Protein Alignment Klp98A and Kif21a

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_038934809.1
• Gene: Kif21a / 300158
• RGDID: 1305126
• Length: 1677
• Species: Rattus norvegicus
• Alignment Length: 1287
• Identity: 335/1287 - (26%)
• Similarity: 546/1287 - (42%)
• Gaps: 333/1287 - (25%)

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAE 66
            ||::||||:||..::|......:...:...:.::.         .|:|.  .|||||   .||.:
  Rat     8 SSVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVF---------LGKDK--AFTFDY---VFDID 58

  Fly    67 DPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGT-------PNNPGLIPRIC 124
                :.|||:|:.....:::..:|||||.||||||||:|||:| |||       ....|:|.|..
  Rat    59 ----SQQEQIYTQCIEKLIEGCFEGYNATVFAYGQTGAGKTYT-MGTGFDVNIMEEEQGIISRAV 118

  Fly   125 EELFARMRVGQESGTG----------YRTHASYLEIYNERVKDL------LAAQSTGHGLRVREH 173
            :.||..:   :|..|.          ::.:|.:||:|||.|.||      :.|::....:|:.|.
  Rat   119 KHLFKSI---EEKKTSAIKNGVPPPEFKVNAQFLELYNEEVLDLFDTTRDIDAKNKKSNIRIHED 180

  Fly   174 RSLGPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTI----------TFV 228
            .:.|.|...::...|:...|:.:|:..|...||||||.||..||||||||||          |..
  Rat   181 STGGIYTVGVTTRTVNTEPEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQTDA 245

  Fly   229 QAVFMNDMPSET---------VSKIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISA 284
            :.|..|.|.||:         .:|.|.||||||||...|||||:|.|||..||..|:.||:||||
  Rat   246 ENVTDNKMVSESPQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISA 310

  Fly   285 LAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYS 349
            |.::                   |||..::|||||.||.||:|||||||:|||||.:||:|.::.
  Rat   311 LGDK-------------------SKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFM 356

  Fly   350 ETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKLKSMLAGDIHSLQPSLKVLADLQKKE 414
            |||:||:|||||:||.||..||:|...:.|..||.||.:|:                 .:|.:.:
  Rat   357 ETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQ-----------------MELMEYK 404

  Fly   415 AQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTTGVTLYSLKEGE 479
            ..::::.||..|.   ...:..|...|....:.:.|.:.:...             |:.:|:...
  Rat   405 TGKRIIDEEGVES---INDMFHENAMLQTENNNLRVRIKAMQE-------------TVDALRARI 453

  Fly   480 TRIGSEDADVAQDIELAGDG-----------------IRAQHCSIFLKGGVVTLH---------- 517
            |::.||.|:  |.:..||:|                 :||:    .|:...|..:
  Rat   454 TQLVSEQAN--QVLARAGEGNEEISNMIHSYIKEIEDLRAK----LLESEAVNENLRKSLTRATA 512

  Fly   518 --PWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLIT 580
              |:..|....::.::...|:..  :||.|.:.::         .||::...|.:..:.:|.  .
  Rat   513 RSPFFSASSAFSSTILSSDKETI--EIIDLAKKDL---------EKLKRKEKRKKKRLQKLE--E 564

  Fly   581 SSKENLLTCSIYSDEDGASP-YKRPERQYYPQRPMS---------------RDDPELQDE----- 624
            ||:|..   |:...|:.|.| .::.|.:...::..|               .:|.|.:||
  Rat   565 SSREER---SVAGKENNADPDQEKKEEKGVSEKESSEVDVDENQEASDHEDEEDEEEEDEEEDDI 626

  Fly   625 --------------------------------NRKILDTIENALKQLNVERVQMHDQYKTKVRKL 657
                                            .:|::|.:||:.|:|..    :..||:.|:..|
  Rat   627 EGEESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQT----LKKQYEEKLMML 687

  Fly   658 TEEL--IRLEQEEMDGLQLLNCRE--QELIARKDMLLWEK-----NNEKVQIDI-------VCRQ 706
            ..::  .:||::::  ||.|...|  .|..|:|....:||     |.|..::..       :.:.
  Rat   688 QHKIRDTQLERDQV--LQNLGSVESYSEEKAKKVKCEYEKKLHAMNKELQRLQTAQKEHARLLKN 750

  Fly   707 ISAFQTQLDSKKRDFSEY------VAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDSLDL 765
            .|.::.||...::|.:|.      :.|:::|.|:..:|.|        :..|.|:
  Rat   751 QSQYEKQLKKLQQDVTEMKKTKVRLMKQMKEEQEKARLTE--------SRRNREI---------- 797

  Fly   766 FAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIA----KVDETMLEIQAQLERLRLERAE 826
              ||..||. |:.:.::|.|:.|...:|.:|...|.::.    :|.....::..::.| :|..:|
  Rat   798 --AQLKKDQ-RKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTR-KLSSSE 858

  Fly   827 S----------EAESQAMR-AKKQNMKLQLGN-KSMSTSTSTNEADDVSKSDTYETCDTFHTAQS 879
            |          ..|:.|.| ..:|.|::.:.. :::.|.|:........:........|..||:.
  Rat   859 SPTPDAGSSVTSGEADASRPGTQQKMRIPVARVQALPTPTTNGTRKRYQRKGFTGRVFTSKTARM 923

  Fly   880 NLSLVSSPTITE--GQQSPLSNCSCD-----AEDEAEDTRKDDLSGSSEETSRTCTAGPSSGSGS 937
            ...|:.. .:||  .|:..:||...|     .:.|....|::.||...|:.::      .||.|.
  Rat   924 KWQLLER-RVTEIIMQKMTISNMEADMNRLLRQREELTKRREKLSKRREKIAK------ESGEGD 981

  Fly   938 GSVGIGGSGSAPSCTPSSQAIMSDSGVCLDSRNQA-ILQNGHLNNYKQAVRTSDEDTGSCSSCEL 1001
            .:: :..|....|.|.:...|......|     || |:|   :...|:...|.|. |...::|.|
  Rat   982 KNL-VNISEEMESLTANIDYINDSIADC-----QANIMQ---MEEAKEEGETLDV-TAVINACTL 1036

  Fly  1002 GRHSDVARPYCPLHSLRRKI-----AAQKALIMKNLE-----TDLNKA---QLDEHIADLQDLQR 1053
            ..    || |...|.|...|     ||||...:|.||     |::..|   ||..|:  |::...
  Rat  1037 TE----AR-YLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHM--LKEKAE 1094

  Fly  1054 RYIQMEQEMLQSVQDLEAHAQCCADERSGMERQYELASSIMRSSVMSPTSME 1105
            ...:::..:..::|||::..  ..||....|....|.|.....|.:|...|:
  Rat  1095 LNPELDALLGNALQDLDSAP--LEDEEDSSEEDGPLHSPGSEGSTLSSDLMK 1144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	161/410 (39%)
		Kinesin_assoc	370..478	CDD:465047	18/107 (17%)
		FHA_KIF16	449..556	CDD:438760	21/135 (16%)
		SMC_N	624..>864	CDD:481474	59/314 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Kif21a	XP_038934809.1	KISc_KIF4	8..372	CDD:276823	158/404 (39%)
		SCP-1	<389..1040	CDD:114219	140/754 (19%)
		EnvC	642..>853	CDD:443969	48/238 (20%)
		Rcc_KIF21A	938..1019	CDD:410204	21/95 (22%)
		WD40	1342..1655	CDD:238121
		WD40 repeat	1393..1452	CDD:293791
		WD40 repeat	1458..1493	CDD:293791
		WD40 repeat	1498..1542	CDD:293791
		WD40 repeat	1550..1583	CDD:293791
		WD40 repeat	1590..1626	CDD:293791