Protein Alignment Klp98A and Khc-73

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Alignment Length: 1258
• Identity: 376/1258 - (29%)
• Similarity: 569/1258 - (45%)
• Gaps: 255/1258 - (20%)

  Fly     4 LKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLK-PRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67
            :||||||||||.|||::|.:.|:|||.::|.|.. |.|:.|.   |.....|.||:.::|.:.||
  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIE---RKQPKTFAFDHCFYSLNPED 67

  Fly    68 PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFARMR 132
            .:||:||.|:..:|..::|.|::|||||:||||||||||::|||||..:.|:|||:|::||:.:.
  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIA 132

  Fly   133 VGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQEC 197
            ........|:...||:|||||:|.|||..:.....|:||||..:||||:.|||.||:.:.:|...
  Fly   133 NKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNL 197

  Fly   198 IARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMND----MPSETVSKIHLVDLAGSERANAT 258
            :..||..||.|:||||..||||||:|::...|  .:.|    :..|.||::.||||||||||..|
  Fly   198 MTEGNKSRTVAATNMNAESSRSHAVFSVVLTQ--ILTDQATGVSGEKVSRMSLVDLAGSERAVKT 260

  Fly   259 GATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTW 323
            ||.|.|||||::|||||.|||.|||.||:|:.|..:.:..              ::|||||:|||
  Fly   261 GAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDK--------------FVPYRDSVLTW 311

  Fly   324 LLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINK 388
            ||||:|||||:|:|:|.:||:..||.|||||||||:|||.|:|...||||.|.::|||||.|:..
  Fly   312 LLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVET 376

  Fly   389 LKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWK---VAQSILQEQKSLGLRKSGV-- 448
            |:|||.....|      .:.|:|.|.|:.:.|.::.::.|:   |....:|.::...|.|.|:
  Fly   377 LRSMLKHATGS------PVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISV 435

  Fly   449 ---GVVLDSEMPHLIGIHNDVTTG-VTLYSLKEGETRIGSEDADVAQ-DIELAGDGIRAQHCSIF 508
               |:.::....:|:.::.|.:.. :.:|.||: .|.||.......| ||:|:|.||:.:||.|.
  Fly   436 QASGIKVEKNKYYLVNLNADPSLNELLVYYLKD-RTLIGGRTISGQQPDIQLSGLGIQPEHCVIT 499

  Fly   509 LKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDM 573
            ::...:.:.|...|:|:||.....|...:..||.||.|..:.||.|:|
  Fly   500 IEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP----------------- 547

  Fly   574 SRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPEL-QDE---NRKILDTIEN 634
                     |.|  ..|:.:.|              ||.|....|... :||   |....|.|:.
  Fly   548 ---------KSN--NTSMCASE--------------PQTPAQLIDYNFARDEIMQNELSNDPIQT 587

  Fly   635 ALKQLNVERVQMHDQYKTKVRKLTEELIRLEQE---------------EMDGLQLLNCREQELIA 684
            |:.:|  || |..:..:..:.|..:|..|..|:               ..|.|::.........:
  Fly   588 AIARL--ER-QHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTS 649

  Fly   685 RKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGT 749
            :..:..|.:..:::           |:..|...|.|...  |..|  :|:...|.|   ::|:.|
  Fly   650 QMRVEKWAQERDEM-----------FRRSLGQLKTDIMR--ANSL--VQEANFLAE---EMEKKT 696

  Fly   750 PLNDELLLQVSD-SLDLFAAQFIKD---TVRRNNE-----EIRKLDEQIAE--------KERILN 797
            ..:..|.:..:: |.:.....|:.:   .|:|.|.     .:.||:.::.:        |||:||
  Fly   697 KFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLN 761

  Fly   798 ASTTKIAKVDETMLEIQAQ----------LERL----RLE--------------RAESEAESQAM 834
            ......||..:...|.|..          ||.|    :|:              |.:.|.|..|.
  Fly   762 GLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAG 826

  Fly   835 RAKKQNMKLQLGNKSMSTSTSTNEADD-VSKSDTYETCDTFHTAQSNLSLVSSPTI-----TEGQ 893
            :..:..|   ..:.|.|:..|.:|.|| |..:....||.......|.|.|..|..:     ..|.
  Fly   827 QMPQDRM---CESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGH 888

  Fly   894 QS---PLSNCSCDAEDE-----AEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPS 950
            |.   |:.|....|.|:     .|.| :|.....:||....|..|..|....|....|.|.:...
  Fly   889 QEMVVPVINAESTAHDQNMVFKFEHT-QDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGW 952

  Fly   951 CTPSSQA---IMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDVARPYC 1012
            .....||   .:.|....|..:.:..::...||           |.|..|..|:...::|...
  Fly   953 EVEQQQAKARSLVDRWAELSRKIELWVEIHELN-----------DNGEYSPVEVTNRNEVLTG-- 1004

  Fly  1013 PLHSLRR---------------------------KIAAQKALIMKNLETDLNKAQ------LDEH 1044
            .::.||:                           .:|.....:...|:..|:..|      |.|.
  Fly  1005 GIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREK 1069

  Fly  1045 IADLQDLQRRYIQMEQEMLQSVQDLEAHAQCCADERSGMERQYELASSIMRSSVMSPTSMEESTS 1109
            .::....:|:|:..:.:||..           .:|::..||:.||      |.|....|:.|..:
  Fly  1070 WSEALGRRRQYLDQQIQMLIK-----------KEEKNEQEREREL------SLVHQWVSLTEERN 1117

  Fly  1110 QIYSP---SMTRSCPSMREFPEG 1129
            .:..|   |.....|:..|.|.|
  Fly  1118 AVLVPAPGSGIPGAPASWEPPSG 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	185/371 (50%)
		Kinesin_assoc	370..478	CDD:465047	33/116 (28%)
		FHA_KIF16	449..556	CDD:438760	33/108 (31%)
		SMC_N	624..>864	CDD:481474	60/303 (20%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	185/371 (50%)
		Kinesin_assoc	356..468	CDD:465047	32/117 (27%)
		FHA_KIF13	446..547	CDD:438758	32/101 (32%)
		KIF1B	741..786	CDD:463574	10/44 (23%)
		DUF3694	989..1243	CDD:463599	30/171 (18%)
		CAP_GLY	1785..1850	CDD:460154