DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and kif1ab

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_009296795.1	Gene:	kif1ab / 566766	ZFINID:	ZDB-GENE-070912-480	Length:	1799	Species:	Danio rerio

Alignment Length:	1601	Identity:	437/1601 - (27%)
Similarity:	676/1601 - (42%)	Gaps:	501/1601 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDA- 65
            :|:||||||||||||||..|::.|::|....|.:|.|:...       .:..|.|||||||...
Zfish     4 ASVKVAVRVRPFNSREIGKDSKCIIQMSGNTTTILNPKQPK-------ENKSFNFDYSYWSHTTP 61

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNNPGLIPRICEELF 128
            ||.::|.|:|||.|:|.:::..|:||||.|:|||||||:||::||||  ..:..|:||.:||:||
Zfish    62 EDVNYACQKQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQEGIIPLLCEDLF 126

  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193
            .::....::...|....||:|||.|||:|||..::.|: ||||||..:|||||:||:.||:.:::
Zfish   127 TKINDNNDNNMSYSVEVSYMEIYCERVRDLLNPKNKGN-LRVREHPLMGPYVEDLSKLAVTSYND 190

  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDM--PSETVSKIHLVDLAGSERAN 256
            ||:.:..||..||.|:||||:|||||||:|.|.|.|....||.  .:|.||||.||||||||||:
Zfish   191 IQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKQHDNDSENTTEKVSKISLVDLAGSERAD 255

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRV-LYIPYRDSI 320
            :|||.|.||||||:|||||.|||.|||||||...          |...|...|:| .:||||||:
Zfish   256 STGAKGTRLKEGANINKSLTTLGKVISALAEMDS----------APNKNKKKKKVESFIPYRDSV 310

  Fly   321 LTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREE 385
            |||||:::|||||:|.|:|||||||.||.|||||||||:|||.|.....:|||.|.:|:|||:||
Zfish   311 LTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLVRELKEE 375

  Fly   386 INKLKSML----AGD-----------IHSLQ---------------------PSLKVLAD----- 409
            :.:||.:|    .||           |.|:|                     |||..|..
Zfish   376 VARLKDLLYAQGLGDIIENLSNYKANISSIQAVNQRGDFSTVTNAMTGMSPSPSLSALTSRVGSI 440

  Fly   410 ----------------LQKKEAQEKV---LTEEWTEKWKVAQSILQEQKSL------GLRKSG-- 447
                            :::.:..||:   |.|.|.||.:..::|..|:::|      .:|:.|
Zfish   441 SSLHDRIMFSPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGT 505

  Fly   448 VGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIF--- 508
            |||....:.|||:.::.| :.:...||.:|:|.|::|.|||...|||.|:|..|:.:|| ||
Zfish   506 VGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITKVGREDASSRQDIVLSGHFIKDEHC-IFTST 569

  Fly   509 ---LKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQ 570
               :..|.|.|.|...|:.:||...:.||..:..|:.|::|::::||||:|.:|.:.|:....:.
Zfish   570 TNAIGEGTVVLEPCEGAETYVNGKRVTEPTVLKSGNRIIMGKSHVFRFNDPEQARQDRERTPCAD 634

  Fly   571 LDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENA 635
            ..:..:....:.:|.|       ::.|..     .:|...||..     ||:|:.||..:...|.
Zfish   635 TPVEPVDWAFAQRELL-------EKQGID-----MKQEMDQRLQ-----ELEDQYRKEREEASNL 682

  Fly   636 LKQLNVERVQMHDQYKTKVRKLTEEL-------IRLEQEEMDGLQLLNCREQEL----------- 682
            |:|..::       |::|:..|.:::       ...|:||::.......||.||
Zfish   683 LEQQRLD-------YESKLEALQKQVNSRYYPETTEEEEELEDEVPWTKRETELALWAFRKWRFY 740

  Fly   683 --IARKDMLLW-------EKN------NEKVQIDIVCRQISAF----------QTQLDSKKRDFS 722
              .:.:| |||       |.|      .:|||...|....:.:          ....|.:||.|.
Zfish   741 QFTSLRD-LLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPSIAKDREKRLFP 804

  Fly   723 E-YVAKELQE-----------------------------------LQDCGKLDEMG--------- 742
            . .||.|:|:                                   ::||..:...|
Zfish   805 RTIVAVEVQDQKNGATHYWTLDKLRQRLDLMREMYDRAAEVPSTAVEDCDHIMSGGDPFYDRFPW 869

  Fly   743 MKIEEGTPLNDELLLQVSDSLDLFAAQFIKDT-------------VRRNNEEIRKLDEQIAEKER 794
            .::...||:.:..:.:....|.|.......|:             |....||:..||::|..::
Zfish   870 FRLVGRTPILNTCMSERMSGLTLSPTLSDPDSDITELADERHYGKVEVEEEELEDLDDEIFVED- 933

  Fly   795 ILNASTTKIAKVDE---------------------------------------TMLEIQAQLERL 820
              |.|  ::.:.:|                                       .:|.....:.|:
Zfish   934 --NGS--ELGREEEEDDDDGVGERCPGVSDGQDPFYDRWPLFSLVGRAFVYLSNLLYPVPLVHRV 994

  Fly   821 RLERAESEAES------QAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDT----FH 875
            .:...:.|.:.      ||:.|.::......|.:...|:..:.|.....|..| |.|.:    .|
Zfish   995 AIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFEDQAFEKFQT-EACTSGMSQTH 1058

  Fly   876 TAQSNLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSV 940
            |::..|.:|..    |||.|.|.                 || :.|..:.||...|.
Zfish  1059 TSEEELRIVEG----EGQNSELG-----------------LS-ADEVNNNTCLVSPD-------- 1093

  Fly   941 GIGGSGSAPSCTPSSQAIMSDS---GV--C-LDSRNQAILQNGHL---NNYKQAVRTSDEDTGSC 996
                              :|||   ||  | ||......||  ||   :|:  ..|.:.....|.
Zfish  1094 ------------------ISDSPLKGVLECPLDVTQDKSLQ--HLKIGSNF--TFRVTVLQASSI 1136

  Fly   997 SSCELGRHSDVARPYCPLHSLRRKIAAQKALIMK--------------NLETDLNKAQLD----- 1042
            |:    .::|:   :|..:.:.|...|.....:|              |:..::.|:.::
Zfish  1137 SA----EYADI---FCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNITVEVTKSFVEYIKSQ 1194

  Fly  1043 --------------------EHIADLQDLQRRYIQME-----------QEMLQSV-------QDL 1069
                                :.|:.|:.::|::.::.           ..:.:|.       .||
Zfish  1195 PIVFEVFGHYQKQPFPPLCKDLISSLRPMRRQFPRVMPLSKPVPATKLSTLARSTAGPCHCKYDL 1259

  Fly  1070 EAHAQCC------------ADERSGM--ERQYELASSIMRS---SVMSPTSMEESTSQIYSPSMT 1117
            .|..:.|            .|.|.||  ...:.|...|.|.   ::...|..:....::....:.
Zfish  1260 MAFFEICELEANGDYIPAVVDHRGGMPCHGTFLLHQGIQRRITVTIAHETGNDIEWKEVKELVIG 1324

  Fly  1118 RSCPSMREFPEGEHFITIPSF------------------VMRGAGKQTHYEYEVRIALPDGKLN- 1163
            |    :|..||.:..|..|:.                  |..|:..:|.|.:|   |..|..::
Zfish  1325 R----IRNTPEADETIIDPNILSLNILSSNYIRPTYDDRVSLGSDHRTFYRFE---AAWDSSMHN 1382

  Fly  1164 --ILRRYSRFRE-------LHLCMKHC-------------YGAKISALPFPR--RELFAS----- 1199
              :|.|.:.:.|       .:|.|::|             :.::.:.||..|  |.||::
Zfish  1383 SLLLNRVTPYGEKIYITLSAYLEMENCTQPTVVTKDFCMVFYSRDAKLPASRSIRNLFSTGAFRP 1447

  Fly  1200 --------------------NSEPVAKHRRRLLE---LYLR 1217
                                .|..:.:.|||:|:   .|:|
Zfish  1448 LESNCVTGVYELSLCHLADIGSPGMQRRRRRVLDTSVAYVR 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	200/374 (53%)
		KISc	3..371	CDD:214526	200/373 (54%)
		Kinesin_assoc	370..478	CDD:292801	44/176 (25%)
		FHA	456..555	CDD:238017	38/105 (36%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	28/158 (18%)
kif1ab	XP_009296795.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	200/374 (53%)
		KISc	5..361	CDD:214526	200/373 (54%)
		Kinesin_assoc	358..538	CDD:292801	44/179 (25%)
		FHA	515..618	CDD:238017	37/103 (36%)
		ATP-synt_B	<647..696	CDD:304375	16/72 (22%)
		KIF1B	828..874	CDD:289208	3/45 (7%)
		DUF3694	1320..1428	CDD:289256	19/114 (17%)
		PH_KIFIA_KIFIB	1680..1782	CDD:269939
		PH	1685..1778	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820