DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and klp-6

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_498069.1	Gene:	klp-6 / 175683	WormBaseID:	WBGene00002218	Length:	928	Species:	Caenorhabditis elegans

Alignment Length:	1054	Identity:	313/1054 - (29%)
Similarity:	484/1054 - (45%)	Gaps:	255/1054 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDA-- 65
            |:.|||||||||.||...:.:|::||.:::|.:       |||...::...||:|:||||.|.
Worm     6 SIIVAVRVRPFNDREKTRNCKLVIEMPDEETTV-------IRDPKTNDEKRFTYDHSYWSHDGFS 63

  Fly    66 ---------EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIP 121
                     .|||:|.|.:|:.|||..|:..|:.|||..:||||||||||:::::|..||.|::|
Worm    64 EKKNGYLEPTDPHYADQRRVFEDLGRGVLANAWAGYNCSLFAYGQTGSGKSYSIVGFKNNKGIVP 128

  Fly   122 RICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGH-GLRVREHRSLGPYVENLSQ 185
            .:|||||.::...::....:....|.:|||.|:|:|||::..... ||:||||...|.|||||:.
Worm   129 IVCEELFKQIADNKKKNMQFEVFVSMMEIYCEKVRDLLSSTPPPKGGLKVREHPKNGFYVENLTT 193

  Fly   186 HAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETV-------SK 243
            ..|:.|.||:..|..|...||.|:|.||.||||:|.|..|||      |...|:..       |:
Worm   194 VPVNSFKEIEAKIEEGTKSRTIAATQMNATSSRAHTIVKITF------NQKSSKQAGGTSMKKSE 252

  Fly   244 IHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGAS 308
            |:|||||||||.:|.|..|.|||||..||:||.|||.||.||       |:|..:        .|
Worm   253 INLVDLAGSERQSAAGTEGDRLKEGIVINQSLTTLGRVIKAL-------HDSQKA--------KS 302

  Fly   309 KRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNED 373
            .:...||||||:||.|||::||||||||||||:||||.|:.|||||||:|:|||:|.....|||:
Worm   303 GKKTQIPYRDSVLTCLLKNALGGNSKTIMIAAISPADINFEETLSTLRFADRAKSIKTNAVVNEN 367

  Fly   374 TNVKLIRELREEINKLKSML----AGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSI 434
            ...:.:||||||..:|:|.:    |||     .|.:.:..|:::.|:.:...||..:.|:  |.|
Worm   368 QTERALRELREENLRLQSQIQGGTAGD-----ASNEEIEKLRRQLAENQKEMEEMEKSWQ--QKI 425

  Fly   435 LQEQKSLGLRKSGVGVVLDSE-----MPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDI 493
            .:|...   ..||....::.|     |.||..::.| ..|.|.::.:..||:.:|::.......|
Worm   426 AEEAAK---HASGASEKVEMEAKKKKMCHLWNLNEDPALTNVIVHFIPVGESVVGNKPTSSGNFI 487

  Fly   494 ELAGDGIRAQHCSIFLKG-GVVTLHPWPLAQ---CWVNAHLIDEPKQISQGDIILLGRTNIFRFN 554
            :::|..|..||  :.||. |...:|..|.::   .::|...:....|:.|.|.:..|..:::.||
Worm   488 QMSGLSILPQH--VTLKNDGNNQIHLSPCSEDLDIFINGKPVHGETQLQQNDRVFFGGNHLYVFN 550

  Fly   555 NPAEAAKLRKDLS--RSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRD 617
            ||.:.. :|.|::  .:|.::::..........|          |..               |:.
Worm   551 NPTKKG-IRTDITYENAQAEIAQNHAAALGNRGL----------GGG---------------SKR 589

  Fly   618 DPELQDENRKILDTIE--NAL-----KQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLL 675
            |..|::|....|..::  ||:     :.:..|.|.:..:.:.....|||..:::..
Worm   590 DLILEEELMSTLPLVQRANAMATELGRNVKFEIVLVSPEMRGLTSGLTEIWVKVHN--------- 645

  Fly   676 NCREQELIARKDMLLWEKNNEKVQIDIVCRQISAF--QTQLDSKKRDFSE--------------- 723
                   |:.....||||:          |.::.:  ..::...|:|.||
Worm   646 -------ISEDTYFLWEKS----------RFMNRYYGMQEMYEAKQDGSEDWNMPKERDPFYEPP 693

  Fly   724 ----YVAKELQELQDCGKLDEMGMKIEEGTPLND----EL-LLQVSDSLDLFAAQFIKDTVRRNN 779
                ::|..:..||....|    :.:||..|:.|    |: ||.|..|           ......
Worm   694 DSPVFIASSVVFLQSLAYL----IDVEEQFPIVDLSGQEIGLLTVGLS-----------PCSTTG 743

  Fly   780 EEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAESEAESQAMRAKKQNMKLQ 844
            :|:|  .|.:.:.::::..:.....||          :..:.|.|          |..|.|.|.:
Worm   744 KELR--GEYVEDPDQLIGKNIAFKVKV----------ISAVGLPR----------RILKSNCKYR 786

  Fly   845 -LGNKSMSTSTS-------------------TNE-ADDVSKSDTYETCDTFHTAQ---------S 879
             .|:|.|:|:.:                   |.| ||.::.|:.|   .||...|         :
Worm   787 FFGSKKMTTTATVSGNTPAYGHEETFQFKPVTKEVADYLANSNLY---ITFWGTQRPRGASSRKN 848

  Fly   880 NLSLVSSPTITEG--------------QQSPLSNCSCDA---------EDEAEDTRKDDL--SGS 919
            ::|.:.|....||              :.|...|.|..|         ::|...|||..:  :||
Worm   849 SISTIGSNEAREGPNKAKRVERLVHQAKTSENRNISVKALETVLKGVDDNENRKTRKQSMKKAGS 913

  Fly   920 SEETSRTCTAGPSS 933
            :...||:.:..|.:
Worm   914 TTIKSRSGSKKPKA 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	178/386 (46%)
		KISc	3..371	CDD:214526	178/386 (46%)
		Kinesin_assoc	370..478	CDD:292801	32/117 (27%)
		FHA	456..555	CDD:238017	25/103 (24%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
klp-6	NP_498069.1	KISc_KIF1A_KIF1B	5..365	CDD:276816	178/386 (46%)
		KISc	6..365	CDD:214526	178/386 (46%)
		FliJ	365..448	CDD:280262	25/92 (27%)
		FHA	449..549	CDD:238017	24/101 (24%)
		KIF1B	659..699	CDD:289208	4/39 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820