DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and Stard9

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_036018388.1	Gene:	Stard9 / 668880	MGIID:	3045258	Length:	4598	Species:	Mus musculus

Alignment Length:	1309	Identity:	421/1309 - (32%)
Similarity:	606/1309 - (46%)	Gaps:	306/1309 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHD---FTFDYSYWS 62
            |::::|||||||.:.||.....::|:|:::|..::...::.|..::..|....   |.|||.|||
Mouse     1 MANVQVAVRVRPLSKRETKEGGRIIVEVDDKVAKIRNVKVDSRPESFGDTREKVVAFGFDYCYWS 65

  Fly    63 FDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEEL 127
            .:.||||:|:||.|:.|||.:|:..|.:|||.|:|||||||||||:||:|||.:.||.|||||.|
Mouse    66 VNPEDPHYASQEVVFRDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPASVGLTPRICEGL 130

  Fly   128 FARMRVGQESGTGYRTHASYLEIYNERVKDLL--AAQSTGHGLRVREHRSLGPYVENLSQHAVSD 190
            |.|...............|:||||||||:|||  :.|:..:.||||||..:||||:.||||.|::
Mouse   131 FIREDDCASQPCSRSIKVSFLEIYNERVRDLLKQSNQNKSYTLRVREHPEMGPYVQGLSQHVVTN 195

  Fly   191 FDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDLAGSERA 255
            :.::.:.:..|.|.|.||:|::::.||||||||||...||:..|::||||.|||:||||||||||
Mouse   196 YQQVIQLLEAGIANRITAATHVHEASSRSHAIFTIHCTQAILQNNLPSETASKINLVDLAGSERA 260

  Fly   256 NATGATGQRLKEGAHINKSLVTLGSVISALAEQ--------------TGGGHNS--SSSALATTP 304
            :.:... .|:.|||:|||||||||.|||.||:.              :.||.:.  |:::.|::.
Mouse   261 DPSYCK-DRITEGANINKSLVTLGIVISTLAQNSQVFSSCQSLSSAASSGGDSGVPSTTSGASSG 324

  Fly   305 NGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPT 369
            .|.::|..|||||||:||||||:||||||||||:|.:|||..:||||:||:|||:.||||||||.
Mouse   325 GGPARRQSYIPYRDSVLTWLLKESLGGNSKTIMVATVSPAHTSYSETMSTMRYASNAKNIINKPR 389

  Fly   370 VNEDTNVKLIRELREEINKLKSMLAG----DIHSLQPSL-KVLADLQ-KKEAQEKVLTEEWTEKW 428
            ||||.||||||||||||.:||::|..    :..||...| :.|.:|. :.:.:...||:.||||.
Mouse   390 VNEDANVKLIRELREEIERLKAVLLNFELRNFSSLNDDLDESLQELVFQSDLKIDTLTQHWTEKR 454

  Fly   429 KVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDV-TTGVTLYSLKEGETRIGSEDADVAQD 492
            ...|: |.|...:.:.:....||:||.:|||:.:.:|| :|||.||.||||.|:||..|:|..||
Mouse   455 NDRQA-LMEHYGVDINRKRARVVIDSSLPHLMALEDDVLSTGVVLYHLKEGTTKIGRIDSDQEQD 518

  Fly   493 IELAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQ-------------GDIIL 544
            |.|.|..|...||:|....|||.|.|...|:|.||...:....:::|             |.:|.
Mouse   519 IVLQGQWIERDHCTITSTCGVVILRPTQGARCTVNGREVTASCRLTQGRDYGLNSGWCVTGAVIT 583

  Fly   545 LGRTNIFRFNNPAEAAKLRKDL-----------SRSQLDM------SRLSLITSSKENLLTCSIY 592
            ||:...||||:|||||.||...           |...||:      |||.|....::........
Mouse   584 LGKAQKFRFNHPAEAAVLRHQRLKVGEALGSSGSLEWLDLDGDVSASRLGLCPVLRKERRVLEEQ 648

  Fly   593 SDED------GASPYK-RPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLNVERVQMHDQY 650
            .|.|      ...||: :||:|......:.:...|.|          ....|:|.::...:..|.
Mouse   649 CDRDQQPSRHSEIPYRAQPEQQQCHVEALKQQAKEGQ----------SRVQKELELDHTHISQQI 703

  Fly   651 KTKVR-KLTEE--LIRLEQEEMDGLQLLNC-REQELIA----------------------RKDML 689
            |...: .||||  |..|.:.:.:|    || .|:||.|                      :|.::
Mouse   704 KDNQQWLLTEETWLASLRETQQEG----NCGEEKELEASVAPDAWLPTVPQTPPSPLVQSQKRVV 764

  Fly   690 -------------LWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQEL------QDC 735
                         :|....:||          :||.:...|||...| ..:.|::|      ||.
Mouse   765 QPQCSPRHTTRATVWNIRQKKV----------SFQLERIIKKRRLLE-AQRRLEQLSTFFWIQDD 818

  Fly   736 G------------------------------KLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQF 770
            |                              .|..:|.:                 .|....:.|
Mouse   819 GASRAPSWASSSNTSGPGSQRRSRWTTCSSLSLQRLGCR-----------------RLPQLHSDF 866

  Fly   771 IKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAESEAESQAMR 835
            :.......:..:.:|..|:.||....:....|..:           |.|.....:.....|.|.|
Mouse   867 MNWDPSAMSPPVPELTHQMPEKTLSTDCIPPKAGR-----------LGRNSFHSSRWRKFSPARR 920

  Fly   836 AKKQNMKLQLGNKSMST------------------STSTNEADDVSKSDTYETCDTF-HTAQSNL 881
            |..|...|.:.:||:|:                  ||...:|.|.|:        || ..||:..
Mouse   921 ASTQGTHLTVSHKSVSSQEIESLGKQPCQMSSQGQSTKKQKARDGSR--------TFIPAAQTRW 977

  Fly   882 SLVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSG 946
            :.|::.|   |.|.. ..|....:.:...::..||||..          |::|... .|....:.
Mouse   978 ASVNTKT---GWQKE-GTCGTYKDPKETTSQSTDLSGLE----------PAAGHRK-VVKTFQAE 1027

  Fly   947 SAPSCTPSSQAIMSDSGVCLDSRNQAILQ-------NGHLNNYKQAVRTSDEDTGSCSSCELGRH 1004
            |.||  |||:|......| |.:|.:.|::       .|.|.|..:|     .|.|:.:|     .
Mouse  1028 SKPS--PSSRASKKHQRV-LAARARDIVKTFSRLPHGGPLKNQPRA-----GDPGTPAS-----F 1079

  Fly  1005 SDVARPYCPLHSLRRKIAAQKALIMKNLETDLNKAQLDEHIADLQD---------LQRRYIQMEQ 1060
            :| :||.                          |..:.|...||.|         |...|.::.:
Mouse  1080 TD-SRPI--------------------------KDPVREEDRDLSDTESSYSVDSLSYIYAKVPK 1117

  Fly  1061 EMLQSVQDLEAHAQCCADERSGMERQYELASSIMRSSVMSP--TSMEESTSQIYS-----PSMTR 1118
            ::|:. :||:........|.|..:.     |.|...|:...  .|:.|::...||     .|..|
Mouse  1118 KLLKP-EDLQGKWNLPDSENSESDN-----SQISEDSLAGKGHKSLPENSRGEYSMKDHGHSRAR 1176

  Fly  1119 SCPSMREFP 1127
            :..|:|..|
Mouse  1177 TSASVRGLP 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	196/389 (50%)
		KISc	3..371	CDD:214526	196/388 (51%)
		Kinesin_assoc	370..478	CDD:292801	49/114 (43%)
		FHA	456..555	CDD:238017	45/112 (40%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Stard9	XP_036018388.1	KISc_KIF1A_KIF1B	2..391	CDD:276816	196/389 (50%)
		Kinesin_assoc	390..504	CDD:406567	49/114 (43%)
		FHA	481..594	CDD:238017	45/112 (40%)
		SRPBCC	4394..4598	CDD:417480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020