Protein Alignment Klp98A and Kif27

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_932167.1
• Gene: Kif27 / 246209
• RGDID: 621071
• Length: 1394
• Species: Rattus norvegicus
• Alignment Length: 1357
• Identity: 339/1357 - (24%)
• Similarity: 556/1357 - (40%)
• Gaps: 385/1357 - (28%)

  Fly     4 LKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAEDP 68
            :|||||:||...:|:..:.|:.:....|..:::         .|||  ..||||:.:..
  Rat     6 IKVAVRIRPLLCKEVLHNHQVCVRDIPKTQQII---------IGRD--RVFTFDFVFGK------ 53

  Fly    69 HFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG------TPNNPGLIPRICEEL 127
             .:||::|||.....:|....|||||.||||||||||||:|:.|      .....|:|||..:|:
  Rat    54 -NSTQDEVYSTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHVASVVDGQKGIIPRAIQEI 117

  Fly   128 FARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFD 192
            |  ..:.......::...||:|:|.|.::|||..:::...|.:||.......:....:..|...:
  Rat   118 F--QSISGNPNIDFKIKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECQVDSVE 180

  Fly   193 EIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSE--------TVSKIHLVDL 249
            ::...:..|||.|.|.:|.||:.||||||||||:..|.....:...:        .|||.|.|||
  Rat   181 DVMGLLQVGNAARHTGTTQMNEHSSRSHAIFTISVCQVGKSAEATEDGEWCSHRHIVSKFHFVDL 245

  Fly   250 AGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYI 314
            |||||...||.||:|.||...||..|:.||:|||||    |.....||               ::
  Rat   246 AGSERVTKTGNTGERFKESIQINSGLLALGNVISAL----GDPRRKSS---------------HV 291

  Fly   315 PYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVN-------- 371
            ||||:.:|.||||||||::||:||..:||:..::.|:|::|:|||||:||.||||:|
  Rat   292 PYRDAKITRLLKDSLGGSAKTVMITCVSPSSSDFDESLNSLKYANRARNIRNKPTLNFSPQADRM 356

  Fly   372 --EDTNVKLIRE----------------------------LREEINKLKSMLAGDIHSLQPSLKV 406
              .:..:||:||                            |.|:|.:|:....|....::.:...
  Rat   357 DEMEFEIKLLREALQSHQASISQTSQTASENVPDQNRIHSLEEQIAQLQEECLGYQDCIEQAFAF 421

  Fly   407 LADLQ-----KKEAQEKVLTEEW----TEKWKVAQSILQEQKSLG-----------------LRK 445
            |.||:     .::.|.|:  ::|    .|..|...:.|...:|:|                 |:|
  Rat   422 LVDLKDAVRLNQKQQHKL--QQWFSRTQEVRKAVLTPLPGNQSIGNLEEGPQHVTVLQLKRELKK 484

  Fly   446 SGVGVVLD-----------SEMPHLIGIHNDVTTGVTLYSLKEGE--TRIGSEDADVAQDI---- 493
            ....:..|           .|:...:.:....:.|..: ||||.:  .|:.:|.. :.|.:
  Rat   485 YQCALAADQVVFTQKELELEELRRQMQLMAQESKGHAV-SLKEAQKVNRLQNEKI-IEQQLLVDQ 547

  Fly   494 ---ELA--------------GDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLI------DEPK 535
               |||              |||..|       :......|..|....|  .|.:      |..|
  Rat   548 LSEELAKRSSSMPTSTKESCGDGPDA-------RAPEKRPHTAPFDSHW--GHYVYIPSRQDFKK 603

  Fly   536 QISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSI---YSDEDG 597
            ..|...:..|.:  :|        |..|   :|||:.|..|    ..::.:|.|..   ..|||.
  Rat   604 VCSSSPVYSLDQ--VF--------AGFR---TRSQMLMGHL----EDQDEVLHCQFSDNSDDEDS 651

  Fly   598 ---ASPYKRPERQYYPQRP--------MSRDDPELQDE---NRKI-LDTIENALKQLNVERVQMH 647
               ..|..|.....:.::|        ||....|.|..   |..: :::::.: ::||:::::..
  Rat   652 EGQEKPRVRSRSHSWVKKPGSVCSLVEMSDTQAECQRSYLGNGDLKMESLQES-QELNLQKLRTS 715

  Fly   648 D----QYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCRQIS 708
            :    :.|.|:|:||.. ||::::.:          :|||...|       |.|    .|.||.|
  Rat   716 ELILNKAKQKMRELTIN-IRMKEDLI----------KELIKTGD-------NAK----SVSRQYS 758

  Fly   709 AFQTQLDSK----KRDFSEYVAKELQELQDCGK-LDEMGMKIEEGTPLNDELLLQVSDSLDLFAA 768
            ...|:|:.:    |.:.:| ..|:||||:  || |.::.:|::          ||......:.||
  Rat   759 LKVTKLEHEAEQAKVELTE-TRKQLQELE--GKDLSDVALKVK----------LQKEFRKKMDAA 810

  Fly   769 QFIKDTVRRNNEEIRKL-------DEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAE 826
            :.....:::..::.:||       :::.:|.|:  |....|..||         ||:| || |.|
  Rat   811 KLRVQVLQKKQQDSKKLASLSIQNEKRASELEQ--NVDHLKYQKV---------QLQR-RL-REE 862

  Fly   827 SEAESQA-MRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQSNLSLVSSPTIT 890
            ||.:.|. ...|:...||    |.:..:....|.......||    |.|     ||:....|..:
  Rat   863 SEKKKQLDAEVKRDQQKL----KELQLNAGQGEGLHPKAEDT----DAF-----NLNRRKGPFRS 914

  Fly   891 EGQQSPLSNCSCDAEDEAED--TRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPSCTP 953
            ..|...|.......::|.|.  :::.:|....||..:
  Rat   915 VDQLQKLDEQRKWLDEEVEKVLSQRQELEMLEEELKK---------------------------- 951

  Fly   954 SSQAIMSDSGVCLDSRNQAILQ-NGHLNNYK----QAVRTSDEDTGSCSSCELGRHSDVARPYCP 1013
             .:||:        |:.:|:|| ..||.|.|    ||:.|                 |..:....
  Rat   952 -REAIV--------SKKEALLQEKSHLENKKLRSSQALST-----------------DSLKISAR 990

  Fly  1014 LHSLRRKIAAQKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQMEQEMLQ----SVQDLEAHAQ 1074
            |:.|.::: ::|:|:::|..|: .|.::.|.:   |.|||     |:|.||    ||.:...|.:
  Rat   991 LNLLDQEL-SEKSLLLENSPTE-EKVKISEQV---QALQR-----EREQLQRQRNSVDEKLRHGR 1045

  Fly  1075 CCADE--------RSGMERQYELASSIMRSSVMSPTSMEESTSQIYSPSMTR-----SCPSMREF 1126
            ..:.:        ..|:| ..|.|......|:.:..|..:|:.|..|.|.:.     .|.::.|
  Rat  1046 VLSPKEEHLLFQLEEGIE-ALEAAIEFKNESIQNRQSSLKSSFQNLSQSESNVLEKLVCLNIAE- 1108

  Fly  1127 PEGEHFITIPSFVMRGAGKQTHY---EYEVRIALPDGKLNILRRYSRFRELHLCMKH 1180
                    |.:.:.:...|..:.   |.:.::...:.|:.:|.|.:...||...:::
  Rat  1109 --------IRAILFKYFNKVINLREAERKQQLQNKEMKMKVLERDNMVHELESALEY 1157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	144/380 (38%)
		Kinesin_assoc	370..478	CDD:465047	29/182 (16%)
		FHA_KIF16	449..556	CDD:438760	26/146 (18%)
		SMC_N	624..>864	CDD:481474	60/260 (23%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	8/53 (15%)
Kif27	NP_932167.1	KISc_KIF4	4..342	CDD:276823	139/374 (37%)
		EnvC	352..>554	CDD:443969	34/205 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	551..583		8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..664		5/21 (24%)
		PTZ00121	<721..1286	CDD:173412	124/572 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1267..1340
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1375..1394