DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp98A and KIF4B

DIOPT Version :10

Sequence 1:NP_524532.2 Gene:Klp98A / 43310 FlyBaseID:FBgn0004387 Length:1265 Species:Drosophila melanogaster
Sequence 2:NP_001092763.1 Gene:KIF4B / 285643 HGNCID:6322 Length:1234 Species:Homo sapiens


Alignment Length:1288 Identity:314/1288 - (24%)
Similarity:524/1288 - (40%) Gaps:358/1288 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAEDP 68
            ::||:|.||...:||....|:.:.....:|:::         .|.|.  .||:|:.:      ||
Human    10 VRVALRCRPLVPKEISEGCQMCLSFVPGETQVV---------VGTDK--SFTYDFVF------DP 57

  Fly    69 HFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGT-----PNNP--GLIPRICEE 126
             ...||:|::.....::...::||||.|.||||||||||::|.|.     .|.|  |:|||:.:.
Human    58 -CTEQEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRVIQL 121

  Fly   127 LFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDF 191
            ||  ..:.::|...:....||||||||.:.|||........:.:||....|..:..|::..|...
Human   122 LF--KEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVA 184

  Fly   192 DEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDLAGSERAN 256
            .:...|:.:||..||.|||.||..||||||||||:..|.. .:|......||:||||||||||..
Human   185 LDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRK-KSDKNCSFRSKLHLVDLAGSERQK 248

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            .|.|.|.|||||.:||:.|:.||:|||||                    |..|:..::|||||.|
Human   249 KTKAEGDRLKEGININRGLLCLGNVISAL--------------------GDDKKGSFVPYRDSKL 293

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            |.||:|||||||.|:|||.:||||.|..|||||||||:||:.|.|||.||.|.:...:..|::::
Human   294 TRLLQDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQV 358

  Fly   387 NKLKSM--------LAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLG- 442
            .:|:.:        |.|.|:: :||..:.:.::|.                  ||:::|.:.|. 
Human   359 QQLQVLLLQAHGGTLPGSINA-EPSENLQSLMEKN------------------QSLVEENEKLSR 404

  Fly   443 -LRKSGVGVVLDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQH-- 504
             |.|:                     .|.|...|   |..|.:|..:...:.:|  :.:| ||  
Human   405 CLSKA---------------------AGQTAQML---ERIILTEQVNEKLNAKL--EELR-QHVA 442

  Fly   505 CSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRS 569
            |.:.|:..|.||....|.:   |..:|...:|                                 
Human   443 CKLDLQKLVETLEDQELKE---NVEIICNLQQ--------------------------------- 471

  Fly   570 QLDMSRLSLITSSKENLLTCSI----YSDEDGASPYKRPE----------RQYYPQRPMSRDDPE 620
                    |||...:..:.|:.    .:.|:.|.....||          :....|..||::..|
Human   472 --------LITQLSDETVACTAAAIDTAVEEEAQVETSPETSRSSDAFTTQHALHQAQMSKEVVE 528

  Fly   621 LQDENRKILDTIENALKQLNVERVQMHD--------QYKTKVRKLTEELIRLEQEEMDGLQLLNC 677
            |   |..:      |||:..|.::..:|        ||:..::.|..|:|.|::|          
Human   529 L---NNAL------ALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKE---------- 574

  Fly   678 REQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCG------ 736
             ::||:                     |::...:..::..|  .||:..|.||||:  |      
Human   575 -KEELV---------------------RELQTAKKNVNQAK--LSEHRHKLLQELE--GQIADLK 613

  Fly   737 -KLDEMG--MKIEEGT-----PLNDELLLQVSDSLDLF------AAQF-------------IKDT 774
             ||:|..  :|::|.|     .||.|:.:..:..:.|.      |.:|             :|:.
Human   614 KKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKER 678

  Fly   775 VRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAESEAE-SQAMRAKK 838
            .|:...|:.||:....::..:|...|.:.|..::.:.:...:...:..:|.|:::. .:.:.|:.
Human   679 DRKRQYELLKLERNFQKQSSVLRRKTEEAAAANKRLKDALQKQREVTDKRKETQSHGKEGIAARV 743

  Fly   839 QNMKLQLGNKSMSTSTSTNEA----DDVSKSDTYETCDTFHTAQSNLSLVSSPTITEGQQSPLSN 899
            :|.   |||: :....||.||    :|:                                  |.:
Human   744 RNW---LGNE-IEVMVSTEEAKRHLNDL----------------------------------LED 770

  Fly   900 CSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGV 964
            ....|:|..:...|.:...:.....|.||...|...|                   |.:.|:.  
Human   771 RKILAQDVVQLKEKKESRENPPPKLRKCTFSLSEVHG-------------------QVLESED-- 814

  Fly   965 CLDSRNQAI-----LQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDVARPYCPLHSLRRKIAAQ 1024
            |:..:.:::     |::..:.:.:|.:..::.:.......|  ..:.:....|.|..|..::.:.
Human   815 CITKQIESLETEMELRSAQIADLQQKLLDAESEDRPKQCWE--NIATILEAKCALKYLIGELVSS 877

  Fly  1025 KALIMKNLE----------TDLNKAQLDE--HIADLQ-DLQRRYIQMEQEMLQSVQDLEAHAQCC 1076
            |..:.| ||          .|:.|...:|  |.:::: :||...::|||:..:.|..|.:..|  
Human   878 KIHVTK-LENSLRQSKASCADMQKMLFEEQNHFSEIETELQAELVRMEQQHQEKVLYLVSQLQ-- 939

  Fly  1077 ADERSGMERQYELASSIMRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGEHFITIPSFVMR 1141
              |....|:|.|.::|.....::|....::...:    .|...|...::..:....|.....:::
Human   940 --ESQMAEKQLEKSASEKEQQLVSTLQCQDEELE----KMREVCEQNQQLLQENEIIKQKLILLQ 998

  Fly  1142 GAGKQTHYEYEVRIALPDG--------------KLNILRRYSRFRELHLCMKH 1180
            .|.:|.|...:..:: ||.              |...|.:.....:|..|.:|
Human   999 VASRQKHLPNDTLLS-PDSSFEYIPPKPKPSRVKEKFLEQSMDIEDLKYCSEH 1050

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp98ANP_524532.2 KISc_KIF1A_KIF1B 2..371 CDD:276816 155/373 (42%)
Kinesin_assoc 370..478 CDD:465047 20/117 (17%)
FHA_KIF16 449..556 CDD:438760 19/108 (18%)
SMC_N 624..>864 CDD:481474 57/285 (20%)
PX_KIF16B_SNX23 1131..1259 CDD:132784 11/64 (17%)
KIF4BNP_001092763.1 KISc_KIF4 8..337 CDD:276823 151/367 (41%)
Smc <429..>986 CDD:440809 125/718 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..513 3/18 (17%)
Interaction with PRC1. /evidence=ECO:0000250|UniProtKB:O95239 663..1234 73/459 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..737 2/24 (8%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O95239 793..798 1/4 (25%)
Globular. /evidence=ECO:0000250 1000..1234 10/52 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1030 2/23 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1076
CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000250|UniProtKB:O95239 1086..1144
SET 1086..>1126 CDD:394802
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1122..1143
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1183..1234
Blue background indicates that the domain is not in the aligned region.

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