DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and Klp3A

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster

Alignment Length:	1319	Identity:	325/1319 - (24%)
Similarity:	529/1319 - (40%)	Gaps:	301/1319 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGR---DNHHDFTFDYSYWSF 63
            |.:.||:||||....|:|...::.:|             :|...|.:   :.:..:|::|   .|
  Fly     7 SCVAVALRVRPLVQSELDRGCRIAVE-------------RSADGAPQVTVNRNESYTYNY---VF 55

  Fly    64 DAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNN------PGLIPR 122
            |.:|    :|:.::.......|.....|||..:.||||||||||:| |||..|      .|:|||
  Fly    56 DIDD----SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPR 115

  Fly   123 ICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHG---LRVREHRSLGPYVENLS 184
            ...::|..: ...:|...:....|::|:|.|:..||.::::....   :|..::|.:.|   .|:
  Fly   116 AVHDIFTAI-AEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GLT 176

  Fly   185 QHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDL 249
            :..|:...::.:.:.||:|.|..|:|.||:||||||||||:|.| |..::...|.|.|:.:||||
  Fly   177 ELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLV-ATKLDGKQSVTTSRFNLVDL 240

  Fly   250 AGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYI 314
            |||||.:.|.|:|.|.|||.:|||.|:.||:||:||                    |:.:...||
  Fly   241 AGSERCSKTLASGDRFKEGVNINKGLLALGNVINAL--------------------GSGQAAGYI 285

  Fly   315 PYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLI 379
            |||.|.||.||:|||||||.|:|||.:||||.|.:|||||||||:||..|.|||.||.|.:...:
  Fly   286 PYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEV 350

  Fly   380 RELREEINKLKSML----------------------------------AGDIHSLQPSLKVLADL 410
            ..|::.|.||:..|                                  |.:|..|:..::.|.|.
  Fly   351 NMLKDVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDR 415

  Fly   411 QKK---EAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTTG--- 469
            .:|   |..:.:|  :.|||...|....|....|....|.:...||.......|  |:.|.|
  Fly   416 NRKLQQELHQSLL--DLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFG--NENTNGDNE 476

  Fly   470 VTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCS-IFLKGGV-------VTLHPWPLAQCWV 526
            :..:||.  ..|:..|.....:::|..|...|.:..| ...:||.       ..||..  ::.:.
  Fly   477 MRDFSLL--VNRVHVELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSH--SEEYT 537

  Fly   527 NAHLIDEPKQIS-QGDIILLGR-------------TNIFRFNNPAEAAKLR------KDLSRSQL 571
            |       ||:: .|::..:.|             .|..|.::..|..|||      .||...:.
  Fly   538 N-------KQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERR 595

  Fly   572 DMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENAL 636
            |:  :..:.:.|...::..:..:       :|...|...|        |:.|..||:: |..|.|
  Fly   596 DL--MDQLRNIKSKDISAKLAEE-------RRKRLQLLEQ--------EISDLRRKLI-TQANLL 642

  Fly   637 KQLNVERVQMHDQYKTKVRKLTEELIRL------EQEEMDGLQLLNCREQELIARKDMLLWEKNN 695
            |..:.||.::.: ..|::|.:.|..::|      |.|:.        |:.:::..|::...:..:
  Fly   643 KIRDKEREKIQN-LSTEIRTMKESKVKLIRAMRGESEKF--------RQWKMVREKELTQLKSKD 698

  Fly   696 EKVQIDIVCRQISAFQTQLDSKKRDFSEYVA-----KELQELQDCGKLDEMGMKIEEGTPLND-- 753
            .|:|.:|| ||.:....|....||...|.:|     |:..|.|...:......|...|:....
  Fly   699 RKMQSEIV-RQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSN 762

  Fly   754 -------------ELLLQVSD---SLDLFAAQFIKDTVRRNN------EEIRKLDEQIAEKERIL 796
                         |::|.:.|   ||:    |.::|....||      :|......:.||:.|||
  Fly   763 ANAKTDSWVDRELEIILSLIDAEHSLE----QLMEDRAVINNHYHLLQQEKTSDPAEAAEQARIL 823

  Fly   797 NASTTKIAKVDETMLEIQAQL------ERLR--LERAESEAES-----QAMRAKKQNMKLQLGNK 848
            .:...::...:..:.::|.::      .|:|  .|..:|..||     |.::...|..:||..:.
  Fly   824 ASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSL 888

  Fly   849 SMSTST--------------------------STNEADDVSKSDTYE--TCDTFHTAQSNLSLVS 885
            :...:|                          |.:|...:::...||  ......||....:...
  Fly   889 NEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEAR 953

  Fly   886 SPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSS-------GSGSGSVGIG 943
            ||  .|.||.........:..||.....|.|...::..|:...:.|..       ..|:.:|.:.
  Fly   954 SP--AEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLS 1016

  Fly   944 GSGSAPSCTPS---SQAIMSDSGVCL-----DSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCE 1000
            .....|...||   |:.|.|||...:     ...|...|.|..:.:......|  ||...|..|:
  Fly  1017 DVSDDPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSAT--EDGKRCKGCK 1079

  Fly  1001 LGRHSDVARPYCPLHSLRRKIAAQKALIMK-NLETDLNKAQLDEHIA----------DLQDLQRR 1054
            ........|..|    |....|..:..:.| |....||   |.:|.:          :.:|..:.
  Fly  1080 CRTKCTTKRCGC----LSGNNACSETCVCKSNCRNPLN---LKDHASQCGDGDGQKDETEDADKS 1137

  Fly  1055 YIQMEQEMLQSVQDL------EAHAQCCADERSGMERQYELASSIMRSSVMSPTSMEESTSQIYS 1113
            ....:.|...|.::.      ||..:..|..:..::.....|:.:|.|:|:         ..|..
  Fly  1138 DDDGDDEPQTSKENAVKFVTPEAPGKVVASPKQTLQEPKAAATPLMNSNVV---------EDING 1193

  Fly  1114 PSMTRSCPSMREFPEGEHF 1132
            |.:.:......:.|:.:.|
  Fly  1194 PKLAKMSGLAFDTPKRKFF 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	146/380 (38%)
		KISc	3..371	CDD:214526	145/379 (38%)
		Kinesin_assoc	370..478	CDD:292801	31/147 (21%)
		FHA	456..555	CDD:238017	23/123 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	1/2 (50%)
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	142/374 (38%)
		Kinesin	14..335	CDD:278646	139/366 (38%)
		Smc	<396..>994	CDD:224117	128/646 (20%)
		FlaC	522..633	CDD:225888	22/136 (16%)
		TCR	1075..1110	CDD:281618	8/38 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437732
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840