DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and Kif14

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_038947257.1	Gene:	Kif14 / 360849	RGDID:	1310650	Length:	1672	Species:	Rattus norvegicus

Alignment Length:	1335	Identity:	397/1335 - (29%)
Similarity:	583/1335 - (43%)	Gaps:	325/1335 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAE 66
            |.:.||||||||:.||....|..::....::..:..|.::.|        :.|.:|.::||||..
  Rat   392 SQVTVAVRVRPFSKREKTEKASQVVFRNGEEITVEHPDMKQI--------YSFIYDVAFWSFDEC 448

  Fly    67 DPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFARM 131
            .|.:|.|..||..|...::|.|:||||.|:||||||||||::||||....||:|||.||:|||::
  Rat   449 HPGYANQTTVYETLAAPLLDRAFEGYNTCLFAYGQTGSGKSYTMMGLNEEPGIIPRFCEDLFAQI 513

  Fly   132 RVGQESGTGYRTHASYLEIYNERVKDLLAAQSTG----HGLRVREHRSLGPYVENLSQHAVSDFD 192
            ...|.|...|....|:.|:|||::.|||..:...    ..||||||...|||||.||.:.||.:.
  Rat   514 AKKQASEVSYHLEMSFFEVYNEKIHDLLVCKGENGQRKQPLRVREHPVSGPYVEGLSMNVVSSYS 578

  Fly   193 EIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQA----VFMNDMPSETVSKIHLVDLAGSE 253
            :||..:..||.||.||:|.|||.|||||::||:...|.    |...:......|:|:|:||||||
  Rat   579 DIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSE 643

  Fly   254 RANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRD 318
            |.:...::|:|||||..|||||:|||.|||||:||..|                 ||| :||||:
  Rat   644 RCSTAHSSGERLKEGVSINKSLLTLGKVISALSEQANG-----------------KRV-FIPYRE 690

  Fly   319 SILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELR 383
            |.||||||:||||||||.|||.:|||..|..|||||||||.:|:.|:|...||||.|.||||||:
  Rat   691 STLTWLLKESLGGNSKTAMIATISPAASNIEETLSTLRYATQARLIVNVAKVNEDMNAKLIRELK 755

  Fly   384 EEINKLKSMLAGDIHSLQP-----------SLKVLADLQKKEAQEKVLTEEWTEKWKVAQS-ILQ 436
            .||.|||:..... .::.|           ||::....|:::..|  :...|.||::.|:. .||
  Rat   756 AEIEKLKAAQKSS-RNIDPERYRLCRQEISSLRMKLHQQERDMAE--IQRVWKEKFEQAEKRKLQ 817

  Fly   437 EQKSLGLRKSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGI 500
            |.|.  |:|:||...:|:.:|:|:.::.| ..:.:.||.:|||.|.:|....:.:.||:|:|..|
  Rat   818 ETKE--LQKAGVTFQMDNHLPNLVNLNEDPQLSEMLLYMVKEGITTVGKHTPNSSHDIQLSGVLI 880

  Fly   501 RAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKD 565
            ...||:|...||.|::.|...|:.:||...|.||..:..||.::||..:.||||:|.|..|.:|
  Rat   881 ADDHCTIRSYGGTVSIVPAGEAKTYVNGMHISEPTVLHHGDRVVLGGDHYFRFNHPVEVQKGKK- 944

  Fly   566 LSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILD 630
            .||:.|..........:|..||..                     ||  ||.:.|::|...|..:
  Rat   945 TSRNNLTSEGPKDFEFAKNELLAA---------------------QR--SRLEAEIKDAQLKAKE 986

  Fly   631 TI--------ENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKD 687
            .:        |.|.::|:.:|.    .|:.|:|.|..||                ||:....|
  Rat   987 EMMQGIQIAKEMAQQELSSQRA----AYENKIRALEAEL----------------REESQRKR-- 1029

  Fly   688 MLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSE--YVAKELQELQDCGKLDEMGMKIEEGTP 750
              |.|.||:|....|         .:|:..|:...:  ||.|...|::
  Rat  1030 --LEEINNQKASHKI---------EELEKAKQHLEQEVYVNKRRLEME----------------- 1066

  Fly   751 LNDELLLQVSDSLDLFAAQFIKD-TVR--RNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLE 812
                         .|...|.::| .:|  |..|.:.:..::|||:.:||..:.....|.    ..
  Rat  1067 -------------TLATKQALEDHRIRHARILEALEREKQKIAEEVQILQENRGNRNKT----FT 1114

  Fly   813 IQAQLERLRLERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSD----------- 866
            ||.....::|.....||.:.:.:.||..:            ...::|.|..:||
  Rat  1115 IQPNWSSMKLSTMIQEANAISDKFKKHYV------------FGRHDASDKGRSDPSVRVRNLQLG 1167

  Fly   867 --TYETCDTFHTAQSNL-SLVSSPTITEGQQSPLSNCSCDAEDEAE-DTRKDDLSGSSEETSRT- 926
              |:...:.|.:..:.: .|..|.:.|.|:     :..||.|||.| |.....:|..|...||:
  Rat  1168 ISTFWNLEKFESKLAAMKDLYESNSGTRGE-----DVFCDPEDEWEPDITSTPVSSLSRRRSRSL 1227

  Fly   927 --------C--------TAGPSSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGVC-------LDS 968
                    |        :..||..|        |....||...|:.:.....|:|       :|.
  Rat  1228 MKNRRVSGCLHDIHPIQSMHPSHTS--------GLMEKPSTIYSNSSESFLPGICKELIGSSIDF 1284

  Fly   969 RNQAI---------LQNGHLNNYKQAVRTS------DEDTG----------------SCSSCE-- 1000
            ..|:.         |.|..|..|...:..|      ||::.                :|:..:
  Rat  1285 LGQSFDEEKTIADSLINNLLKLYNGVIAISKAHEEQDEESQDNVFSDRAAQALTIQVACAFEQLV 1349

  Fly  1001 -LGRH--------SDVARPYCPLHSLRRKIAAQKALIMKNLETDL--------NKA-----QLDE 1043
             |.:|        |..||....|....:|:.....|.::...:|:        ||.     |...
  Rat  1350 VLFKHWLDDFPPCSGSARLEEELRQDIKKLGGYLQLFLQGCCSDISSMVKEAQNKVTEIIQQAVG 1414

  Fly  1044 HIADLQDLQ---------RRYIQMEQEMLQSVQDLEAHA-QCCADERSGMERQYELASSIMRSSV 1098
            |:|.|..|:         ...:...||::.::||..|.. :...|  ||:|...||...:.|.|.
  Rat  1415 HVAQLAVLKGSKLCVLEDSNKVSSAQELMAALQDGTASGMRSLLD--SGLETAQELRQDVSRQSA 1477

  Fly  1099 -------MSPTSME--ESTSQIYSPSMTRSCPSMREFPEGEHFITIPSFVMRGAGKQTHYEYEVR 1154
                   |...::|  .|...|::...|:|..:..|  ||.          |..|.:
  Rat  1478 PEEVTRQMKANAVELVGSLENIFAEWRTKSFRTQVE--EGS----------RQQGSK-------- 1522

  Fly  1155 IALPDGKLNILRRYSRFRELHLCMKHCYGAKISAL 1189
                     :|...|.|.:|..|::......:|||
  Rat  1523 ---------VLNLASEFLKLKSCLQQTIEMVVSAL 1548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	177/376 (47%)
		KISc	3..371	CDD:214526	176/375 (47%)
		Kinesin_assoc	370..478	CDD:292801	40/120 (33%)
		FHA	456..555	CDD:238017	35/99 (35%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	10/59 (17%)
Kif14	XP_038947257.1	KISc_KIF1A_KIF1B	392..743	CDD:276816	177/376 (47%)
		Kinesin_assoc	740..859	CDD:406567	41/123 (33%)
		FHA	838..935	CDD:238017	34/96 (35%)
		SMC_prok_B	<956..>1107	CDD:274008	46/236 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920