Protein Alignment Klp98A and KIF1A

DIOPT Version :9

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_001366560.1
• Gene: KIF1A / 547
• HGNCID: 888
• Length: 1816
• Species: Homo sapiens
• Alignment Length: 1621
• Identity: 432/1621 - (26%)
• Similarity: 683/1621 - (42%)
• Gaps: 536/1621 - (33%)

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDA- 65
            :|:|||||||||||||:..|::.|::|....|.::.|:      ..::....|:|||||||..:
Human     4 ASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPK------QPKETPKSFSFDYSYWSHTSP 62

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNNPGLIPRICEELF 128
            ||.::|:|:|||.|:|.:::..|:||||.|:|||||||:||::||||  ..:..|:||::||:||
Human    63 EDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLF 127

  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193
            :|:.........|....||:|||.|||:|||..::.|: ||||||..||||||:||:.||:.:::
Human   128 SRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGN-LRVREHPLLGPYVEDLSKLAVTSYND 191

  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVF--MNDMPSETVSKIHLVDLAGSERAN 256
            ||:.:..||..||.|:||||:|||||||:|.|.|.|...  ..::.:|.||||.||||||||||:
Human   192 IQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERAD 256

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            :|||.|.||||||:|||||.|||.|||||||...|.:.          |...|:..:||||||:|
Human   257 STGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNK----------NKKKKKTDFIPYRDSVL 311

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            ||||:::|||||:|.|:|||||||.||.|||||||||:|||.|.....:|||.|.||||||::|:
Human   312 TWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEV 376

  Fly   387 NKLKSML----AGDI---HSLQPSLKVLADLQ--------------------------------- 411
            .:|:.:|    .|||   :::....|.::||:
Human   377 TRLRDLLYAQGLGDITDTNTVPGGPKYVSDLENNNLNRGGTVNEAPDPLSTVTNALVGMSPSSSL 441

  Fly   412 ----------------------KKEAQEKV---------LTEEWTEKWKVAQSILQEQKSL---- 441
                                  .:||.|::         |.|.|.||.:..::|..|:::|
Human   442 SALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEM 506

  Fly   442 --GLRKSG--VGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIR 501
              .:|:.|  :||....:.|||:.::.| :.:...||.:|:|.||:|.||.:..|||.|:|..|:
Human   507 GVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIK 571

  Fly   502 AQHCSIF---LKGG---VVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAA 560
            .:|| :|   .:||   ||||.|...|..:||...:.||..:..|:.|::|::::||||:|.:|
Human   572 EEHC-VFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQA- 634

  Fly   561 KLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDEN 625
                                                      |.||:..|......:..:.....
Human   635 ------------------------------------------RQERERTPCAETPAEPVDWAFAQ 657

  Fly   626 RKILDTIENALKQLNVERVQ-MHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDML 689
            |::|:.....:||...:|:| :.|||:   |:..|....|||:.:|
Human   658 RELLEKQGIDMKQEMEQRLQELEDQYR---REREEATYLLEQQRLD------------------- 700

  Fly   690 LWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDE 754
             :|.            ::.|.|.|:||:   :...|.:|.:|.:     ||:     :.|....|
Human   701 -YES------------KLEALQKQMDSR---YYPEVNEEEEEPE-----DEV-----QWTERECE 739

  Fly   755 LLL---------QVSDSLDLF--AAQFIKDTVRRNNEEIRKLDEQIAEKERILNAST-------- 800
            |.|         |.:...||.  .|.|:|:....:.|..:|:..|.     :|...|
Human   740 LALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQF-----VLLTDTLYSPLPPD 799

  Fly   801 ---TKIAKVDET--------MLEIQAQ---------LERLRLERAESEAESQAMRAKKQNMKLQL 845
               .:.||..||        .:|:|.|         ||:||               ::.::..::
Human   800 LLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLR---------------QRLDLMREM 849

  Fly   846 GNKSMSTSTSTNEADD--VSKSDTY---------------ETCDTF---HTAQSN--LSLVSSPT 888
            .:::....:|..|..|  |:..|.:               ..|:::   :|..|.  .:|..|||
Human   850 YDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVGSSAISGCNSYPLLNTCMSERMAALTPSPT 914

  Fly   889 ITEGQQSPLSNCSCDA-----------EDEAEDTRKDDLSGSSEETSRTCTA------------- 929
            .:    ||.|:.:..|           |:|.||..::||..........|..
Human   915 FS----SPDSDATEPAEEQSVGEEEEEEEEEEDEEEEDLEDDVFPEHALCDGRDPFYDRPPLFSL 975

  Fly   930 ----------------------------------------------GPSSGSG---SGSVGIG-- 943
                                                          .|..|||   ||:..|.
Human   976 VGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFD 1040

  Fly   944 -------------------------------GSGSAPSCTPSSQAIMSDS-------GVCLDSRN 970
                                           |.|......||:..:.:::       |:.|||..
Human  1041 DQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSE 1105

  Fly   971 QAILQNGHLNNYKQAVRTSDEDT-------GSCSSCELGRHSDVARPYCPLHSLRRKIAAQKALI 1028
            :|.| :|.|:.....:|..:..|       .|..|.|   ::|:   :|..:.:.|...|.....
Human  1106 KAAL-DGPLDAALDHLRLGNTFTFRVTVLQASSISAE---YADI---FCQFNFIHRHDEAFSTEP 1163

  Fly  1029 MK--------------NLETDLNKAQLD----------------EH---------IADLQDLQRR 1054
            :|              |:..::.|:.::                :|         ::.|:..:|.
Human  1164 LKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRH 1228

  Fly  1055 YIQM-------------------------EQEMLQ--SVQDLEAHAQ---CCADERSGME--RQY 1087
            :.::                         :.::|.  .:.:|||:..   ...|.|.||.  ..:
Human  1229 FPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTF 1293

  Fly  1088 ELASSIMRSSVMSPTSMEESTSQI-YSPSMTRSCPSMREFPEGEHFITIPS----------FVMR 1141
            .|...|.|.  ::.|.:.|:.|.| :..........:|..||.:..:..|:          ::..
Human  1294 LLHQGIQRR--ITVTLLHETGSHIRWKEVRELVVGRIRNTPETDESLIDPNILSLNILSSGYIHP 1356

  Fly  1142 GAGKQTHYEYEVRIALPDGKLN---ILRRYSRFRE-------LHLCMKHC-------------YG 1183
            ....:|.|::|   |..|..::   :|.|.:.:||       .::.|::|             :.
Human  1357 AQDDRTFYQFE---AAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFY 1418

  Fly  1184 AKISALPFPR--RELFASNSEPVAKHRRRLLELYLRRLFVVCSKIPQCPIYEGPGGTGLTR 1242
            ::.:.||..|  |.||.|.|.. |....|:..:|         ::..|.:.:. |..|:.|
Human  1419 SRDAKLPASRSIRNLFGSGSLR-ASESNRVTGVY---------ELSLCHVADA-GSPGMQR 1468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	197/373 (53%)
		KISc	3..371	CDD:214526	197/372 (53%)
		Kinesin_assoc	370..478	CDD:292801	41/187 (22%)
		FHA	456..555	CDD:238017	40/105 (38%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	27/147 (18%)
KIF1A	NP_001366560.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820