DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp98A and nod

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster

Alignment Length:	833	Identity:	198/833 - (23%)
Similarity:	320/833 - (38%)	Gaps:	253/833 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSLKVAVRVRPFNS----REIDM-------DAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDF 54
            :|::::|||..|:..    ||..:       |.:.::..:|                      :|
  Fly     6 LSAVRIAVREAPYRQFLGRREPSVVQFPPWSDGKSLIVDQN----------------------EF 48

  Fly    55 TFDYSYWSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGT------ 113
            .||:::       |...:|:::|..|...:||...||:.....||||||:||:::|..|
  Fly    49 HFDHAF-------PATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEIL 106

  Fly   114 PNNPGLIPRICEELFARMRVGQESG-TGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLG 177
            |.:.|::||...::|.|:...||:. ...:.:||::|||||:..|||.  ||.|          .
  Fly   107 PEHLGILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLLG--STPH----------M 159

  Fly   178 PYVENLSQ-------HAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMND 235
            |.|....|       |:.:|...|.|.   |...|....||||..|||||||.||         .
  Fly   160 PMVAARCQRCTCLPLHSQADLHHILEL---GTRNRRVRPTNMNSNSSRSHAIVTI---------H 212

  Fly   236 MPSET-VSKIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSA 299
            :.|:| .|::::|||||||....||..|...:||.:||..|:::..|:.::|    .||.
  Fly   213 VKSKTHHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMA----AGHT----- 268

  Fly   300 LATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNI 364
                         .||||||:||.:|:.||...|....:|.:||..|:.||||||||:...||.:
  Fly   269 -------------VIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKL 320

  Fly   365 -INKPTV---NEDTNVKLIRELREEI---NKLKSMLAGDIHSLQPSLKV---------------- 406
             :|...|   .:....:.....|:.:   ..:||..|.....:.|..|.
  Fly   321 RLNPMQVARQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVPKSKYSTTKPLSAVLHRTRSE 385

  Fly   407 --LADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTTG 469
              :....||.|:|.:..||.|          .|..|:.::.|.:.         |:|.|:|
  Fly   386 LGMTPKAKKRARELLELEETT----------LELSSIHIQDSSLS---------LLGFHSD---- 427

  Fly   470 VTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEP 534
                           .|.|              :|           |.|.|..|         ||
  Fly   428 ---------------SDKD--------------RH-----------LMPPPTGQ---------EP 443

  Fly   535 KQISQGDIILLGRTNIFRFNNPAEAAKLRKDL--------SRSQL---DMSRLSLITSSKENLLT 588
            :|.|..:..|:|   |.....|.|::|:::.:        .|.||   .:|.:||..||.:..|:
  Fly   444 RQASSQNSTLMG---IVEETEPKESSKVQQSMVAPTVPTTVRCQLFNTTISPISLRASSSQRELS 505

  Fly   589 CSIYSDEDGASPYKRPERQYYPQRPMSRDDPEL----QDENRKILDTIENALKQLNVERVQMHDQ 649
                    |..|.:... ...||:|..|....|    :.:|...:..:.|..:...:..::.|
  Fly   506 --------GIQPMEETV-VASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLRRSTRLAGIREH-- 559

  Fly   650 YKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQL 714
                   .|..:::.|.:.:..|:....:::....:.....|..||.|..:|::
  Fly   560 -------ATSVVVKNETDAIPHLRSTVQKKRTRNVKPAPKAWMANNTKCFLDLL----------- 606

  Fly   715 DSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDSLDLFA 767
                   :....|:|||:...|......:.:........|.|.||. ||.:::
  Fly   607 -------NNGNVKQLQEIPGIGPKSAFSLALHRSRLGCFENLFQVK-SLPIWS 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	123/398 (31%)
		KISc	3..371	CDD:214526	122/397 (31%)
		Kinesin_assoc	370..478	CDD:292801	21/131 (16%)
		FHA	456..555	CDD:238017	18/98 (18%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
nod	NP_001285129.1	KISc	8..325	CDD:214526	121/391 (31%)
		KISc	8..318	CDD:276812	118/384 (31%)
		ComEA	540..648	CDD:224472	20/135 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030