DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and Kif1c

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_036012244.1	Gene:	Kif1c / 16562	MGIID:	1098260	Length:	1112	Species:	Mus musculus

Alignment Length:	959	Identity:	327/959 - (34%)
Similarity:	487/959 - (50%)	Gaps:	243/959 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSF-DA 65
            :|:||||||||||:||...||:.::.|:...|.::.|: ||     :|....|||||||||. ..
Mouse     4 ASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPK-QS-----KDAPKSFTFDYSYWSHTSV 62

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNNPGLIPRICEELF 128
            |||.||:|:|||.|:|.:::..|:||||.|:|||||||:||::||||  .|...|::|::||:||
Mouse    63 EDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDLF 127

  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193
            :|:.|.|.:...|....||:|||.|||:|||..:|.| .||||||..|||||::||:.||:.:.:
Mouse   128 SRVNVNQSAQLSYSVEVSYMEIYCERVRDLLNPKSRG-SLRVREHPILGPYVQDLSKLAVTSYAD 191

  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVF--MNDMPSETVSKIHLVDLAGSERAN 256
            |.:.:..||..||.|:||||:|||||||:|||.|.|...  :..:.||.||||.||||||||||:
Mouse   192 IADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRSHDQLTGLDSEKVSKISLVDLAGSERAD 256

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            ::||.|.||||||:|||||.|||.||||||:.......|.                :||||||:|
Mouse   257 SSGARGMRLKEGANINKSLTTLGKVISALADLQSKKRKSD----------------FIPYRDSVL 305

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            |||||::|||||:|.|||||||||.||.|||||||||:|.|.|.....:|||.|.:|||||:||:
Mouse   306 TWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAVINEDPNARLIRELQEEV 370

  Fly   387 NKLKSML-------------------AGDI------------------HS--LQPSLKVLADLQ- 411
            .:|:.:|                   .|.:                  |:  |:||....|:.|
Mouse   371 ARLRDLLMAQGLSASALGGLKVEEGSPGGVLPPASSPPAPASPSSPPPHNGELEPSFSPSAEPQI 435

  Fly   412 -KKEAQEKV---------LTEEWTEKWKVAQSILQEQKSL------GLRKSG--VGVVLDSEMPH 458
             .:||.|::         |.|.|.||.:..:::..|:::|      .:|:.|  |||....:.||
Mouse   436 GPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPH 500

  Fly   459 LIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHC---SIFLKGG--VVTLH 517
            |:.::.| :.:...||.:|:|.||:|..|.    ||:|.|..||.|||   ||....|  :|||.
Mouse   501 LVNLNEDPLMSECLLYHIKDGVTRVGQVDV----DIKLTGQFIREQHCLFRSIPQPDGEVMVTLE 561

  Fly   518 PWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKD----------------- 565
            |...|:.:||..|:.||..:..|:.|::|:.::||||:| |.|:|.::
Mouse   562 PCEGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHP-EQARLERERGVPPPPGPPSEPVDWN 625

  Fly   566 -LSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQ---YYPQRPMSRD--------- 617
             ..:..|:...:.:....::.|        :|..:.|::.:.:   ...|:.:.||
Mouse   626 FAQKELLEQQGIDIKLEMEKRL--------QDLENQYRKEKEEADLLLEQQRLVRDTWGPTEPGQ 682

  Fly   618 ----------DPELQDENRKILD---------TIENALKQLNV------------------ERVQ 645
                      |....:|:.:::.         |::|.:|:..:                  .|:|
Mouse   683 YADSDSGEDSDKRSCEESWRLISSLREQLPPTTVQNIVKRCGLPSSGKRRAPRRVYQIPQRRRLQ 747

  Fly   646 --------MHDQYKTKVRKLTEEL----IRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKV 698
                    |.|.....|:::..|:    .|..:.|::.|..|..||
Mouse   748 GKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRE------------------- 793

  Fly   699 QIDIVCRQISAFQTQLDSKK---RDFSEYVAKELQELQDCG-------------KLDEMGMKIEE 747
                :||.....:...|:.:   ||..:.|.:|    :.||             :::::...|::
Mouse   794 ----LCRTYGKPEGPGDAWRAVARDVWDTVGEE----EGCGGGGGGSEEGARGAEVEDLRAHIDK 850

  Fly   748 GTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERIL 796
            .|.:..|:.||.|.          ||      .|::.|.:::...||::
Mouse   851 LTGILQEVKLQNSS----------KD------RELQALRDRMLRMERVI 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	202/373 (54%)
		KISc	3..371	CDD:214526	202/372 (54%)
		Kinesin_assoc	370..478	CDD:292801	42/166 (25%)
		FHA	456..555	CDD:238017	40/104 (38%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Kif1c	XP_036012244.1	KISc_KIF1A_KIF1B	4..355	CDD:276816	202/373 (54%)
		Kinesin_assoc	352..522	CDD:406567	42/169 (25%)
		FHA	499..599	CDD:238017	40/103 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820