Protein Alignment Klp98A and Kif28

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_001357826.1
• Gene: Kif28 / 383592
• MGIID: 2686151
• Length: 1033
• Species: Mus musculus
• Alignment Length: 1047
• Identity: 304/1047 - (29%)
• Similarity: 467/1047 - (44%)
• Gaps: 218/1047 - (20%)

  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNH-HDFTFDYSYWSFDA- 65
            |::||||||||:.||.:..:|.::.|.:...        ||||...:.. ..||||.:|||.|.
Mouse    16 SVRVAVRVRPFSQREKNSGSQCVISMHSGNI--------SIRDPKNEERVKTFTFDLTYWSHDGF 72

  Fly    66 ----------EDP--HFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPG 118
                      .||  .||.|..|:.|:|..::|.|:.||||.:.|||||||||:::|:|...|.|
Mouse    73 QKDEDGVLIPSDPASKFAGQSDVFHDIGRGILDSAWRGYNATLLAYGQTGSGKSYSMIGFGTNKG 137

  Fly   119 LIPRICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENL 183
            ||||:|||||..:. .|:.....:...|.||||||:::|||:......||||||.:.||.:||.|
Mouse   138 LIPRVCEELFQAIE-KQKENLEPQVMFSMLEIYNEQIRDLLSRTKAPGGLRVREDQQLGFFVEGL 201

  Fly   184 SQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVD 248
            ......::.:|::.:.:|:..|.|||||||.:|||||.:..|.|.| ||: |......|.|::||
Mouse   202 KWVPCENYAQIEKLVEQGSKIRMTASTNMNASSSRSHMLIAIQFKQ-VFL-DTALTKRSSINMVD 264

  Fly   249 LAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLY 313
            ||||||..::|:.|.||:||:.:|.||.:||:||||||:...|                 |:||:
Mouse   265 LAGSERQRSSGSEGDRLREGSRVNLSLTSLGNVISALADLAMG-----------------KKVLH 312

  Fly   314 IPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKL 378
            ||||||:||.||:.:|||||:|.:||||||||..|.|||||||||.|||.:.|:..:|   ...|
Mouse   313 IPYRDSVLTKLLQSALGGNSRTTLIAALSPADICYEETLSTLRYAERAKKVRNRAVIN---TCPL 374

  Fly   379 IRELREEINKLKSMLAGDIHSLQPS-LKVLADLQKKEAQEKVLTE---EWTEKWKVAQSILQEQK 439
            .|..|.| |.|.....|...:..|: ......|..:....::|.:   ||.|::   :::.||||
Mouse   375 ARASRAE-NALLLGFRGAGAAEHPACFWAEQQLGNQGTWAQLLEQARREWEEQY---EALTQEQK 435

  Fly   440 SLGLRKSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQ 503
            .:.:            :|||:.::.| ..|||..:.:..|...:|...::.   |.|.|.||..:
Mouse   436 MVRI------------LPHLLNVNEDPQLTGVLKFFIHNGSCDVGRAASNA---ICLQGLGISDK 485

  Fly   504 HCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRF-NNPAEAAKLRKDLS 567
            |.|.....|.||:.|....:..||...:....::...|.|:||..:.|.: ..|:|..  .:|||
Mouse   486 HASFVNLDGKVTVAPHSKCKVIVNGVPVTGRTKLQHLDRIILGSNSAFLYVGFPSERG--AEDLS 548

  Fly   568 RSQLDMSRLSLITSSKENLLTCSIYS-DEDGASP-YKRPERQYYPQRPMSRDDPELQDENRKILD 630
            |...|..:|....:...::.|....| .:|.|.| .....:.|....|:..:..::.:|.:|.|
Mouse   549 RFDYDFFQLERAAAEGVSVATLGCVSPGDDQADPSILAVFQDYVKLMPLVVEANQMSEELKKGL- 612

  Fly   631 TIENALKQLNVERVQMHDQYK---TKVRK-------------------LTEELIRLEQEEMDG-- 671
            |:|..:|.|.....:.:|..|   .||.|                   |.|||.:...|..|.
Mouse   613 TMELKVKNLASSDSRGYDLQKEVMVKVTKQGTHEVWIWSKAKFINRKFLMEELYQRFLESRDSHV 677

  Fly   672 -----------------------------------LQLLNCREQELIARKDMLL----------- 690
                                               ::.|||...|     :.:|
Mouse   678 AQEDDPFWDPLEVVHLGSAHVWLQPLAHCMMLEEQVEFLNCDGLE-----EAVLHIRITPCSPEG 737

  Fly   691 WEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYV-----AKELQELQDCGKLDEMGMKIEE--G 748
            |....|.:.||         ..:|..|:.||..::     .|.|:|  |..:..:||.||.:  .
Mouse   738 WAHGEEDMVID---------PLELLGKRIDFQTHIVRCLGVKWLKE--DGSRGIQMGYKIYDLPN 791

  Fly   749 TPLNDELLLQVSDSLD-------LFAAQFIKDTVRRNN--------EE------IRKLDEQIAEK 792
            |.....:...|:..::       |.|::...|.:..|.        :|      :.:||..:..:
Mouse   792 TLYTKPVWKSVNPRIEETVHFAALGASREFLDYLLTNALIVDLWGLQEGCAPLGVSQLDVLLTGE 856

  Fly   793 ERIL-------------NASTTKIAKVDETMLEIQAQLERLRLERAESEAESQAMRAKKQN---- 840
            ..|:             ..::.::.::.:.:|:::.:.|.||........|:..::|..:|
Mouse   857 GHIMVDTKTFSSVKDVSQITSNQVPELYQKLLKLEQETELLRDVNRALRGENVFLKASLENAGSA 921

  Fly   841 -MKLQLGNKSMSTSTSTNEADDV----SKSDTYETCDTFHTAQSNLSLVSSPTITEGQQSPLSNC 900
             ...:|.|...:|.|:..||..|    :.||.       ..|::.........:..||...|..|
Mouse   922 PQAQKLDNPEGATRTAAREAKQVCAQQASSDA-------QLARALKVFYQGMGVARGQLLRLRRC 979

  Fly   901 SCDAEDE 907
            ....:|:
Mouse   980 RPPEDDQ 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	173/381 (45%)
		Kinesin_assoc	370..478	CDD:465047	25/112 (22%)
		FHA_KIF16	449..556	CDD:438760	27/108 (25%)
		SMC_N	624..>864	CDD:481474	63/359 (18%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Kif28	NP_001357826.1	Motor_domain	15..370	CDD:473979	173/381 (45%)
		FHA_KIF28P	441..538	CDD:438761	27/99 (27%)
		KIF1B	655..693	CDD:463574	6/37 (16%)