Protein Alignment Klp98A and Kif16b

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_038960967.1
• Gene: Kif16b / 311478
• RGDID: 1310146
• Length: 1876
• Species: Rattus norvegicus
• Alignment Length: 1271
• Identity: 472/1271 - (37%)
• Similarity: 654/1271 - (51%)
• Gaps: 232/1271 - (18%)

  Fly    12 PFNSREIDMDAQLIMEMENKKTRL--LKPRLQSIRDAGRDNHHDFTFDYSYWSFDAEDPHFATQE 74
            |.:.:|.|::|:.|::||..||.:  ||.......|:||:....||:|:|::|.|.:.|.:.:||
  Rat    15 PMSKQEKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDFSFYSADTKSPDYVSQE 79

  Fly    75 QVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFARM-RVGQESG 138
            .|:..||.|||..|:|||||||||||||||||::||||...:.||||||||.||:|: ...:...
  Rat    80 TVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEALFSRINETTRWDE 144

  Fly   139 TGYRTHASYLEIYNERVKDLLAAQST-GHGLRVREHRSLGPYVENLSQHAVSDFDEIQECIARGN 202
            ..:||..||||||||||:|||..:|: ...||||||...|||||:||:|.|.::.:::|.:..||
  Rat   145 ASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYSDVEELMDAGN 209

  Fly   203 AQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDLAGSERANATGATGQRLKE 267
            ..||||:|.|||.||||||||||.|.||.|..:||.|||||||||||||||||:||||||.||||
  Rat   210 INRTTAATGMNDVSSRSHAIFTIKFTQAKFDAEMPCETVSKIHLVDLAGSERADATGATGVRLKE 274

  Fly   268 GAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGN 332
            |.:|||||||||:||||||:.:....|..          ..|:.:::|||||:||||||||||||
  Rat   275 GGNINKSLVTLGNVISALADLSQDAANPL----------VKKKQVFVPYRDSVLTWLLKDSLGGN 329

  Fly   333 SKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKLKSMLA-GD 396
            |||||||.:||||.||.||||||||||||||||||||:|||.|||||||||.||.:||::|| |:
  Rat   330 SKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGN 394

  Fly   397 IHSLQPS---LKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPH 458
            ..:|..|   |.:...|.:.||:.:.||:|||.||...|:||:|| :|.|||.|:|||||||:||
  Rat   395 QIALLDSPTALSMEEKLHQNEARVQELTKEWTNKWNETQNILKEQ-TLALRKEGIGVVLDSELPH 458

  Fly   459 LIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHPWPLA 522
            ||||.:| ::||:.||.||||:|.:|.|||...|||.|.|..:.::||.....||.|||.|...:
  Rat   459 LIGIDDDLLSTGIILYHLKEGQTYVGREDASTEQDIVLHGLDLESEHCVFENAGGTVTLIPLSGS 523

  Fly   523 QCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSK--EN 585
            ||.||...|.:..|::||.:|||||||:||||:|.||||||:......|....||:...||  ||
  Rat   524 QCSVNGVQIVDATQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSCEN 588

  Fly   586 LLTCSIYSDEDGASPYKRP-------ERQYYPQRPMSRDDPELQDENRKILDTIENALK--QLNV 641
            |....:|:  .|..|.|.|       |||       .|::.|..:..||:::.:|...|  :..:
  Rat   589 LSAVMLYN--PGLFPMKGPICLRLEFERQ-------QREELEKLESKRKLIEEMEEKQKSDKAEL 644

  Fly   642 ERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQL-LNCREQELIARKDMLLWEKNNEKVQIDIVCR 705
            ||:|...:.:.|..::.:..||.::|.:..... :..:.::|:|.|:....|:..|
  Rat   645 ERMQQEVETRRKETEIVQRQIRKQEESLKRRSFHIENKLKDLLAEKERFEEERLRE--------- 700

  Fly   706 QISAFQTQLDSKKR---DFSEYVAKELQELQDCGKLDEMGMKIEEGTPLND-ELLLQVSDSLDLF 766
                 |..|:.:||   |....:.:||:.||:....::    .|:|.||.| :.|.:..|
  Rat   701 -----QQGLEQQKRQEEDSFFRIREELRRLQELNSHEQ----AEKGQPLQDLDWLHREQD----- 751

  Fly   767 AAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLE-------------IQAQLE 818
             ||..|..:     |.|:|:||  |||::|     ::|.::|.:.:             .|||.|
  Rat   752 -AQSAKLQL-----EKRRLEEQ--EKEQVL-----RVAHLEEQLRKRQDTAPLLCPGEAQQAQEE 803

  Fly   819 RLRLE--------------------RAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVS 863
            |..||                    |.|.|...|.....|:...::|         :|.|.|.|.
  Rat   804 RRELEGIRGALLQAKEIRAGGDHTFRGELERAQQYFLEFKRRQLVKL---------ATLEKDLVQ 859

  Fly   864 KSD---------------------------TYETC---------DTFHTAQSNL--------SLV 884
            :.|                           ..:.|         |...||:|.|        .|:
  Rat   860 QKDRLSKEVQEEKEALEHVKCEAGEEPSLLATDNCNILCGPQDLDKIKTAESRLQSKEHQLQDLL 924

  Fly   885 SS--PTITEGQQSPLSNCSCDA---------------EDEAEDTRKDDLSGSSEETSRTCTAGPS 932
            .:  |.:.|.:|..|....|..               |.|.:.|:....:...::...|.....:
  Rat   925 QNHLPALLEEKQRVLEILDCGVLGLDNILYHVEKEMEEKEEQITQYQANASQLQQLQATVQFTAN 989

  Fly   933 SGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNYKQAVRT------SDE 991
            .......|.........|.....:..:..:...|:.|:.|:.:...|:...|..|.      |.|
  Rat   990 VARQEEKVRRKEKEILESQEKQQREALEQAVAKLEQRHSALKRRSTLDLEIQEQRQKLGSLHSSE 1054

  Fly   992 DTGSCSSCELG---RHSDVARPYCPLHSLRRKIAAQKALIMKNLETDLNKAQL--------DEHI 1045
            ..|..:|.|..   ...|.||....:|.|::||.....:...:..|...||.|        :.|:
  Rat  1055 WPGLQASLEANGERLQMDPARIEHEIHELKQKICEVDGVQRPHHGTLEGKAALSSLPPSAENSHL 1119

  Fly  1046 ADLQDLQ-RRYIQMEQEMLQSVQDLE------AHAQCCADERSGME---------RQYELASS-- 1092
            |.|.|.: ..||  |:|:.:.:.||.      :||.  |:.:|..|         .:||....
  Rat  1120 APLMDARISAYI--EEEVQRRLHDLHRVISDASHAP--AELKSNEELHNGATQRKLKYEKGQPWS 1180

  Fly  1093 -------IMRSSVMSPTSMEESTSQIYSPSMTRSCP 1121
                   :.:.:|.||:.:.|. |::| ||...|.|
  Rat  1181 ARCGIPLLPKDAVDSPSVLGEE-SEVY-PSSQWSHP 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	215/362 (59%)
		Kinesin_assoc	370..478	CDD:465047	62/112 (55%)
		FHA_KIF16	449..556	CDD:438760	59/107 (55%)
		SMC_N	624..>864	CDD:481474	63/279 (23%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Kif16b	XP_038960967.1	KISc_KIF1A_KIF1B	15..368	CDD:276816	215/362 (59%)
		Kinesin_assoc	367..479	CDD:465047	62/112 (55%)
		FHA	449..565	CDD:469597	65/115 (57%)
		Smc	<609..>1087	CDD:440809	103/529 (19%)