DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp98A and Klp10A

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	152/525 - (28%)
Similarity:	220/525 - (41%)	Gaps:	145/525 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LKVAVRVRPF-----NSREIDM------DAQLIMEMENK--KTRLLKPRLQSIRDAGRDNHHDFT 55
            :.|.||.||.     |.:|||:      |..::.|..:|  .|:.|:             :|.|.
  Fly   279 ITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLE-------------NHKFR 330

  Fly    56 FDYSYWSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNP--- 117
            |||::  .|..|     ...||......:|...:||..|..|||||||||||.||.|..|..
  Fly   331 FDYAF--NDTCD-----NAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQD 388

  Fly   118 ---GLIPRICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPY 179
               |:.....:::|..:.:.:.........||:.|||:.:|.|||   |....|||.|.......
  Fly   389 CKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLL---SDKQKLRVLEDGKQQVQ 450

  Fly   180 VENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKI 244
            |..|::..|...:|:.:.|..|||.||:..|:.|..||||||:|.|.         :..:..:||
  Fly   451 VVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIV---------LRPQGSTKI 506

  Fly   245 H----LVDLAGSER-ANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTP 304
            |    .:||||:|| .:.:.|..|...|||.|||||:.|...|.||.:|:.
  Fly   507 HGKFSFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSA-------------- 557

  Fly   305 NGASKRVLYIPYRDSILTWLLKDS-LGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKP 368
                    ::|:|.|.||.:|:|| :|..|||.|||.:||...:...||:|||||:|.|.::.|.
  Fly   558 --------HLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVKD 614

  Fly   369 TV----NEDTNVKLIR--ELREEINKLKSMLAGDIHSLQPS------------------------ 403
            .|    ..||....|.  |..||:|    |:....|.|.|:
  Fly   615 IVEVCPGGDTEPIEITDDEEEEELN----MVHPHSHQLHPNSHAPASQSNNQRAPASHHSGAVIH 675

  Fly   404 ----------------LKVLADLQKKEAQEKVL-----------TEEWTEKW-----KVAQSILQ 436
                            |.:|:.|.:.|..::::           |||...::     ...::.|.
  Fly   676 NNNNNNNKNGNAGNMDLAMLSSLSEHEMSDELIVQHQAIDDLQQTEEMVVEYHRTVNATLETFLA 740

  Fly   437 EQKSL 441
            |.|:|
  Fly   741 ESKAL 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	130/395 (33%)
		KISc	3..371	CDD:214526	130/395 (33%)
		Kinesin_assoc	370..478	CDD:292801	23/134 (17%)
		FHA	456..555	CDD:238017
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	127/382 (33%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	125/378 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940