Protein Alignment Klp98A and kif21b

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_073772347.1
• Gene: kif21b / 570502
• ZFINID: ZDB-GENE-130530-537
• Length: 1669
• Species: Danio rerio
• Alignment Length: 1225
• Identity: 318/1225 - (25%)
• Similarity: 526/1225 - (42%)
• Gaps: 284/1225 - (23%)

  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67
            |:||::|:||..::|......:...:...:.::|         .|:|.  .||:|:   .||.:
Zfish     8 SVKVSLRIRPQMAKEKIEGCHICTSVTPGEPQVL---------LGKDK--AFTYDF---VFDLD- 57

  Fly    68 PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGT-------PNNPGLIPRICE 125
               |.|:|:||...:.:::..:|||||.||||||||||||:| |||       .:..|:|||...
Zfish    58 ---AHQQQIYSACVHKLIEGCFEGYNATVFAYGQTGSGKTYT-MGTGFDVSVSEDEQGIIPRAVH 118

  Fly   126 ELF---ARMRVGQESG----TGYRTHASYLEIYNERVKDLL------AAQSTGHGLRVREHRSLG 177
            :||   .:.|:..:|.    ..::..|.:||:|||.:.||.      .|:.....:::.|..|.|
Zfish   119 QLFQGIQKRRLEAQSADIPPPDFKVSAQFLELYNEEILDLFDSTRDPEARGRKSNIKIHEDGSGG 183

  Fly   178 PYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVF---------- 232
            .|...::...||..||:.:|:..|...||||||.||..||||||||||...|...
Zfish   184 IYTTGVTSRLVSSEDELLQCLKLGALSRTTASTQMNAQSSRSHAIFTIHLCQMRVCPQPQLVNGE 248

  Fly   233 --------MNDMPSETVS-KIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQ 288
                    |:....||:| |.|.||||||||...|||||:|.:||..||..|:.||:|||||.:|
Zfish   249 LNGVSDGSMSQSEYETLSAKFHFVDLAGSERLKRTGATGERAREGISINCGLLALGNVISALGDQ 313

  Fly   289 TGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLS 353
                               |||..::|||||.||.||:|||||||:|:|||.:||:|.::.|||:
Zfish   314 -------------------SKRAGHVPYRDSKLTRLLQDSLGGNSRTVMIACVSPSDRDFMETLN 359

  Fly   354 TLRYANRAKNIINKPTVNEDTNVKLIRELREEINKLKSMLAGDIHSLQPSLKVLADLQKKEAQEK 418
            ||:|||||:||.||..||:|...:.|..||.||.:|:                 .::.:.:|.::
Zfish   360 TLKYANRARNIKNKVIVNQDKTSQQISALRAEIARLQ-----------------MEIMEYKAGKR 407

  Fly   419 VLTEEWTEKWK---VAQSILQ-EQKSLGLRKSGVGVVLDSEMPHL-IGIHNDVTTGVTLYSLKEG 478
            |..:|.:|.:.   ...|:|| |..:|.:|...:...:|    || ..:...:|.||.|...|.|
Zfish   408 VACDEGSEGFSDLFQENSMLQRENDTLRMRVKAMQETID----HLNTRVTQLLTNGVNLLLTKTG 468

  Fly   479 ET--RIGSEDADVAQDI----------ELAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLI 531
            ||  .||:...:..::|          |...:.:|.....:..:....:.||        :|..|
Zfish   469 ETNEEIGNLIQNYIREIEELRSKLLESEAMNESLRRSLSRLSSRSVYPSSHP--------SAPSI 525

  Fly   532 DEPKQIS----QGDIILLGRTNIFRF---------NNPAEAAKLRKDLSRSQL------DMSRLS 577
            .....:|    ..|:|...:.::.|.         ..|.:...|:|   |::|      :.|...
Zfish   526 GSSPSVSMEAEMTDVIRQAKLDVERLKKKERNQRRKRPEKEKGLKK---RAKLHPEESGEKSENG 587

  Fly   578 LITSSKENLLTCSIYSD----EDGASPYKRPER------QYYPQRPMSRDDPELQDENRKILDTI 632
            |..:::|........||    |||..|.:..:.      :...:...:|::.|. |.:..::|:.
Zfish   588 LNRANEERRENGDGDSDNEPEEDGMYPLQEDDHGESGCDEEEEEEEETREEEEF-DSDESLVDSD 651

  Fly   633 ENALKQLNVER--VQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEK-N 694
            .:..:::|::.  ..:..:.:.|.|.:.|    ||..:...|.|.:..|::||     ||..| .
Zfish   652 SDTDEKVNLQADLADLTCEIEIKQRLIDE----LENSQRRLLTLKSQYEEKLI-----LLQNKIR 707

  Fly   695 NEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQV 759
            :.:::.|.|...:.:.:...:.|.........|.|:|:.
Zfish   708 DTQLERDRVLHNLMSMENYTEEKASKVKSEYEKRLKEMN-------------------------- 746

  Fly   760 SDSLDLFAAQFIKDTVR------RNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQA--- 815
            .|.|.|.|||  |:..|      |...|::||..::||.::...|...::.:..:....|.|
Zfish   747 RDLLKLQAAQ--KEHARLLKNQGRYERELKKLQSEVAEMKKAKVALMKQMKEEQQRRRMIDAKRN 809

  Fly   816 -QLERLRLERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQS 879
             ::.:|:.|:...|.:.:|:.::|:..:|.|..|:...:.....|..:|:...........:..|
Zfish   810 REIAQLKKEQRRQEYQIRALESQKRQQELVLRRKTQEVTALRRLAKPLSERAAGRVSRRLTSVDS 874

  Fly   880 NLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTA-------------GP 931
            ...|.:|.|.|...: |.|:.|..:.....:|:   |:|...||.....|             ||
Zfish   875 GAELSTSTTTTTSSE-PESSRSVSSIIRHWNTK---LNGYLGETDSHAPAANMASSRKKFQRKGP 935

  Fly   932 SSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDEDTGSC 996
            |||.         |.:|.....|.:..:.|          .::|...:.|.:
Zfish   936 SSGF---------SKTARQKWQSLERRIMD----------IVMQRMTITNVE------------- 968

  Fly   997 SSCELGRHSDVARPYCPLHSLRRKIAAQKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQMEQE 1061
                    :|:.|    |...|.:::.|:..:::..|..|:::..:|      |.:|    :.||
Zfish   969 --------ADMDR----LIKKREELSVQQEALLRKREKLLSESFREE------DEER----LLQE 1011

  Fly  1062 MLQSVQDLEAHAQCCADERSG-------MERQYELASSIMRSSVMSPTSMEESTS 1109
            |.:.::.|.|:....:|..|.       :|...:...|:..|.|:|..|:.|:.|
Zfish  1012 MNEEIEVLNANIDYISDSLSDCQATIVQIEETKDELDSVDTSVVISSCSLAEARS 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	160/406 (39%)
		Kinesin_assoc	370..478	CDD:465047	27/112 (24%)
		FHA_KIF16	449..556	CDD:438760	24/132 (18%)
		SMC_N	624..>864	CDD:481474	47/252 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
kif21b	XP_073772347.1	None