DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and Klp54D

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	717	Identity:	204/717 - (28%)
Similarity:	305/717 - (42%)	Gaps:	195/717 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLKVAVRVRPFNSRE----------IDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFD 57
            ::.|.|||||.|.:|          ...:.|:|:|..:...:         |...||:...||::
  Fly   166 NINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDVGQK---------RSHNRDSVRVFTYN 221

  Fly    58 YSYWSFDAEDPHFATQEQV--YSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPN----- 115
            ..:      :|. ||||.:  ||.: ..:::...||::...|.|||||||||.|:.|.|:
  Fly   222 VVF------EPG-ATQEDILDYSGI-KRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGK 278

  Fly   116 -NP-----GLIPRICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVR-EH 173
             ||     |||.|....||..::  ......|...||::|||||||.|||...|....|.|| ..
  Fly   279 PNPKDPRHGLIFRSFLYLFQLIK--NRKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSK 341

  Fly   174 RSLGPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQ------AVF 232
            :|.|.:||||......:.|::...:..|...|...|..|||.|||||.|.|:..:.      .||
  Fly   342 KSGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHILSDQQTDGGVF 406

  Fly   233 MNDMPSETVSKIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSS 297
            ::..     .||:.|||||||....|.:.|:.|:|..:|||||:.||..||:|::
  Fly   407 LSKH-----GKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSD---------- 456

  Fly   298 SALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAK 362
                     :.||..:||||||.||.||.|||.||..|:|||.:|||..|::|||:|||||:|||
  Fly   457 ---------SKKRTGHIPYRDSQLTKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAK 512

  Fly   363 NIINKPTVNEDTNVKLIRELREEINKLKSMLAGDIHSLQ---PSLKVLADLQKKEAQEKVLTEEW 424
            .|..||.:..|....||..|:.           |||:||   ..||...:|..:.|......|
  Fly   513 RIRTKPVIKMDPREALILSLKR-----------DIHALQMENDHLKAALNLHHQAAPNGGPVE-- 564

  Fly   425 TEKWKVAQSILQEQKSLGLRKSGVGVVLD----SEMPHLIGIHNDVTTGVTLY-----SLKEGET 480
                    ::|:.|  |....||.||.:.    ..:|.|.|  :::...|.||     ||::...
  Fly   565 --------NLLELQ--LDRVSSGGGVPVPKVDLQRLPELDG--SELAELVKLYMVENESLRQENN 617

  Fly   481 RIGSEDADVAQDIELAGDGIRAQHC--------------SIFLKGGVVTLHP---------WPLA 522
            .:.:....:.:|.|:.        |              .:.::..::...|         .|..
  Fly   618 HLFTVRETILRDQEIV--------CRENERLLKKLEDVNKVCVRSPLIPARPAISPTTGKETPGT 674

  Fly   523 QCWVNAHLIDEPKQISQG-DIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSKENL 586
            :.|.|    .||.|...| |:.:..|.        :|.|..|.|.::.::|..|::      :|:
  Fly   675 EIWTN----PEPLQSPPGPDLPIEQRM--------SENANRRTDTAQKRIDQKRIA------KNI 721

  Fly   587 LTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLNVERVQMHDQYK 651
            |..        |:.:::|:                           .:..|:||:...:.|.:..
  Fly   722 LIM--------ANAFRKPD---------------------------SDITKELNLNPEEAHAKQS 751

  Fly   652 TK 653
            |:
  Fly   752 TE 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	147/397 (37%)
		KISc	3..371	CDD:214526	147/397 (37%)
		Kinesin_assoc	370..478	CDD:292801	29/119 (24%)
		FHA	456..555	CDD:238017	21/127 (17%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	147/396 (37%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	142/388 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437723
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940