Protein Alignment Klp98A and Kif28

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_001257314.1
• Gene: Kif28 / 289309
• RGDID: 1559696
• Length: 1034
• Species: Rattus norvegicus
• Alignment Length: 867
• Identity: 280/867 - (32%)
• Similarity: 419/867 - (48%)
• Gaps: 165/867 - (19%)

  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDA-- 65
            |::||||||||:.||.:..:|.::.|..:...:..|     :||  :....||||.:|||.|.
  Rat    16 SVRVAVRVRPFSQREKNSGSQCVISMHARSITIRDP-----KDA--ELVKTFTFDLAYWSHDGFQ 73

  Fly    66 ---------EDP--HFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGL 119
                     .||  .||.|..|:.|:|..::|.|::||||.:.|||||||||:::|:|...|.|:
  Rat    74 KDEDGVLIPSDPTSKFAGQSDVFHDIGRGILDSAWQGYNATLLAYGQTGSGKSYSMIGYGANKGI 138

  Fly   120 IPRICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLS 184
            |||:|||||..:...:|| ...:...|.||||||:::|||:......||||||.:.||.:||.|.
  Rat   139 IPRVCEELFQAIEKQKES-LEAQVMFSMLEIYNEQIRDLLSRTKAPGGLRVREDQRLGFFVEGLK 202

  Fly   185 QHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDL 249
            .....|..:|::.:.:|:..|.|||||||.:|||||.:..|.|.| ||: |......|.|::|||
  Rat   203 WVPCEDSVQIEKLVEQGSKIRMTASTNMNASSSRSHMLIAIRFKQ-VFL-DTALTKQSSINMVDL 265

  Fly   250 AGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYI 314
            |||||..::|:.|.||:||:.:|.||..||:||||||:...|                 |:||:|
  Rat   266 AGSERQRSSGSEGDRLREGSRVNLSLTNLGNVISALADLAMG-----------------KKVLHI 313

  Fly   315 PYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLI 379
            |||||:||.||:.:|||||:|.:||||||||..|.|||||||||.|||.:.|:..:|   ...|:
  Rat   314 PYRDSVLTKLLQSALGGNSRTTLIAALSPADICYEETLSTLRYAERAKKVRNRAVIN---TCPLV 375

  Fly   380 RELREEINKLKSMLA-GDIHSLQPSLKVLADLQ----------KKEAQEKVLTEEWTEKWKVAQS 433
            |..|.| |.|  :|. |...:.:.|....|:.|          .::|:     .||.:::   .:
  Rat   376 RASRAE-NAL--LLGFGGAGAAEHSACFWAEQQLGTWGTWAQLLEQAR-----REWEQQY---MA 429

  Fly   434 ILQEQKSLGLRKSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAG 497
            :.|||:.:.:            :|||:.::.| ..|||..:.:..|...:|...::.   |.|..
  Rat   430 LAQEQQMVKI------------LPHLLNVNEDPQLTGVLKFFIHNGSCEVGRAASNA---ICLQS 479

  Fly   498 DGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRF-NNPAEAAK 561
            .||..:|.|.....|.||:.|....:..||...:....::...|.|:||..:.|.: ..|:|..
  Rat   480 LGISDKHASFTNMDGKVTVAPHITGKVIVNGVPVSSRTKLQHLDRIILGSNSAFLYIGFPSERG- 543

  Fly   562 LRKDLSRSQLD---MSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQD 623
             .:||.|...|   |.|.:....|.:.|.|.|  ..:|.|.|
  Rat   544 -AEDLGRFDYDFFQMERAAAEGVSVDMLGTAS--PGDDQADP----------------------- 582

  Fly   624 ENRKILDTIENALK--QLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIAR- 685
               .||...::.:|  .|.||..||.::.| |..|:..::..|...:..|..|    ::|::.:
  Rat   583 ---SILAVFQDYIKLMPLVVEANQMSEELK-KGLKMELKVKNLASSDSRGCDL----QKEVMVKV 639

  Fly   686 -----KDMLLWEKN---NEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMG 742
                 .::.:|.|.   |.|..::      ..:|..|:|:    ..:||:|.....|..::..:|
  Rat   640 TKQGTHEVWIWSKAKFINRKFLME------ELYQRFLESR----DSHVAQEDDPFWDPVEVLHLG 694

  Fly   743 ------------MKIEEGTP-LNDE------LLLQVSDSLDLFAAQFIKDTVRRNNEEI-RKLDE 787
                        |.:||... ||.|      |.:|::.......|...:|||....|.: :::|.
  Rat   695 SAHVWLQSLAHRMMLEEQVEFLNCEGLEEAVLHIQITPCSPEGWAHGEEDTVIDPLELLGKRIDF 759

  Fly   788 QIAEKERILNASTTKIAKVDET 809
            ||    .|:.....|..|.|.|
  Rat   760 QI----HIVQCLGVKWLKEDAT 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	173/380 (46%)
		Kinesin_assoc	370..478	CDD:465047	25/119 (21%)
		FHA_KIF16	449..556	CDD:438760	26/108 (24%)
		SMC_N	624..>864	CDD:481474	48/217 (22%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Kif28	NP_001257314.1	Motor_domain	15..370	CDD:473979	173/380 (46%)
		FHA_KIF28P	441..538	CDD:438761	26/99 (26%)
		KIF1B	655..693	CDD:463574	9/47 (19%)