DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp98A and KIF13B

DIOPT Version :9

Sequence 1:NP_524532.2 Gene:Klp98A / 43310 FlyBaseID:FBgn0004387 Length:1265 Species:Drosophila melanogaster
Sequence 2:XP_011542759.1 Gene:KIF13B / 23303 HGNCID:14405 Length:1847 Species:Homo sapiens


Alignment Length:1295 Identity:379/1295 - (29%)
Similarity:577/1295 - (44%) Gaps:283/1295 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFD-A 65
            |.:|||||:||.|.||.|:..:.:::::..|..|........:...|.....|.:|:.:||.| :
Human     4 SKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFAYDHCFWSMDES 68

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFAR 130
            ....:|.|:.|:..||.:::..|::|||||:||||||||||::|||||.:.||||||:|..||.|
Human    69 VKEKYAGQDIVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGLFER 133

  Fly   131 MRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQ 195
            .:..:.....::...||:|||||:|:|||..:.:...|:||||..|||||:.||:.||:.:.:|:
Human   134 TQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIE 198

  Fly   196 ECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPS----ETVSKIHLVDLAGSERAN 256
            ..::.||..||.|:||||:.||||||:|.||....::  |:.|    |.|.|:.||||||||||.
Human   199 SLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLY--DVKSGTSGEKVGKLSLVDLAGSERAT 261

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            .|||.|.|||||::|||||.|||.||||||:|:.|.:.:.                ::|||||:|
Human   262 KTGAAGDRLKEGSNINKSLTTLGLVISALADQSAGKNKNK----------------FVPYRDSVL 310

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            ||||||||||||||.|:|.:|||..||.|||||||||:|||:|:|...||||.|.::||:||||:
Human   311 TWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEV 375

  Fly   387 NKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQ----KSLGLRKSG 447
            .||:..|........|.||...:..:|..||..:|  |.||.:..:.|.||:    :|||:....
Human   376 EKLREQLTKAEAMKSPELKDRLEESEKLIQEMTVT--WEEKLRKTEEIAQERQKQLESLGISLQS 438

  Fly   448 VGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKG 511
            .|:.:..:...|:.::.| ....:.:|.||| .|.|||.:   :|||:|.|.||..:||.|.:..
Human   439 SGIKVGDDKCFLVNLNADPALNELLVYYLKE-HTLIGSAN---SQDIQLCGMGILPEHCIIDITS 499

  Fly   512 -GVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSR 575
             |.|.|.|....:.:||...:..|.|:..||.||.|..:.||.|.|.:..|..::          
Human   500 EGQVMLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAERE---------- 554

  Fly   576 LSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLN 640
                              |||                    .||.:::         ||:.:||:
Human   555 ------------------DED--------------------QDPSMKN---------ENSSEQLD 572

  Fly   641 VE-------RVQMHDQYKTKVRKLTEELIRLEQEEMDGLQ-LLNCREQELIARKDMLLWEKNNEK 697
            |:       ..:::..|:....::|.:.:    ...|.:| :||..||:             :|:
Human   573 VDGDSSSEVSSEVNFNYEYAQMEVTMKAL----GSNDPMQSILNSLEQQ-------------HEE 620

  Fly   698 VQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDS 762
            .:...:.||...::.:|:..:|..|       .|.|:|..:|.....               |.|
Human   621 EKRSALERQRLMYEHELEQLRRRLS-------PEKQNCRSMDRFSFH---------------SPS 663

  Fly   763 LDLFAAQFIKDTVRRNNEEIRKLDEQIAEKE---RILNASTTKIAKVDETMLEIQAQLERLRLER 824
            ......|:.::.....|..:.:|.|||.:..   |..|....::.|..|..:.:|.....|...|
Human   664 AQQRLRQWAEEREATLNNSLMRLREQIVKANLLVREANYIAEELDKRTEYKVTLQIPASSLDANR 728

  Fly   825 AE----SEAESQAMR--AKKQNMKLQ-LGNKSMSTSTSTNEADDVSKSDT-----YETCDTFHTA 877
            ..    ||...|..|  ..||...|: |.|:.:.......|..:..:.:.     ::..|.|:..
Human   729 KRGSLLSEPAIQVRRKGKGKQIWSLEKLDNRLLDMRDLYQEWKECEEDNPVIRSYFKRADPFYDE 793

  Fly   878 QSNLSLVSSPTI--------TEGQQS-PLSNCSCDAEDEAEDTRKDDLSGSSE-ETSRTCTAGPS 932
            |.|.||:....:        .:.|.: |:.|            :|.:::|... |..|.      
Human   794 QENHSLIGVANVFLESLFYDVKLQYAVPIIN------------QKGEVAGRLHVEVMRL------ 840

  Fly   933 SGSGSGSVG--IGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNY----------KQA 985
                ||.||  |.| |...:.....:....:..||:....||.....||:::          ::.
Human   841 ----SGDVGERIAG-GDEVAEVSFEKETQENKLVCMVKILQATGLPQHLSHFVFCKYSFWDQQEP 900

  Fly   986 VRTSDEDTGSCSSCELGRHSDVARPYCPLHSLRRKIAAQKALIMKNLETDLNKAQLDEHIAD--- 1047
            |..:.|...|.||.....|..|...:|...|:             |:..|     ..||:::   
Human   901 VIVAPEVDTSSSSVSKEPHCMVVFDHCNEFSV-------------NITED-----FIEHLSEGAL 947

  Fly  1048 --------LQDLQRRYIQMEQEMLQSVQDLEAHAQCCADERSGMERQYELASSIMRSSVMSPTSM 1104
                    :.|.::      ...|..:..::|..:...|..|.:.|:.|....|          :
Human   948 AIEVYGHKINDPRK------NPALWDLGIIQAKTRSLRDRWSEVTRKLEFWVQI----------L 996

  Fly  1105 EESTSQIYSPSMTRSCP----SMREFPEGEHFITIPSFVMRGAGKQTHYEYEVRIALPDGKLNIL 1165
            |::.:..|       ||    |.::.|.|      ..|.:| .|:....:.||:.....|.|.: 
Human   997 EQNENGEY-------CPVEVISAKDVPTG------GIFQLR-QGQSRRVQVEVKSVQESGTLPL- 1046

  Fly  1166 RRYSRFRELHLCMKHCY------GAKISALPFPR-RELFASNSEPVAKHRRRLLELYLRR 1218
                        |:.|.      ..|:..|..|| .|.|....|.:..::.|.|| .|||
Human  1047 ------------MEECILSVGIGCVKVRPLRAPRTHETFHEEEEDMDSYQDRDLE-RLRR 1093

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp98ANP_524532.2 KISc_KIF1A_KIF1B 2..371 CDD:276816 181/373 (49%)
KISc 3..371 CDD:214526 180/372 (48%)
Kinesin_assoc 370..478 CDD:292801 36/112 (32%)
FHA 456..555 CDD:238017 35/100 (35%)
PX_KIF16B_SNX23 1131..1259 CDD:132784 22/95 (23%)
KIF13BXP_011542759.1 KISc_KIF1A_KIF1B 4..360 CDD:276816 181/373 (49%)
KISc 6..360 CDD:214526 180/371 (49%)
Kinesin_assoc 357..469 CDD:292801 35/113 (31%)
FHA 447..544 CDD:238017 35/100 (35%)
RILP-like <610..710 CDD:304877 24/134 (18%)
KIF1B 756..802 CDD:289208 9/45 (20%)
DUF3585 <1099..1143 CDD:304905
DUF3694 <1221..1279 CDD:289256
Jun <1560..1664 CDD:281890
CAP_GLY 1725..1788 CDD:279625
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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