Protein Alignment Klp98A and KIF3C

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_002245.4
• Gene: KIF3C / 3797
• HGNCID: 6321
• Length: 793
• Species: Homo sapiens
• Alignment Length: 786
• Identity: 231/786 - (29%)
• Similarity: 340/786 - (43%)
• Gaps: 228/786 - (29%)

  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67
            :|||..|.||.:.:|.....:.|:.|:   .:|.:..|::.|.|..:....||||..|   ||.
Human    10 ALKVVARCRPLSRKEEAAGHEQILTMD---VKLGQVTLRNPRAAPGELPKTFTFDAVY---DAS- 67

  Fly    68 PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGT---PNNPGLIPRICEELFA 129
               :.|..:|.:....::|...:|:|..||||||||:|||:||.||   |...|:||...|.:|.
Human    68 ---SKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFT 129

  Fly   130 RMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEI 194
              .:.:.....|...|||||||.|.::||| ::..|..|.::|:...|.|:::||.....:..||
Human   130 --HISRSQNQQYLVRASYLEIYQEEIRDLL-SKEPGKRLELKENPETGVYIKDLSSFVTKNVKEI 191

  Fly   195 QECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSE-----TVSKIHLVDLAGSER 254
            :..:..||..|...||:||:.||||||||.||    |..::..|:     .|.|::|||||||||
Human   192 EHVMNLGNQTRAVGSTHMNEVSSRSHAIFIIT----VECSERGSDGQDHIRVGKLNLVDLAGSER 252

  Fly   255 AN----------AT--------------GATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNS 295
            .|          ||              ||.|:|.||.:.||.||..||:||:|||     |:.|
Human   253 QNKAGPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALA-----GNRS 312

  Fly   296 SSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANR 360
            :                :||||||.||.||:||||||:||||:|.|.||..:|.|:|||||:|||
Human   313 T----------------HIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANR 361

  Fly   361 AKNIINKPTVNEDTNVKLIRELREEINKLKSML-AGDIHSLQPSLKVLADLQKKEA-------QE 417
            ||||.|||.||||....|:||.:|||.:||:.| ...:...:|..|   ..::|:|       .|
Human   362 AKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRK---SSRRKKAVSAPPGYPE 423

  Fly   418 KVLTEEW--------TEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTTGVTLYS 474
            ..:.|.|        ....:..|.||:.             .|:..|.:.
Human   424 GPVIEAWVAEEEDDNNNNHRPPQPILES-------------ALEKNMENY--------------- 460

  Fly   475 LKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQ 539
            |:|.:.|:..|.|.:..|                                   ..|:.|.||
Human   461 LQEQKERLEEEKAAIQDD-----------------------------------RSLVSEEKQ--- 487

  Fly   540 GDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRP 604
               .||           .|..|:.:||.|.|.....|                     |:.||..
Human   488 ---KLL-----------EEKEKMLEDLRREQQATELL---------------------AAKYKAM 517

  Fly   605 ERQYYPQRPMSRDDPELQDENRKILDTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEM 669
            |             .:|....|.|:|......|.|.::|.::.:| |.:.|::.:|::..::|.|
Human   518 E-------------SKLLIGGRNIMDHTNEQQKMLELKRQEIAEQ-KRREREMQQEMMLRDEETM 568

  Fly   670 DGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDF----SEY--VAKE 728
            :........:||                  :::..:::.....:|.:.|.:.    .||  |.::
Human   569 ELRGTYTSLQQE------------------VEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQD 615

  Fly   729 LQELQD 734
            |:|.|:
Human   616 LEEAQN 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	160/399 (40%)
		Kinesin_assoc	370..478	CDD:465047	26/123 (21%)
		FHA_KIF16	449..556	CDD:438760	14/106 (13%)
		SMC_N	624..>864	CDD:481474	22/117 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
KIF3C	NP_002245.4	KISc_KIF3	9..365	CDD:276822	155/392 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..288		9/36 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..424		5/32 (16%)
		Smc	<452..>635	CDD:440809	48/290 (17%)
		Globular. /evidence=ECO:0000255	630..793
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	750..793