DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and Kif1a

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_006529218.1	Gene:	Kif1a / 16560	MGIID:	108391	Length:	1800	Species:	Mus musculus

Alignment Length:	1549	Identity:	428/1549 - (27%)
Similarity:	689/1549 - (44%)	Gaps:	419/1549 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDA- 65
            :|:|||||||||||||:..|::.|::|....|.::.|:      ..::....|:|||||||..:
Mouse     4 ASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPK------QPKETPKSFSFDYSYWSHTSP 62

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNNPGLIPRICEELF 128
            ||.::|:|:|||.|:|.:::..|:||||.|:|||||||:||::||||  ..:..|:||::||:||
Mouse    63 EDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLF 127

  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193
            :|:.........|....||:|||.|||:|||..::.|: ||||||..||||||:||:.||:.:::
Mouse   128 SRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGN-LRVREHPLLGPYVEDLSKLAVTSYND 191

  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVF--MNDMPSETVSKIHLVDLAGSERAN 256
            ||:.:..||..||.|:||||:|||||||:|.|.|.|...  ..::.:|.||||.||||||||||:
Mouse   192 IQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERAD 256

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            :|||.|.||||||:|||||.|||.|||||||...|.:.          |...|:..:||||||:|
Mouse   257 STGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNK----------NKKKKKTDFIPYRDSVL 311

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            ||||:::|||||:|.|:|||||||.||.|||||||||:|||.|.....:|||.|.||||||::|:
Mouse   312 TWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEV 376

  Fly   387 NKLKSML----AGDI------------------HSLQPSLKVLAD-------------------- 409
            .:|:.:|    .|||                  .|...||..|:.
Mouse   377 TRLRDLLYAQGLGDITDTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEE 441

  Fly   410 -LQKKEAQEKV---LTEEWTEKWKVAQSILQEQKSL------GLRKSG--VGVVLDSEMPHLIGI 462
             :::.:..||:   |.|.|.||.:..::|..|:::|      .:|:.|  :||....:.|||:.:
Mouse   442 AIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNL 506

  Fly   463 HND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIF---LKGG---VVTLHPWP 520
            :.| :.:...||.:|:|.||:|.|||:..|||.|:|..|:.:|| ||   .:||   ||||.|..
Mouse   507 NEDPLMSECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHC-IFRSDSRGGGEAVVTLEPCE 570

  Fly   521 LAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSKEN 585
            .|..:||...:.||..:..|:.|::|::::||||:|.:|.:.|:....::.....:....:.:|.
Mouse   571 GADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQREL 635

  Fly   586 LLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLNVERVQMHDQY 650
            |       ::.|....:..|::.          .||:|:.|:..:.....|:|..::       |
Mouse   636 L-------EKQGIDMKQEMEQRL----------QELEDQYRREREEATYLLEQQRLD-------Y 676

  Fly   651 KTKVRKLTEEL-------IRLEQEEMDGLQLLNCREQEL-------------IARKDMLLW---- 691
            ::|:..|.:::       :..|:||.:.......||.||             .:.:| |||
Mouse   677 ESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRD-LLWGNAI 740

  Fly   692 ---EKN------NEKVQIDIVCRQISAF----------QTQLDSKKRDFSE-YVAKELQELQDCG 736
               |.|      .:|||...|....:.:          :...|.:.|.|.. .||.|:|:.::..
Mouse   741 FLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGA 805

  Fly   737 ----KLDEMGMKIEEGTPLNDEL------LLQVSDSL----DLFAAQF-----IKDTVRRNNEEI 782
                .|:::..:::....:.|..      :::..|::    |.|..:|     :..:|.......
Mouse   806 THYWTLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGSSVISGCNSY 870

  Fly   783 RKLDEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAESEAESQAMRAKKQNMKLQLGN 847
            ..|:..::|:...|..|.|..:...:|....:.|    .:...|.|.|.:....::::::
Mouse   871 PLLNTCMSERMAALTPSPTFSSPDSDTTEPAEEQ----SVGEEEEEEEEEEEEEEEEDLE----- 926

  Fly   848 KSMSTSTSTNEADDVSKSDTYETC---DTFHTAQSNLSLVSSPTITEGQQSPLSNC--------- 900
                        |||....|  .|   |.|:......|||....:.      |||.
Mouse   927 ------------DDVFPEHT--LCDGQDPFYDRPPLFSLVGRAFVY------LSNLLYPVPLVHR 971

  Fly   901 -------------------SCDAEDEAED---------TRKDDLSGSSEE--TSRTCTAGPSSGS 935
                               :..|::||.|         |.|........|  .|.:|.....|.|
Mouse   972 VAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRS 1036

  Fly   936 GSGSVG---IGGSGSAPSCTPSSQAIMSDSGVC--------LDSRNQAILQNGHLNNYKQAVRTS 989
            |:....   :.|.|......||:..:  ::..|        :||..:|.| :|.|:.....:|..
Mouse  1037 GTSQEELRIVEGQGQGADAGPSADEV--NNNTCSAVPPEGLMDSPEKAAL-DGPLDTALDHLRLG 1098

  Fly   990 DEDT-------GSCSSCELGRHSDVARPYCPLHSLRRKIAAQKALIMK--------------NLE 1033
            ...|       .|..|.|   ::|:   :|..:.:.|...|.....:|              |:.
Mouse  1099 STFTFRVTVLQASSISAE---YADI---FCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIA 1157

  Fly  1034 TDLNKAQLD----------------EH---------IADLQDLQRRYIQM--------------- 1058
            .::.|:.::                :|         ::.|:..:|.:.::
Mouse  1158 VEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTM 1222

  Fly  1059 ----------EQEMLQ--SVQDLEAHAQ---CCADERSGME--RQYELASSIMRSSVMSPTSMEE 1106
                      :.::|.  .:.:|||:..   ...|.|.||.  ..:.|...|.|.  ::.|.:.|
Mouse  1223 TRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRR--ITVTLLHE 1285

  Fly  1107 STSQI-YSPSMTRSCPSMREFPEGEHFITIPSFV---MRGAG----------------KQTHYEY 1151
            :.|.| :..........:|..||.:..:..|:.:   :..:|                .:|.|::
Mouse  1286 TGSHIRWKEVRELVVGRIRNTPETDEALIDPNILSLNILSSGYVHPAQDDRQFLDSDIPRTFYQF 1350

  Fly  1152 EVRIALPDGKLN---ILRRYSRFRE-------LHLCMKHC-------------YGAKISALPFPR 1193
            |   |..|..::   :|.|.:.:||       .::.|::|             :.::.:.||..|
Mouse  1351 E---AAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPAVITKDFCMVFYSRDAKLPASR 1412

  Fly  1194 --RELFASNS------------------------EP-VAKHRRRLLE---LYLR 1217
              |.||.|.|                        .| :.:.|||:|:   .|:|
Mouse  1413 SIRNLFGSGSLRATEGNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVR 1466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	197/373 (53%)
		KISc	3..371	CDD:214526	197/372 (53%)
		Kinesin_assoc	370..478	CDD:292801	41/162 (25%)
		FHA	456..555	CDD:238017	42/105 (40%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	28/159 (18%)
Kif1a	XP_006529218.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	197/373 (53%)
		Kinesin_assoc	358..524	CDD:374417	41/165 (25%)
		FHA	501..605	CDD:238017	42/104 (40%)
		DUF572	<607..>685	CDD:367968	15/101 (15%)
		KIF1B	814..861	CDD:372100	5/46 (11%)
		DUF3694	1250..1406	CDD:372133	27/160 (17%)
		PH_KIFIA_KIFIB	1681..1783	CDD:269939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810