DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and CG14535

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	1309	Identity:	258/1309 - (19%)
Similarity:	419/1309 - (32%)	Gaps:	430/1309 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSLKVAVRV--RPFNSREIDMDAQLIMEMENKKTR--LLKPRLQSIRDAGRDNHHD-------F 54
            :..:||.:||  |..||...:.|   .|.::.||.:  |..||..............       |
  Fly    42 VGKVKVMLRVADRDRNSGGTEPD---FMALDKKKRQVTLTDPRTACPPPQAAQERAPMVAAPKMF 103

  Fly    55 TFDYSYWSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGL 119
            .||.   .|..||    .|..|.:...::|:....||.:.|:.|.|...:|:..|::|
  Fly   104 AFDN---LFTGED----KQSDVCASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLG------- 154

  Fly   120 IPRICEELFARMRVGQESGTGYRTHAS---------YLEIYNERVK------------------- 156
                  ||......|..||:|......         |..|...|.|
  Fly   155 ------ELGGGSGSGSASGSGVACSLGAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGVSATKP 213

  Fly   157 -----DLL---AAQS-TGHGLRVREHRSLGP--YVENLSQHAVSDFDEIQECIARGNAQRTTAST 210
                 |||   ||:| ...|:.:|:....||  .....::.|....|  .....|..:..:|||.
  Fly   214 DALSQDLLISHAAESDDSPGIYLRDDFLGGPTELRAPTAERAALFLD--SALAGRLKSSGSTASG 276

  Fly   211 NMNDTSS-RSHAIFTITFVQ-AVFMNDMPSETVSKIHLVDLAGSERANATGATGQRLKEGAHINK 273
            :....:. .|..|||:...| ::......:...|::|::||.|.  ||..|..
  Fly   277 SSGCAAPLESALIFTLHVYQYSLSRKGGVAGGRSRLHIIDLGGC--ANRNGGL------------ 327

  Fly   274 SLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMI 338
            .|..:|:::  ||..:|..|.                    |::|..||.||||.|...:..:.|
  Fly   328 PLSGIGNIL--LAILSGQRHP--------------------PHKDHPLTPLLKDCLAPITCHVAI 370

  Fly   339 AALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKLKSMLAGDIHSLQPS 403
            .|....:.:|.:.|||::.|:|                  |..||...:::...||..:
  Fly   371 VAHVRPEQSYQDALSTIQIASR------------------IHRLRRRKHRVPMPLAVGL------ 411

  Fly   404 LKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTT 468
                                       ||.:.....|.|.........:.::....:|.::|.|.
  Fly   412 ---------------------------AQGLGGNGSSAGSGADPSSSEISADTVIYMGPNDDATD 449

  Fly   469 G----VTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAH 529
            |    |.|.||..|:.|                 |:.::    .|||..:...|
  Fly   450 GEHPPVYLPSLTAGDNR-----------------GVMSK----ALKGSGLEKPP----------- 482

  Fly   530 LIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSD 594
                .|..|...:::          ..|.||:..|.|..|.         |.|.:.
  Fly   483 ----SKSASNSPMMM----------KKAMAAEKAKKLPGSH---------TGSLKR--------- 515

  Fly   595 EDGAS-------PYKRPERQY------YPQR--------------PMSRDDP-----ELQDENRK 627
            :.||.       |:::|:.|.      .|:.              ||.|..|     :|:...||
  Fly   516 QAGAGACSSPMIPHEQPQIQAMGSPIPIPRHMVSKGSMVPSPKGSPMRRAHPGAALEQLEAGMRK 580

  Fly   628 ILDTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEE--MDGLQLLNCREQELIA------ 684
            |  |.|..:....|.|.::     .:.|.|..|:..::|.|  :||.:..:||  .|.|
  Fly   581 I--TEEQWIDGPRVSRAKV-----AEARHLMREVNHVKQCETWVDGPKSQSCR--SLTACNLPAA 636

  Fly   685 --------------RKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDC 735
                          :|.|:.....|:..|:         ||:.:.:.....:.:
  Fly   637 GGSQTQGYGFMDAHKKTMIRQWVENQTTQV---------FQSTVSASNSPTALH----------- 681

  Fly   736 GKLDEMGMKIEEGTPLNDELLLQVSDSLDL----FAAQFIKDTVRRNNEE------------IRK 784
            .||.::..|   ...|.|........||||    |.:..:.|....:.:|            :..
  Fly   682 WKLSQLKQK---SLDLPDRPAFNPEPSLDLNQPCFESLPLLDPAPPDGDEDEDSGPSEVPPALPL 743

  Fly   785 LDEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAESEAESQAMRAKKQ--------NM 841
            ||:.:..::    .|...:.:    ||......|:|.      |||..|.||...        :.
  Fly   744 LDDPLGSRD----ISQDNLHR----MLSRHVSREQLH------EAELVASRASSSHHPSQRSIDC 794

  Fly   842 KLQLGNKSMSTSTSTNEADDVSKS--DTYETCDTFHTAQSNLSLVSSPTITEGQQSPLSNCSCDA 904
            .||:..:.::.:.|.:...|.|..  .....||       |:|.|||           .|.:|::
  Fly   795 GLQVTEEEIARTMSRDRDHDPSAHPLSALSHCD-------NISFVSS-----------FNMACES 841

  Fly   905 EDEAEDTRK---DDLSGSSE-ETSRTCTA--GPSSG---SGSGSV--------GIGGSG--SAPS 950
            ..|..:..:   |.|:...| .||:...|  .||:.   :..|||        .:|.|.  |.|:
  Fly   842 FSECGERARQQFDQLARLHEIFTSQLAMAEVTPSAALFRTDIGSVFSEPVYHFNVGQSSVCSEPA 906

  Fly   951 --CTPS--SQAIMSDSGVCLDSRNQAILQNGHLNNY---KQAVRTSDEDTGSCSSCELGRHSDVA 1008
              .|||  .|...|.|...|.|.| .|::...:::|   :|....||.:..........:|.|:
  Fly   907 YRLTPSPPKQPSHSPSQGSLPSLN-GIMEIAGMDDYALLRQPDGASDPNLQKGEKRFTPQHDDI- 969

  Fly  1009 RPYCPLHSLRRKIAAQKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQMEQEMLQSVQDLEAHA 1073
               |.|.......|..|...:::.:..||:......:|....|....:....|...|..|..:..
  Fly   970 ---CELDEKSMAAAVGKGNSLEDAQHKLNEITNILPLAAQSRLPLLPLNTSSEAYDSGHDSNSTP 1031

  Fly  1074 QCCADERSGMERQYELASSIMRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGEHFITIPSF 1138
            :  ..:.||:.|:.|       |...|..::.:|....::..|::.         ..|.||:
  Fly  1032 R--TSKHSGISRRAE-------SGYHSVATVRDSDESSFASGMSKG---------QRHRITV--- 1075

  Fly  1139 VMRGAGKQT 1147
              .|.|..|
  Fly  1076 --SGTGAVT 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	93/420 (22%)
		KISc	3..371	CDD:214526	93/419 (22%)
		Kinesin_assoc	370..478	CDD:292801	17/111 (15%)
		FHA	456..555	CDD:238017	17/102 (17%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	6/17 (35%)
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	93/428 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100