Protein Alignment Klp98A and klp-19

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_499742.1
• Gene: klp-19 / 176750
• WormBaseID: WBGene00002229
• Length: 1083
• Species: Caenorhabditis elegans
• Alignment Length: 1129
• Identity: 287/1129 - (25%)
• Similarity: 466/1129 - (41%)
• Gaps: 258/1129 - (22%)

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEM-ENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDA 65
            :||:|.||.||.|.||....|...::. ||.|..::            :....||||..:  .|.
 Worm     5 ASLRVVVRARPMNGRETKEGASRCVQFYENTKQIVI------------NESATFTFDAVF--ADT 55

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNN-------PGLIPRI 123
            .|     ||.||......::|..:.|:||.|.||||||||||:| |||.:|       .|:|||:
 Worm    56 SD-----QESVYETTALPLLDRIFAGFNATVLAYGQTGSGKTYT-MGTEDNVGTDEMRRGIIPRL 114

  Fly   124 CEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAV 188
            ...||.|: :..|:...:....|..|:|.:.|.|||........:...|....   |.||:...|
 Worm   115 VSALFQRI-MNTEAPESFAVTVSMFEVYGDNVYDLLRPDKVKLNVHGDEKNCT---VVNLTAVPV 175

  Fly   189 SDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDLAGSE 253
            .|.....:.:|.|...||.|.|.||..||||||:||: ||:.....:..|...:|:.||||||||
 Worm   176 IDLKGALKQLAVGCHYRTKAETAMNAMSSRSHAVFTV-FVEKTATAECDSAFSAKLQLVDLAGSE 239

  Fly   254 RANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRD 318
            |...|.|.|.|:|||.:||..|:.|..||:|||                      .:..:||||:
 Worm   240 RLKKTEAEGNRMKEGININGGLLILSQVIAALA----------------------TKQKHIPYRN 282

  Fly   319 SILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELR 383
            |::|.:|:|||||||.|:.:|.:||||.|..|||:|||||:|||.|.|||.||::...:.|..|:
 Worm   283 SVITRVLQDSLGGNSFTVFLACISPADSNSQETLNTLRYADRAKQIKNKPIVNKNPKAEEIAILQ 347

  Fly   384 EEINKLKSMLAGDIHSLQP----------SLKVLADLQKKEAQEKVLTEEWTEK-WKVAQSILQ- 436
            .::.:|:...|.....:.|          |.::|:  .|:|...|  ||:..|: .|.::.|::
 Worm   348 AQLKRLQKENADLKQGIAPAEVRFNDANNSAEILS--LKEEVVRK--TEQLKERAMKQSECIIRM 408

  Fly   437 ---EQKSLGLRKSGV----------GVVLDSEM----------PHLIGIHNDVTTGVTLYSLKEG 478
               .||:..|.:...          ..||:.||          ..::|   |.....||......
 Worm   409 SALTQKNSRLEEDKAKLQSMLTDVRNTVLNEEMLDAAEVVRSIQQVVG---DTEESTTLADDDND 470

  Fly   479 ETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDII 543
            ||.:|.:| |...|.|...:                           :.|.|.|..|||:..|
 Worm   471 ETALGGQD-DTIYDTERLPE---------------------------LQAELDDLEKQIAMKD-- 505

  Fly   544 LLGRTNIFRFNNPAEA---------AKLRKDLSRSQLDMSRLSLITSSKENL------LTCSIYS 593
                      .|..:|         |..:::..::|| :.|:|.:.:....|      :|.:...
 Worm   506 ----------ENRQKALDEQRAFIEAMQQRESEKTQL-VVRISELETEMNKLRQEGKKVTTAAKL 559

  Fly   594 DEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTI---ENALKQLNVERVQMHDQYKTKVR 655
            .|:.....|..|||:...:.:..|..:||:..|::.:|:   |:.||.|..:|:::..:.:.:..
 Worm   560 AEERRQKLKDLERQHAEDKKVLNDMKKLQETRRRMEETLKKTEDELKNLKTQRLRLLREQRAEAS 624

  Fly   656 KLTEELIRLEQEEMDGLQLLNCREQELIARKDM------LLWEKNNEKVQIDIVCRQI------- 707
            |......:.|:|.......|..||.::..:|.|      :|..:..|..:.:...|::
 Worm   625 KFQAFKQKHEREMAQMKSKLQKRENDVAIQKRMTDQKLTVLQMRLTEANRANKTLRELNLKRANR 689

  Fly   708 -------SAFQTQLDSKKR-----DFSEYVAKELQE-----LQDCGKLDEMGM------KIEEGT 749
                   ||.|..::.:..     ..|.::.::|:.     :|:...::.|..      :|....
 Worm   690 KSSPTNASALQNMIEEELEHEMCAQRSHWLCEDLRRQRHDLMQNINTVESMKFEGGKRRRISASA 754

  Fly   750 PLNDELLLQVSDSLDLFAAQ---FIKDTVRRNNEEIRK--LDEQIAEKERILNASTTKI-AKVDE 808
            ..|..::::..:..::...:   |::.::...||||:.  .:|.||..|...|:...|: |::..
 Worm   755 DPNVSVVIEGEEEFEVKRQKELTFLRASLETLNEEIKDSLRNETIAGNEERANSRWEKVPAEMRP 819

  Fly   809 TMLEIQAQLERLRLERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDT 873
            ....:.||  .:...|.|.|.|.:..|.|.: ...::.:|: |......:.|:..::...|....
 Worm   820 AFEAVYAQ--AVAHIRKEIELEFKLARTKSE-FTAKIASKA-SHEEKRKKEDEEMRAKYRELAQC 880

  Fly   874 FHTAQSN--------LSLVSSPTITEG---QQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTC 927
            ...|:|.        |.|:....:.|.   |...|.|..||.|.:.            ::.||..
 Worm   881 LEDAKSGLHEKIAFLLCLIKENRVDENAIQQFESLKNQFCDVEQKV------------KKASRRK 933

  Fly   928 TAGPSSGSGSGSVGIGGSGSAPSCTPSSQA---------IMSDSGVCL-DSRNQAILQNGHL--- 979
            |..          .:||....|....:.:|         :::...|.: |||:|....:..|
 Worm   934 TTN----------FMGGLTPKPELQRNERARRAVKYYGNVVNSEDVTMDDSRHQKRKDHSLLAVE 988

  Fly   980 ------NNYKQAVRTS----DEDT 993
                  :|.|:.|..|    |:||
 Worm   989 MNRTTDDNVKRRVAMSPIKCDDDT 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	146/376 (39%)
		Kinesin_assoc	370..478	CDD:465047	28/142 (20%)
		FHA_KIF16	449..556	CDD:438760	22/116 (19%)
		SMC_N	624..>864	CDD:481474	50/284 (18%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
klp-19	NP_499742.1	KISc	6..326	CDD:276812	140/366 (38%)
		Smc	<339..>650	CDD:440809	70/358 (20%)
		YhaN	489..>919	CDD:443752	83/473 (18%)