Protein Alignment Klp98A and Kif13a

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_036013758.1
• Gene: Kif13a / 16553
• MGIID: 1098264
• Length: 1840
• Species: Mus musculus
• Alignment Length: 1524
• Identity: 431/1524 - (28%)
• Similarity: 645/1524 - (42%)
• Gaps: 431/1524 - (28%)

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFD-A 65
            :.:||||||||.|.||::::.:.::|||..:| :|.|...:.:...|.....|.|||.:||.| :
Mouse     4 TKVKVAVRVRPMNRRELELNTKCVVEMEGNQT-VLHPPPSNTKQGERKPPKVFAFDYCFWSMDES 67

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFAR 130
            ....:|.||.|:..||..:::.|::|||||:||||||||||:|:|||.....|||||:|..||.|
Mouse    68 NTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFQR 132

  Fly   131 MRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQ 195
            :.:.|.....::...||:|||||:|:|||..:.:...|:||||:.|||||:.|||.||:.|::|:
Mouse   133 IALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFEDIE 197

  Fly   196 ECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPS----ETVSKIHLVDLAGSERAN 256
            ..::.||..||.|:||||:.||||||:|.|...|.::  |:.|    |.|||:.|||||||||.:
Mouse   198 SLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLY--DLQSGNSGEKVSKVSLVDLAGSERVS 260

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            .|||.|:|||||::|||||.|||.|||:||:|..|             .|.:|   ::|||||:|
Mouse   261 KTGAAGERLKEGSNINKSLTTLGLVISSLADQAAG-------------KGKNK---FVPYRDSVL 309

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            ||||||:|||||:|.|||.:|||..||.|||||||||:|||.|:|...||||.|.|:|||||||:
Mouse   310 TWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEV 374

  Fly   387 NKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKV---LTEEWTEKWKVAQSILQEQ----KSLGLR 444
            .||:..|:.......|.||     :|.|..||:   ||..|.||.:..::|.||:    :|:|:.
Mouse   375 EKLREQLSQAEAMKAPELK-----EKLEESEKLIKELTVTWEEKLRKTEAIAQERQRQLESMGIS 434

  Fly   445 KSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIF 508
            ....|:.:..:..:|:.::.| ....:.:|.||: .||:|   ||.:|||:|.|.||:.:||.|.
Mouse   435 LETSGIKVGDDKCYLVNLNADPALNELLVYYLKD-HTRVG---ADTSQDIQLFGIGIQPEHCEID 495

  Fly   509 LKG-GVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLR---KDLSRS 569
            :.. |.:||.|...|:..||..|:....|:..||.||.|..:.||.|.|..  |.|   ||..|.
Mouse   496 IAADGDITLTPKENARSCVNGTLVCSTTQLWHGDRILWGNNHFFRINLPKR--KRRDWLKDFERE 558

  Fly   570 QLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIEN 634
                      |||.|:        |.|.||.              :..:|:...|    ...:|.
Mouse   559 ----------TSSAEH--------DLDAASE--------------ASSEPDYNYE----FAQMEV 587

  Fly   635 ALKQLN------------------------------VERVQMHDQYKTKVRKLTEELIR-LEQEE 668
            .:|.||                              .:...:|..::   |...:.::: ||::.
Mouse   588 IMKTLNSNGGFPIVSLSAWWSSPWWSYLKILFPLLWFQTKLVHQHWE---RDPVQNVVQVLEKQY 649

  Fly   669 MDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQ 733
            ::        |:.....:..|::|:..|:::     :|:|. :.|..|...|...|.::..|:
Mouse   650 LE--------EKRTALEEQRLMYERELEQLR-----QQLSP-ERQPPSSASDRLAYSSQTAQQ-- 698

  Fly   734 DCGKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQFIK--DTVRRNN---EEIRKL-DEQIAEK 792
                      |:.:.....|||..|   ||.....|.:|  ..||..|   ||:.|| |.|:..:
Mouse   699 ----------KVTQWAEERDELFRQ---SLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTLQ 750

  Fly   793 ERILNASTTK------------------------IAKVDETMLEIQ----------AQLERLRLE 823
            ....|.|..:                        |.|::..:::::          .:.:||..:
Mouse   751 IPAANLSANRKRGAIVSEPAIQARRKGKGTQVWTIEKLENKLIDMRDLYQEWKENVPEAKRLYGK 815

  Fly   824 RAESEAESQAMRAKKQNM---------------KLQLGNKSMS----------------TST--- 854
            |.:...|:|    :..|:               |||.....:|                |.|
Mouse   816 RGDPFYEAQ----ENHNLIGVANVFLECLFCDVKLQYAVPIISQQGEVAGRLHVEVTRITGTIPE 876

  Fly   855 ---STNEADDVSKSDTYETCDT----FHTAQSNLSLVSSPTITEGQQSP--LSN---CSCDAEDE 907
               ..:.:::.|:|.:.|..|:    .|..:   .|.....|.|....|  |||   |.....|:
Mouse   877 RMAEDDSSENSSESGSLEVVDSSGEVIHRVK---KLTCRVIIKEATGLPISLSNFVFCQYTFWDQ 938

  Fly   908 AEDT------RKDDLSGSSEETSRTCTAGP----------------SSG-----------SGSGS 939
            .|.|      ..|..|..|::...|.|...                |.|           :|:||
Mouse   939 CESTVAAPVVDPDVPSPQSKDAQYTVTFSHCKDYVVTVTEEFLEFISDGALAIEVWGHRCAGNGS 1003

  Fly   940 ---------------------------------------------------VGIGG--------- 944
                                                               |..||
Mouse  1004 PIWEVDSLHAKTRTLHDRWNEVTRRIEVWISILELNELGDYAAVELHQAKDVNTGGVFQLRQGHS 1068

  Fly   945 ------------SGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDEDTGSCS 997
                        ||:.|...   :||:|.|..|:.:|:.. ||.| |::|::    .:||.|...
Mouse  1069 RRVQVTVKPVQHSGTLPLMV---EAILSVSIGCVTARSTK-LQRG-LDSYQR----DEEDGGDMD 1124

  Fly   998 S-------CELGRHSDV---ARPYCPLHSLRRKIAAQKALIMKNLETDLNK-AQLDEHIADLQDL 1051
            |       |...|.||.   .|.|  |....:|::.:|    :..|.|:.: |:|.|....|.:.
Mouse  1125 SYQEEDLNCVRERWSDALIKRREY--LDEQIKKVSNKK----EKTEDDMEREARLVEQWVGLTEE 1183

  Fly  1052 QRRYI-------------------QMEQE-----MLQSVQDLEAHAQCCADERSGMER--QYELA 1090
            :...:                   .||..     :..:..||.|:.|......||:..  ..|..
Mouse  1184 RNAVLVPAPGSGIPGAPADWVPPPGMETHIPVLFLDLNADDLSANEQLVGPHASGVNSILPKEHG 1248

  Fly  1091 SSIMRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGEH-FITIPSFVMRGAGKQTHYEYEVR 1154
            |......::..:..|.|.:..:..|:..|....|..|:.|. ::.:.:.|..............|
Mouse  1249 SQFFYLPIIKHSDDEVSATASWDSSVHDSLHLNRVTPQNERIYLIVKTTVQLSHPAAMELVLRKR 1313

  Fly  1155 IALPDGKLNILRRYSRFRELH---LCMKHCYGAK-----ISALPFPRRE--------LFASNSEP 1203
            ||     .||..:.|..:.|.   ..:..||...     :|.:|....|        |.|:.||.
Mouse  1314 IA-----ANIYNKQSFTQSLKRRISLINICYSCGVTYEIVSNIPKATEEIEDRETLALLAARSEN 1373

  Fly  1204 ---------VAKHRRRLLE----LYLRRL 1219
                     :.|:.|.:|:    |.|.||
Mouse  1374 EGTLDGETYIEKYTRGVLQVENILSLERL 1402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	188/373 (50%)
		Kinesin_assoc	370..478	CDD:465047	39/115 (34%)
		FHA_KIF16	449..556	CDD:438760	38/108 (35%)
		SMC_N	624..>864	CDD:481474	54/347 (16%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	24/119 (20%)
Kif13a	XP_036013758.1	KISc_KIF1A_KIF1B	5..359	CDD:276816	188/372 (51%)
		Kinesin_assoc	356..468	CDD:465047	38/116 (33%)
		FHA_KIF13A	446..554	CDD:438781	40/113 (35%)
		SMC_prok_B	<646..>801	CDD:274008	34/183 (19%)
		KIF1B	788..832	CDD:463574	6/47 (13%)
		DUF3694	<1255..1319	CDD:463599	12/68 (18%)