DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp98A and KIF22

DIOPT Version :10

Sequence 1:NP_524532.2 Gene:Klp98A / 43310 FlyBaseID:FBgn0004387 Length:1265 Species:Drosophila melanogaster
Sequence 2:NP_015556.1 Gene:KIF22 / 3835 HGNCID:6391 Length:665 Species:Homo sapiens


Alignment Length:671 Identity:189/671 - (28%)
Similarity:276/671 - (41%) Gaps:181/671 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LKVAVRVRPFNSREID-----MDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSF 63
            ::||||:|||    :|     .|...:..|::          .|:..|...||.: |..|.:.:|
Human    44 VRVAVRLRPF----VDGTAGASDPPCVRGMDS----------CSLEIANWRNHQE-TLKYQFDAF 93

  Fly    64 DAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELF 128
            ..|.   :||:.:|:.....::....||.||.|.|||.||:|||.||:|:|..||:|||...:| 
Human    94 YGER---STQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDL- 154

  Fly   129 ARMRVGQESGTGYRTHA-----SYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAV 188
              :::.:|.|...|..|     ||||||.|:|.|||...|  ..|.:||.......:..|||..:
Human   155 --LQLTREEGAEGRPWALSVTMSYLEIYQEKVLDLLDPAS--GDLVIREDCRGNILIPGLSQKPI 215

  Fly   189 SDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQ----AVFMNDMPSETVSKIHLVDL 249
            |.|.:.:......:..||..:|.:|..||||||:..:...|    |.|     .:...|::|:||
Human   216 SSFADFERHFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPF-----RQREGKLYLIDL 275

  Fly   250 AGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYI 314
            ||||....||..|.||||...||.||..||.|:.||                   |....||   
Human   276 AGSEDNRRTGNKGLRLKESGAINTSLFVLGKVVDAL-------------------NQGLPRV--- 318

  Fly   315 PYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTN---- 375
            |||||.||.||:|||||::.:|:||.::|....|.:|:|.|.:|.|:|.:||:|..||...    
Human   319 PYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTNESLQPHAL 383

  Fly   376 --VKLI-REL-------------REEINKLKSMLA-----------GDIHSLQPSL--------K 405
              |||. :||             .|||...:.|.|           ..:.|:.|::        :
Human   384 GPVKLSQKELLGPPEAKRARGPEEEEIGSPEPMAAPASASQKLSPLQKLSSMDPAMLERLLSLDR 448

  Fly   406 VLA---------------------------DLQ-------KKEAQEKVLTEEWTEKWKVAQSILQ 436
            :||                           ||:       :||.:.|:|.::..||.....::|:
Human   449 LLASQGSQGAPLLSTPKRERMVLMKTVEEKDLEIERLKTKQKELEAKMLAQKAEEKENHCPTMLR 513

  Fly   437 ---EQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGD 498
               .:...|.:.....||    ||..:......:....::.||....:...|..|..:..|.|.|
Human   514 PLSHRTVTGAKPLKKAVV----MPLQLIQEQAASPNAEIHILKNKGRKRKLESLDALEPEEKAED 574

  Fly   499 GIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLR 563
                                     ||        ..|||. :::..||..|....|...|..||
Human   575 -------------------------CW--------ELQISP-ELLAHGRQKILDLLNEGSARDLR 605

  Fly   564 KDLSRSQLDMSRLSLITSSKE 584
               |..::...:..||...:|
Human   606 ---SLQRIGPKKAQLIVGWRE 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp98ANP_524532.2 KISc_KIF1A_KIF1B 2..371 CDD:276816 136/380 (36%)
Kinesin_assoc 370..478 CDD:465047 32/183 (17%)
FHA_KIF16 449..556 CDD:438760 19/106 (18%)
SMC_N 624..>864 CDD:481474
PX_KIF16B_SNX23 1131..1259 CDD:132784
KIF22NP_015556.1 KISc_KID_like 43..366 CDD:276827 132/371 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 379..428 10/48 (21%)
ComEA 596..646 CDD:441164 8/31 (26%)
Blue background indicates that the domain is not in the aligned region.

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