DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and Kif13b

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_998791.1	Gene:	Kif13b / 305967	RGDID:	1303307	Length:	1767	Species:	Rattus norvegicus

Alignment Length:	1326	Identity:	393/1326 - (29%)
Similarity:	588/1326 - (44%)	Gaps:	269/1326 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFD-A 65
            |.:||||||||.|.||||:..:.::::|..|..|........:...|.....|.:|:.:||.| :
  Rat     4 SKVKVAVRVRPMNRREIDLHTKCVVDVEANKVILNPINTNLSKGDARGQPKIFAYDHCFWSMDES 68

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFAR 130
            ....:|.|:.|:..||.:::..|::|||||:||||||||||::|||||.:.||||||:|..||.|
  Rat    69 VREKYAGQDDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGLFER 133

  Fly   131 MRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQ 195
            .:..:.....::...||:|||||:|:|||..:.:...|:||||..|||||:.||:.||:.:.:|:
  Rat   134 TQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIE 198

  Fly   196 ECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPS----ETVSKIHLVDLAGSERAN 256
            ..::.||..||.|:||||:.||||||:|.||....::  |:.|    |.|.|:.||||||||||.
  Rat   199 SLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLY--DVKSGTSGEKVGKLSLVDLAGSERAT 261

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            .|||.|.|||||::|||||.|||.||||||:| |.|.|.:.               ::|||||:|
  Rat   262 KTGAAGDRLKEGSNINKSLTTLGLVISALADQ-GAGKNKNK---------------FVPYRDSVL 310

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            ||||||||||||||.|:|.:|||..||.|||||||||:|||:|||...||||.|.::||:||||:
  Rat   311 TWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIINHAVVNEDPNARIIRDLREEV 375

  Fly   387 NKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQ----KSLGLRKSG 447
            .||:..|........|.||...:..:|..||..:|  |.||.:..:.|.||:    :|||:....
  Rat   376 EKLREQLTKAEAMKSPELKDRLEESEKLIQEMTVT--WEEKLRKTEEIAQERQKQLESLGISLQT 438

  Fly   448 VGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSI-FLK 510
            .|:.:..:...|:.::.| ....:.:|.||| .|.|||.:   :|||:|.|.||..:|..| .:.
  Rat   439 SGIKVGDDKCFLVNLNADPALNELLVYYLKE-HTLIGSAN---SQDIQLCGMGILPEHGIIDIMP 499

  Fly   511 GGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSR 575
            .|.|.|.|....:.:||...:..|.|:..||.||.|..:.||.|.|.:..|..::....:..:..
  Rat   500 EGQVMLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEEREASLKN 564

  Fly   576 LSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLN 640
                .||.|.|       |.||.|                  ..|:..|   |....|.|..::.
  Rat   565 ----DSSSEQL-------DADGDS------------------SSEVSSE---INFNFEYAQMEVT 597

  Fly   641 VERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCR 705
            ::.:..:|..::.:..|.::   .|:|:...|:                               |
  Rat   598 MKALGSNDPMQSILSSLEQQ---HEEEKRSALE-------------------------------R 628

  Fly   706 QISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQF 770
            |...::.:|:..:|..|       .|.|:|..:|.:...               |.|......|:
  Rat   629 QRLMYEHELEQLRRRLS-------PERQNCRGVDRLSFH---------------SPSAQQRLRQW 671

  Fly   771 IKDTVRRNNEEIRKLDEQIAEKERILNASTTKIA----KVDETMLEIQAQLERLRLERAE----S 827
            .::.....|..:.:|.|||. |..:|....:.||    |..|..:.:|.....|...|..    |
  Rat   672 AEEREATLNNSLMRLREQIV-KANLLVREASYIAEELDKRTEYKVTLQIPASSLDANRKRGSLLS 735

  Fly   828 EAESQAMRAKKQNM-----KLQ---LGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQSNLSLV 884
            |...|..|..|...     ||:   |..:.:.......|.|.......::..|.|:..|.|.||:
  Rat   736 EPAIQVRRKGKGKQIWSLEKLENRLLDMRDLYQEWKECEEDSPVSRSYFKRADPFYDEQENHSLI 800

  Fly   885 SSPTI--------TEGQQS-PLSNCSCDAEDEAEDTRKDDLSGSSE-ETSRTCTAGPSSGSGSGS 939
            ....:        .:.|.: |:.|            :|.:::|... |..|.          ||:
  Rat   801 GVANVFLETLFYDVKLQYAVPIIN------------QKGEVAGRLHVEVMRL----------SGA 843

  Fly   940 VG--IGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNY----------KQAVRTSDED 992
            :|  |.| |..|:...|.:.:..:..||:....||.....||.::          ::.|..:.|.
  Rat   844 IGERIAG-GDDPTEVSSEKEVQENRLVCMVKILQATGLPQHLCHFVFCKYDFWDQQEPVTVAPEV 907

  Fly   993 TGSCSSCELGRHSDVARPYCPLHSLR-----RKIAAQKALIMKNLETDLNKAQLDEHIADL---- 1048
            ..|.|.........|...:|...|:.     .:..::.||.::.....:|..:.:..:.||
  Rat   908 DTSSSPTSKEPQCMVVFDHCSEFSVNITEDFIEYLSEGALAIEVYGHKMNDPRKNPALWDLGIIQ 972

  Fly  1049 ---QDLQRRYIQMEQEMLQSVQDLE--AHAQCCADE---------------RSGMERQYELASSI 1093
               :.|:.|:.::.:::...||.||  .:.:.|..|               |.|..|:.::....
  Rat   973 AKTRSLRDRWSEVTRKLEFWVQILEQNENGEYCPVEVIAAKDVPTGGIFQLRQGQSRRVQVEVKS 1037

  Fly  1094 MRSSVMSPTSMEESTSQIYSPSMTRSCPSMREF--PEGEHFITIPSFVMRGAGKQTHYEYEVRIA 1156
            ::.|...|. |||...     |:...|..:|..  |:....|              |.|.|...:
  Rat  1038 VQESGTLPL-MEECIL-----SVGIGCVKVRPLRSPKTHENI--------------HEEEEDMDS 1082

  Fly  1157 LPDGKLNILRRYSRFRELHLCMKHCYGAKISALPFPRRELFASNSEPVAKHRR---------RLL 1212
            ..|..|..|||                ..::||...:..|.....:.|:||.:         :||
  Rat  1083 YQDRDLERLRR----------------KWLNALTKRQEYLDQQLQKLVSKHDKTEDDADREAQLL 1131

  Fly  1213 ELYL-----RRLFVVCSK---IPQCP 1230
            |:.|     |...:|.|.   ||..|
  Rat  1132 EMRLTLTEERNAVMVPSAGSGIPGAP 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	187/373 (50%)
		KISc	3..371	CDD:214526	186/372 (50%)
		Kinesin_assoc	370..478	CDD:292801	36/112 (32%)
		FHA	456..555	CDD:238017	34/100 (34%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	25/117 (21%)
Kif13b	NP_998791.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	187/373 (50%)
		KISc	6..360	CDD:214526	186/371 (50%)
		Kinesin_assoc	357..469	CDD:292801	35/113 (31%)
		FHA	447..544	CDD:238017	34/100 (34%)
		KIF1B	756..802	CDD:289208	10/45 (22%)
		C2	<888..>952	CDD:301316	9/63 (14%)
		DUF3585	<1073..1143	CDD:304905	20/99 (20%)
		DUF3694	<1211..1278	CDD:289256
		CAP_GLY	1644..1707	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920