Protein Alignment Klp98A and KIF11

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_004514.2
• Gene: KIF11 / 3832
• HGNCID: 6388
• Length: 1056
• Species: Homo sapiens
• Alignment Length: 1100
• Identity: 288/1100 - (26%)
• Similarity: 475/1100 - (43%)
• Gaps: 267/1100 - (24%)

  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAG---RDNHHDFTFDYSYWSFD 64
            :::|.||.||||..|....|..|:|.:..:..:      |:|..|   :.:...:|||..:.:
Human    18 NIQVVVRCRPFNLAERKASAHSIVECDPVRKEV------SVRTGGLADKSSRKTYTFDMVFGA-- 74

  Fly    65 AEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNN---------PG 118
                 ...|..||..:...::|....|||..:|||||||:||||||.|  :||.         .|
Human    75 -----STKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAG 134

  Fly   119 LIPRICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSL------- 176
            :|||...::|.::   .::||.:....|.||||||.:.|||...|.     |.|...:
Human   135 IIPRTLHQIFEKL---TDNGTEFSVKVSLLEIYNEELFDLLNPSSD-----VSERLQMFDDPRNK 191

  Fly   177 -GPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSE- 239
             |..::.|.:..|.:.||:.:.:.:|.|:||||:|.||..|||||::|::|    :.|.:...:
Human   192 RGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVT----IHMKETTIDG 252

  Fly   240 ----TVSKIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSAL 300
                .:.|::||||||||....:||..:|.:|..:||:||:|||.||:||.|:|.
Human   253 EELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTP---------- 307

  Fly   301 ATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNII 365
                        ::|||:|.||.:|:|||||.::|.:||.:|||..|..||||||.||:|||||:
Human   308 ------------HVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL 360

  Fly   366 NKPTVNED-TNVKLIRELREEINKLKSMLA-----GDIHSLQPSLKVLA-DLQKKEAQ-----EK 418
            |||.||:. |...||:|..|||.:||..||     ..::..:.:.:|:: .|..:|.|     ||
Human   361 NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEK 425

  Fly   419 V---------LTEEW-----------------TEKWKVAQSILQEQKSLGLRKSGVGVVLDS--E 455
            :         :||.:                 |::.:..|..|||.|...:::..:...|:|  |
Human   426 IGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEE 490

  Fly   456 MPH-----LIGIHNDVTTGVT-LYSLKEGETRIGSEDADVAQDI-------------ELAGDGIR 501
            ..|     |:....:.|..|: |:|..:.:..:...:|: ||||             ||..||..
Human   491 KLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAE-AQDIFGKNLNSLFNNMEELIKDGSS 554

  Fly   502 AQ------HCSIF---LKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNN-- 555
            .|      |.::|   |...|..|........   ..|...|:.:|         |::.:..|
Human   555 KQKAMLEVHKTLFGNLLSSSVSALDTITTVAL---GSLTSIPENVS---------THVSQIFNMI 607

  Fly   556 ------PAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPM 614
                  .||:..:.::|    :::.:..|: ||.|.:|:.::.|.....|..|     :..:..:
Human   608 LKEQSLAAESKTVLQEL----INVLKTDLL-SSLEMILSPTVVSILKINSQLK-----HIFKTSL 662

  Fly   615 SRDDPELQDENRKI---LDTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLN 676
            :..| :::|:.:::   |..:.|.|.:|....:....:.:.:...|||:|..::|
Human   663 TVAD-KIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQ---------- 716

  Fly   677 CREQELIARKDMLLW-------EKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQD 734
            ...|||.  |.|.||       |:..|.:|     :.:|:.|..:..|.:|....:....|:.
Human   717 THSQELC--KLMNLWTERFCALEEKCENIQ-----KPLSSVQENIQQKSKDIVNKMTFHSQKF-- 772

  Fly   735 CGKLDEMGMKI----EEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERI 795
            |...|....::    :|||.|.:| .::.||.|               |..:.|:.::..::...
Human   773 CADSDGFSQELRNFNQEGTKLVEE-SVKHSDKL---------------NGNLEKISQETEQRCES 821

  Fly   796 LNASTTK-----IAKVDE------TMLEIQAQ-LERLRLERAESEAESQAMRAKKQNMKLQL--- 845
            ||..|..     ::.::|      .:||:.:| .|....:..|.....:|...|:.|:.|..
Human   822 LNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTI 886

  Fly   846 -GNKSMSTSTSTNEADDVS--------KSDTYETCDTFHTAQSNLSLVSSPTI-TEGQQSPLS-- 898
             .:|.::.:...||...:.        :.|......|..|.|....|..|..: ||.::..|.
Human   887 DEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQL 951

  Fly   899 -----------NCSCDAEDEAEDTRKD-DLSGS--SEETSRTCTAGPSSGSGSGSVGIGG 944
                       |||   |:..|:|..| |:..:  .:.|....:..||..:|.....|||
Human   952 KRKQPELLMMLNCS---ENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGG 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	143/394 (36%)
		Kinesin_assoc	370..478	CDD:465047	36/153 (24%)
		FHA_KIF16	449..556	CDD:438760	29/144 (20%)
		SMC_N	624..>864	CDD:481474	52/277 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	145/396 (37%)
		PRK12704	350..>508	CDD:237177	43/157 (27%)
		YhaN	380..>761	CDD:443752	85/421 (20%)
		Microtub_bind	916..1053	CDD:464048	23/95 (24%)