Protein Alignment Klp98A and KIF15

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_016862373.1
• Gene: KIF15 / 56992
• HGNCID: 17273
• Length: 1411
• Species: Homo sapiens
• Alignment Length: 1382
• Identity: 362/1382 - (26%)
• Similarity: 574/1382 - (41%)
• Gaps: 332/1382 - (24%)

  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67
            ::||.||:||...|....|.:     :|....:|..  .|:|.........||||
Human    26 AIKVFVRIRPPAERSGSADGE-----QNLCLSVLSS--TSLRLHSNPEPKTFTFD---------- 73

  Fly    68 PHFA----TQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG-------TPNNPGLIP 121
             |.|    |||.|::.:...:|:....|||..:||||||||||||||||       :.|..|:||
Human    74 -HVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIP 137

  Fly   122 RICEELFARM-RVGQESGTG--YRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENL 183
            |..|.||:.: |..:::|.|  :....|::|||||::.|||  .|...||.:|||...|.:|...
Human   138 RSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLL--DSASAGLYLREHIKKGVFVVGA 200

  Fly   184 SQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVD 248
            .:..|:...|..:.::.|...|..|||:||..||||||:||||.......|::.:...|.::|||
Human   201 VEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVNIRTSLLNLVD 265

  Fly   249 LAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLY 313
            ||||||...|.|.|.||||..:||:||..||.||:||.:               ..||..:.|.
Human   266 LAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVD---------------VGNGKQRHVC- 314

  Fly   314 IPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKL 378
              ||||.||:||:||||||:||.:||.:.|....:.||||||.:|.|||.|.||..|||||...
Human   315 --YRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGN- 376

  Fly   379 IRELREEINKLKSMLAGDIHSLQ--PSLKVLAD----------------LQKKEAQEKVLTEEWT 425
            :.:|:.|:.:||..|| ::.|.|  |...:..|                .:|.|.::|.|.|:.|
Human   377 VSQLQAEVKRLKEQLA-ELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKKSLIEKVT 440

  Fly   426 E-------KWKVAQS-----------ILQEQKSLGLRKSGVGVVLDSEMPHLIG-IHNDVTT--- 468
            :       |.|..||           |::.:|   |.|...|..|..|...|:. :.|::.|
Human   441 QLEDLTLKKEKFIQSNKMIVKFREDQIIRLEK---LHKESRGGFLPEEQDRLLSELRNEIQTLRE 502

  Fly   469 -----------GVTLYSLKEGETRI---------GSEDADVAQDIELAGDGIRAQHCSIFLKGGV 513
                       .:..:||:|...|:         ...||.....:|.|...|.....|...:.|.
Human   503 QIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGF 567

  Fly   514 VTLHPWPLAQ---CW------VNAHLI-------------DEPKQIS-------QGDIILLGRTN 549
            .     |.||   |.      :.|.|:             :|.|:::       :.::..|.:.|
Human   568 S-----PKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKAN 627

  Fly   550 IFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSD-----EDGASPYK---RPER 606
            : ...|..||.|..|....|||  :::...|...:|::.  ||:|     ..|..|.:   .|.:
Human   628 L-NLENLLEATKACKRQEVSQL--NKIHAETLKLKNVMW--IYNDLFNLENAGFFPIQIITTPTK 687

  Fly   607 QY-YPQRPMSRDDPE------LQDENRKILDT-----------IENALKQLNVERVQMHDQYKTK 653
            .| ...||:.:..||      |..:|..|||.           .|.|.:.::.|...:.:|....
Human   688 AYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSAL 752

  Fly   654 VRKLTEE---LIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKV--QIDIVCRQISAFQT- 712
            ..||.||   .::| |:.:|.|:..:.:.|||.: .:.:.|.|..|::  |::::.:|:...||
Human   753 QAKLDEEEHKNLKL-QQHVDKLEHHSTQMQELFS-SERIDWTKQQEELLSQLNVLEKQLQETQTK 815

  Fly   713 --------------------QLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIE---EGTPLNDE 754
                                :|.|.|.::|.:...:.:|.   .||.|..|.::   :...|.:|
Human   816 NDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEF---NKLSERHMHVQLQLDNLRLENE 877

  Fly   755 LLLQ----VSDSLDLF--AAQFIKDTVRRNNEEIRKLDEQI------------AEKERILNASTT 801
            .||:    :.||.|..  ..:|..|.:.||.:..:|.:|.:            |||||....|..
Human   878 KLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQ 942

  Fly   802 KIAKVDETMLEIQAQLERLRLERAESEAESQAMRAKKQNMK--LQLGNKSMSTSTSTNEADD--- 861
            .....:.:..||...||.:|.|:.:..|:.:...||.|.::  |....|.:|:...:.::|.
Human   943 FEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVV 1007

  Fly   862 -----------VSKSDTYETCDTFHTAQSNLSLVSSPTITEGQQSP--LSNCSCD---------- 903
                       .|..:..||.||......:::...:..:.:.::|.  :.....|
Human  1008 ADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRL 1072

  Fly   904 ---AEDEAEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGVC 965
               :||...|...:||:.::|:.:....|   |...||.:     .||.......:|::.:....
Human  1073 RILSEDIERDMLCEDLAHATEQLNMLTEA---SKKHSGLL-----QSAQEELTKKEALIQELQHK 1129

  Fly   966 LDSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDVARPYCPLH---SLRRKIAAQKAL 1027
            |:.:.:.:.|..:..|:|........|:.:         .|...|..|.|   .|.:.:..|:..
Human  1130 LNQKKEEVEQKKNEYNFKMRQLEHVMDSAA---------EDPQSPKTPPHFQTHLAKLLETQEQE 1185

  Fly  1028 I---------MKNLETDLNKAQLDEHI--ADLQDLQRRYIQMEQEMLQSVQDLEAH--AQCCADE 1079
            |         :::|.|.||:   |..:  |::..::.:..:||...|:|.|.:|.:  .|...|:
Human  1186 IEDGRASKTSLEHLVTKLNE---DREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDD 1247

  Fly  1080 RSGMERQYE-----------------------LA-SSIMRSSVMSPTSMEESTSQIYSPSMTRSC 1120
               ::||.|                       || |.|:...:.....:||..|.:|:..|  .|
Human  1248 ---IKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEM--EC 1307

  Fly  1121 PSMREFPEGEHFITIPS 1137
              :|...|.|...|:.|
Human  1308 --LRMTDEVERTQTLES 1322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	152/381 (40%)
		Kinesin_assoc	370..478	CDD:465047	37/158 (23%)
		FHA_KIF16	449..556	CDD:438760	27/159 (17%)
		SMC_N	624..>864	CDD:481474	68/313 (22%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	2/7 (29%)
KIF15	XP_016862373.1	KISc_KLP2_like	25..373	CDD:276824	155/384 (40%)
		SMC_N	<371..643	CDD:481474	59/282 (21%)
		SMC_prok_B	<579..1362	CDD:274008	160/781 (20%)