Protein Alignment Klp98A and klp-20

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_497178.1
• Gene: klp-20 / 3565057
• WormBaseID: WBGene00002230
• Length: 646
• Species: Caenorhabditis elegans
• Alignment Length: 737
• Identity: 216/737 - (29%)
• Similarity: 323/737 - (43%)
• Gaps: 158/737 - (21%)

  Fly     4 LKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAEDP 68
            :||.||.||.::.| .:....|....|.:.:.:..:..|..|..|..:.|..|          .|
 Worm     7 VKVVVRCRPISTTE-KLQGHKIAVTCNDEEKAVNIKSLSQEDPPRTFYFDAVF----------SP 60

  Fly    69 HFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG---TPNNPGLIPRICEELFAR 130
            : ..|..||:.....:|:...:|||..:|||||||:||||||.|   .....|:||.....:|..
 Worm    61 N-TDQMTVYNVAARPIVENVLKGYNGTIFAYGQTGTGKTFTMAGDLEPVEMRGIIPNSFAHIFDH 124

  Fly   131 MRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQ 195
            :...|.. |.:....||||||||.::|||:....|: |.::|...:|.||.|||...|.:..::|
 Worm   125 IAKCQHD-TTFLVRVSYLEIYNEEIRDLLSKDHNGN-LEIKERPDVGVYVRNLSNPTVENASKMQ 187

  Fly   196 ECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDLAGSERANATGA 260
            ..:..|:..|...:|.||..||||||:||:|....  .|.:  .|..|:.|||||||||.:.|||
 Worm   188 ALMEFGSKNRKVGATAMNLESSRSHAMFTVTIESC--RNGL--VTQGKLQLVDLAGSERQSKTGA 248

  Fly   261 TGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLL 325
            .|:||||.|.||.||.|||:|||:|.:                  |.|   .:||||:|.||.||
 Worm   249 QGERLKEAAKINLSLSTLGNVISSLVD------------------GKS---THIPYRNSKLTRLL 292

  Fly   326 KDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKLK 390
            :|||||||||:|||.:.||..||.|||||||||||||||.|...:|||.....:|:.:.||..|:
 Worm   293 QDSLGGNSKTVMIANVGPATYNYDETLSTLRYANRAKNIQNVAKINEDPKDAQLRKFQLEIEALR 357

  Fly   391 SML----AGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVV 451
            .:|    .||            |..::||.|..:.|...|..| .:.||:|:.:..:
 Worm   358 KILDEENPGD------------DENQEEAWEAKMQEREVEMEK-KRKILEERVNSAV-------- 401

  Fly   452 LDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTL 516
                        ||..|...:..:.|.|..:..               .|::|..:..|...:
 Worm   402 ------------NDEETHRLVKEMMENEAELKK---------------ARSEHEKLRSKLEKI-- 437

  Fly   517 HPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKL----RKDLSRSQLDMSRLS 577
                            |.|.|..|:.:|         ....|.|||    .|:|.:|:...:.|
 Worm   438 ----------------EKKLIVGGENLL---------EKVEEQAKLLEVNNKELEQSKFQEAHL- 476

  Fly   578 LITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDE---NRKILDTIENALKQL 639
              .:..|......:..:|..:|                     ||:|   ..|.:..:.|.||..
 Worm   477 --RTQLEERTAVKVEIEERYSS---------------------LQEEAFVKSKKIKKVSNELKDA 518

  Fly   640 NVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLN----CREQELIARKDMLLWEKNNEKVQI 700
            ..|...:.:.::.:|..:.:::.:|.:|.:..:.:::    ....|||.:  .:.|.:.:...|:
 Worm   519 RAELKDLEEDHQRQVEAMLDDIRQLRKELLLNIAIIDEYIPVEHVELIEK--YVSWSEEHGDWQL 581

  Fly   701 DIVCRQISAFQTQLDSKKRDFS 722
            ..:....:..:......|::||
 Worm   582 KAIAYTGNNMRASAPPAKKEFS 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	153/369 (41%)
		Kinesin_assoc	370..478	CDD:465047	23/111 (21%)
		FHA_KIF16	449..556	CDD:438760	13/106 (12%)
		SMC_N	624..>864	CDD:481474	17/106 (16%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
klp-20	NP_497178.1	Motor_domain	5..331	CDD:473979	150/362 (41%)
		Smc	<325..>556	CDD:440809	63/329 (19%)