Protein Alignment Klp98A and Kif6

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_796026.2
• Gene: Kif6 / 319991
• MGIID: 1098238
• Length: 802
• Species: Mus musculus
• Alignment Length: 813
• Identity: 218/813 - (26%)
• Similarity: 352/813 - (43%)
• Gaps: 159/813 - (19%)

  Fly     3 SLKVAVRVRPFNSRE------IDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHD-FTFDYSY 60
            ::::..||:|...::      ||.|.:|...:|     ::.||  .:.|...:|..: :.|.:..
Mouse     5 TIQIFARVKPTVRKQQQGIYSIDEDEKLTHSLE-----IVLPR--DLADGFVNNKRESYKFKFQR 62

  Fly    61 WSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTP---NNPGLIPR 122
             .||.|    |.||.::..:...|.:....|||..:|||||||||||||:.|..   ::.|:|||
Mouse    63 -IFDQE----AKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPR 122

  Fly   123 ICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLR------VREHRSLGPYVE 181
            ....:|.:::  ::|...|.||.||||||||...|||..:.....|.      :.|......:::
Mouse   123 TLSYIFEQLQ--KDSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQNIHLK 185

  Fly   182 NLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETV--SKI 244
            |||.|..:..:|....:..|:..|..|.|.||..|:|||.|||:    .:...:..|.||  :|:
Mouse   186 NLSLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTV----HLSSKEPGSATVRHAKL 246

  Fly   245 HLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASK 309
            ||||||||||.:.||..|..|.|..:||.||..|..||.||:|                     |
Mouse   247 HLVDLAGSERVSKTGVGGLLLTEAKYINLSLHYLEQVIIALSE---------------------K 290

  Fly   310 RVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDT 374
            ...:||||:|::|.:|:||||||..|.|||.||....|..|::||.|:|.|...|.|:..:||:.
Mouse   291 HRTHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRNIDESISTCRFAQRVALIKNEAILNEEI 355

  Fly   375 NVKL-IRELREEINKLKSMLA-----------GDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEK 427
            :.:| |..|::||..||:.||           .:...||....:.:.|:.::.:.::  |...:.
Mouse   356 DPRLMIVRLQKEIEDLKAELAMATGEQRTEALTEAELLQLEKLIASYLEDQDPESRL--EVGADM 418

  Fly   428 WKV------AQSILQEQKSL-------GLRKSGVGVVLDSEMPHLIGI----HNDVTTGVTLYSL 475
            .|:      .:.:|.::|:|       ..|::....:.|.|...|:|:    .|::...|.:...
Mouse   419 RKIHHCFHHFKKLLNDKKTLENTVSSESTRQACQEPLRDEEYTKLLGLLKQRDNEINILVNMLKK 483

  Fly   476 KEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVT---------LHPWPLAQCWVNAHLI 531
            ::.:|:      |..|:..|.....|....|.|:.|....         .|...|:.|...:.|:
Mouse   484 EKKKTQ------DALQNSSLEKSDTRPPQNSPFIAGSPAVPRTPFSSAPSHTQDLSICRHRSSLL 542

  Fly   532 DEPKQISQGDIILLGRTNIFRF--NNPAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSD 594
            .  |:....:.:.|||...|..  .:.|::..:.   ...|:...|.     |:...|..||...
Mouse   543 H--KKTGMREEMSLGRQEAFEIFKRDHADSVTIE---DNKQVLKQRF-----SEAKALGESINEA 597

  Fly   595 EDGASPYKRPERQYYPQR----------PMSRDDPELQDENRKILDTIENALKQLNVERVQMHDQ 649
            .......|....|.:.|:          |.|..||  |:|..:         .||..|:    .:
Mouse   598 RSKIGQLKDAINQRHLQQVALGISENTVPASTPDP--QEEKLR---------AQLEEEK----GR 647

  Fly   650 YKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCRQ----ISAF 710
            |||....|     :..:.|::.||||..:.:..:.::....|.:....:|::.....    :..|
Mouse   648 YKTAFMHL-----KALKVEIEHLQLLMDKAKVKLQKEFEAWWAEEATSLQVNSPATNLQDAVKPF 707

  Fly   711 ----QTQLDSKKRDFSEYVAKELQELQDCGKLD 739
                |.||.|||.      :::|:.....|:|:
Mouse   708 PQQDQAQLLSKKS------SRDLEVENGAGRLE 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	135/385 (35%)
		Kinesin_assoc	370..478	CDD:465047	26/136 (19%)
		FHA_KIF16	449..556	CDD:438760	23/121 (19%)
		SMC_N	624..>864	CDD:481474	25/124 (20%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Kif6	NP_796026.2	KISc_KIF9_like	5..343	CDD:276826	133/376 (35%)
		GumC	<557..>726	CDD:442439	39/202 (19%)