Protein Alignment Klp98A and kif17

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_001373250.1
• Gene: kif17 / 557863
• ZFINID: ZDB-GENE-080724-12
• Length: 823
• Species: Danio rerio
• Alignment Length: 1003
• Identity: 283/1003 - (28%)
• Similarity: 421/1003 - (41%)
• Gaps: 278/1003 - (27%)

  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAG--RDNHHDFTFDYSYWSFDA 65
            |:||.||.||.|:||..|:.::::.:::...:..      |:..|  .:....||||.:|:.
Zfish     5 SVKVVVRCRPLNNREKAMNCKIVVSVDSTHCQCF------IKKPGDTEEPPKQFTFDGTYYI--- 60

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNP---GLIPRICEEL 127
              .|  :.|:||:::...:|:...||||..:||||||||||:|||.|.|:.|   |:|||..|.:
Zfish    61 --NH--STEEVYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGVPDPPSQRGIIPRAFEHI 121

  Fly   128 FARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFD 192
            |..::..:  .|.:...|||||||.|.::||| .:.....:.::||...|.||.:|:...|....
Zfish   122 FETIQCAE--NTKFLVRASYLEIYKEEIRDLL-GKDIKQKMELKEHPERGVYVRDLTMQTVHSVG 183

  Fly   193 EIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSE--TVSKIHLVDLAGSERA 255
            |.:..:..|...|:...|.||..|||||:|||| .::...::....|  ...|::|||||||||.
Zfish   184 ECERVMDLGWRNRSVGYTLMNKDSSRSHSIFTI-HLEICSIDTAGDEHLRAGKLNLVDLAGSERQ 247

  Fly   256 NATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSI 320
            :.|||||.||:|...||.||..||:|||||.:                  |.||   |||||||.
Zfish   248 SKTGATGDRLQEATKINLSLSALGNVISALVD------------------GRSK---YIPYRDSK 291

  Fly   321 LTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREE 385
            ||.||:||||||::|:|:|.|||||.||.|::||||||||||:|.|:|.:|||....|:||.:||
Zfish   292 LTRLLQDSLGGNTRTLMVACLSPADNNYEESISTLRYANRAKSIQNRPRINEDPKDALLREYQEE 356

  Fly   386 INKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKV------LTEEWTEKWKVAQSILQEQKSLGLR 444
            |.||:::::|.:.|...| ..||..:..||...|      .:|...||.|:.:.  .|:|...|:
Zfish   357 IKKLRALISGQLGSGNLS-SFLAGQKSGEASAVVSRPQSNTSESEAEKDKIKEE--YEKKLARLQ 418

  Fly   445 KSGVGVVLDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFL 509
            ..     .|:|....:.:..|:....|.|     |||:.|.:              |::......
Zfish   419 AE-----YDAEQESKVKLQEDIAALRTSY-----ETRLSSLE--------------RSRGSRTHT 459

  Fly   510 KGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMS 574
            .|||               ||
Zfish   460 TGGV---------------HL-------------------------------------------- 465

  Fly   575 RLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRD-------DPELQDENRKILDTI 632
                 ...||..:|.|..|.|.....:...|     :||.|.|       ..|.|..:..::|..
Zfish   466 -----QQHKEEPITASAASQEQAKIDHSESE-----ERPSSVDATVKGAASGESQILDSVVVDIP 520

  Fly   633 ENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEK 697
            ....::|.:||:|                 :||||.:.|.|:   |.:||          |...|
Zfish   521 GQLDQKLALERLQ-----------------QLEQEFVGGEQV---RNEEL----------KQRHK 555

  Fly   698 VQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDS 762
            .:           :|..|.:|:..                ::.:....|:|    |.:||.|.||
Zfish   556 QR-----------KTLADQRKKQL----------------IEALNQSSEDG----DSVLLNVYDS 589

  Fly   763 LDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKI--AKVDETMLEIQAQLER------ 819
                                  :.|::..|.|.|..:..|:  ||::...|:.:.::||
Zfish   590 ----------------------IQEEVHAKSRHLENTQKKLKAAKLEIRDLQAEFEMERNDYLAT 632

  Fly   820 -LRLERAESEAESQAMRAKKQNMKLQLGNKSMSTST---STNEADDVSKSDTYETCDTFHTAQSN 880
             .||||     |.|.::...:.| :.|..:..:.|.   ...||....:..|:...|......:.
Zfish   633 IRRLER-----EGQLLQGILERM-VSLVRRDCNYSNLDRLRKEAVWDEEGGTWRLPDVLVQKTTL 691

  Fly   881 LSLVSSPTITEGQQSPLSNCSCD-----AEDEAEDTRKDDLSGSSEETSRTCTAGP--------- 931
            .::..|..|..|:.|...|.:.|     .::|.:|..|:.|:.|..|...|....|
Zfish   692 PAVPPSGVIAPGRLSARRNSASDLADPFVQEEEQDRYKEMLNRSDSEHIATNYFRPKRSSQLLAT 756

  Fly   932 ---------SSGSGSGSVGIGGSGSAPS 950
                     ||...:||.....|||..|
Zfish   757 DSVKNSMNFSSSVSNGSAHQSSSGSGLS 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	157/374 (42%)
		Kinesin_assoc	370..478	CDD:465047	31/113 (27%)
		FHA_KIF16	449..556	CDD:438760	15/106 (14%)
		SMC_N	624..>864	CDD:481474	48/251 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
kif17	NP_001373250.1	Motor_domain	4..335	CDD:473979	154/367 (42%)
		Smc	<398..>656	CDD:440809	80/441 (18%)