|: |.|...:|:.::...||:||.:|||:.:.:|| :||:.||.||||.||||..|:|..|
  Rat   454 PNNRQA-LMEHYGVGINRNRARVVIDSSLPHLMALEDDVLSTGIVLYHLKEGTTRIGRIDSDQEQ 517

  Fly   492 DIELAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNP 556
            ||.|.|..|...||:|....|||.|.|...|:|.||...:....:::||.:|.||:...||||:|
  Rat   518 DIVLQGQWIERDHCTITSTCGVVILRPSQGARCTVNGREVTASCRLTQGAVITLGKAQKFRFNHP 582

  Fly   557 AEAAKLRKDLSRSQLDMSRLSLITSSKENL-LTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPE 620
            ||||.||::    :|.:..:...:.|.|.| |...:.:...|..|..|.||:...:: ..:|...
  Rat   583 AEAAALRQE----RLKVGEVLGSSGSLEWLDLDGDVSASRLGLCPVLRKERRVLEEQ-SDKDQQP 642

  Fly   621 LQDENRKILDTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIAR 685
            |:  |.||....:...:|.:||                    .|:|:..:|
  Rat   643 LR--NGKISYRAQTEQQQCHVE--------------------ALKQQAKEG-------------- 671

  Fly   686 KDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKE------LQELQ---DCGKLDEM 741
                     ..:||     :::...||.::.|..|..:::.:|      |:|.|   |||:..|:
  Rat   672 ---------QSRVQ-----KELKLDQTHINRKITDNQQWLLREETWLSNLRETQQEGDCGEEKEL 722

  Fly   742 GMKIEEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKV 806
                 |.....|..|..|..:......|..|..|                :.|.|...|::....
  Rat   723 -----EAFVAPDAWLPTVPQTPPSPLVQSQKRVV----------------QPRCLRKHTSRATVW 766

  Fly   807 DETMLEIQAQLERLRLERAESEAESQAMRAKKQNMKLQL----GNKSMSTSTSTNEADDVS-KSD 866
            :....::..||||:..:|...||:   .|.::.|....:    .:|:.|.::|:|.....| :..
  Rat   767 NIRQKKVSFQLERIIKKRRLLEAQ---RRLEQLNALFWIQDNGTSKAPSWASSSNTTGSGSQRRS 828

  Fly   867 TYETCDT-------------FHTAQSNL--SLVSSPTITEGQQSPLSNCSCDAEDEAE--DTRKD 914
            .:.||.:             ..:|..|.  |.:|.|.....||.|....|.|...:|.  ..|..
  Rat   829 RWTTCSSLSLQRLCSQRLSQLRSAVMNWDPSAMSPPVPDLTQQMPEKTLSTDTVPQATACPPRTG 893

  Fly   915 DLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPSCTPSSQ-------------------AIMS 960
            .|..:|..:||.....|:.|:...|..|...|. .||..|||                   |...
  Rat   894 CLGRNSLHSSRWRKFSPARGASVSSQKIESFGK-QSCQMSSQGQSTKKQKPTDGSRIFTPAAQTK 957

  Fly   961 DSGVCLDSRNQAILQNGH-LNNYKQAVRTSDEDTGSCSSCELGRHSDV-------ARPYCPLHSL 1017
            ..|:......|.:.|... ...||....|:...|....|.::..|..|       ::|..|..:.
  Rat   958 AKGLVASVNTQTVWQKEESCATYKAPKETTSHPTYLSGSEQVAGHRKVVKTSLAESKPPPPSRAS 1022

  Fly  1018 R---RKIAAQKALIMKNLE--------------------TDLNKAQLD---EHIADLQD------ 1050
            :   |.:||:...|.|...                    || ::..:|   |...||.|
  Rat  1023 KKHQRVLAARARDIAKKFSRLSCGCPLKKQPSAEDPTSFTD-SRPIMDHVREEDKDLSDTESSYS 1086

  Fly  1051 ---LQRRYIQMEQEMLQSVQDLEAHAQCCADERSGMERQYELASSIMRSSVMSPTSMEESTSQIY 1112
               |...|.::.:|:|:..:               ::.:::|.         .|.:.|...|||.
  Rat  1087 VDSLSYIYAKVPKELLKPEE---------------LQGKWDLP---------DPDNSESGNSQIS 1127

  Fly  1113 SPSMTRSCPSMREFPEGEHFITIPSFVMRGAGKQTHYEYEVRIALPDGKLNILRRYSRFRELHLC 1177
            ..|:.           |:...::|.   ..||:.:..:|....|.|...:..|..||   :..||
  Rat  1128 EDSLA-----------GKGHQSLPE---NSAGEYSMKDYGHSRARPSASVRGLPMYS---DSSLC 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	203/390 (52%)
		KISc	3..371	CDD:214526	203/389 (52%)
		Kinesin_assoc	370..478	CDD:292801	49/114 (43%)
		FHA	456..555	CDD:238017	45/99 (45%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	10/46 (22%)
Stard9	XP_017447698.1	KISc_KIF1A_KIF1B	2..391	CDD:276816	203/390 (52%)
		KISc	3..391	CDD:214526	203/389 (52%)
		Kinesin_assoc	390..504	CDD:292801	49/114 (43%)
		FHA	481..581	CDD:238017	45/99 (45%)
		CBP4	<4150..4247	CDD:285235
		SRPBCC	4378..4552	CDD:301327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920