Protein Alignment Klp98A and neb

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_061516333.1
• Gene: neb / 1277915
• VectorBaseID: AGAMI1_013673
• Length: 1234
• Species: Anopheles gambiae
• Alignment Length: 1241
• Identity: 353/1241 - (28%)
• Similarity: 556/1241 - (44%)
• Gaps: 315/1241 - (25%)

  Fly     1 MSSLKVAVRVRPFNSRE-IDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDN----HHDFTFDYSY 60
            :|:||||||:||.:::| ||..|.::....|:        |.....:..||    .|.|.:|:.:
Mosquito   188 ISNLKVAVRIRPLSAKECIDSVANIVRVQNNE--------LYINGGSTADNLGGVEHFFLYDHVF 244

  Fly    61 WSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG---------TPN- 115
            ||.:||||.:.:|..|||.|.:.::|.|:||||.|:||||||||||:::|||         |||
Mosquito   245 WSCNAEDPAYVSQSGVYSSLVHPLLDKAFEGYNTCLFAYGQTGSGKSYSMMGMDLDENYDETPNP 309

  Fly   116 NPGLIPRICEELFARMRV--GQESGTGYRTHA----SYLEIYNERVKDLLA---------AQSTG 165
            :.|:|||.|.|||||:..  ||       .||    ||.|||||::.|||:         ..:.|
Mosquito   310 DAGIIPRFCHELFARINALKGQ-------VHAEVEVSYFEIYNEKIHDLLSVTPSDGVITVSTPG 367

  Fly   166 HG-----LRVREHRSLGPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTI 225
            .|     |:||||...||||.:||.|.|.....::..:|.||:||.||:|.|||.|||||:||::
Mosquito   368 QGAKRAALKVREHPVWGPYVVDLSTHPVDSHTALRNWLAVGNSQRATAATGMNDKSSRSHSIFSV 432

  Fly   226 TFVQAVFMN-------DMPSETV-------SKIHLVDLAGSERANATGATGQRLKEGAHINKSLV 276
            ....|..::       |..|.|.       |||.|||||||||.:.|.|:|.|||||..|||||:
Mosquito   433 VLNLAEIVHSSDTDDGDHASSTASVKQTKRSKISLVDLAGSERVSQTCASGARLKEGVSINKSLL 497

  Fly   277 TLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAAL 341
            |||.||||||:               |...|:   .|||||||:|||||:::|||||:|:|:|.:
Mosquito   498 TLGKVISALAD---------------TKRSAN---TYIPYRDSVLTWLLRENLGGNSRTVMLATI 544

  Fly   342 SPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKL----------KSMLAGD 396
            |||..:..|||:|||||.:|::|:|:..||||.:.::|||||.|:.:|          |.:...:
Mosquito   545 SPASIHLDETLATLRYACQARSIVNRVKVNEDPHDRIIRELRAEVERLQVLRQDYERQKRLSEAN 609

  Fly   397 IHSLQPSLKVLADLQKKEAQEKVLTEE--------------WTEKWKVAQSILQEQKSLGLRKSG 447
            .|. .|..|::.:....:::.:.|.::              |.|:.:.|:.:.:.:..| |::.|
Mosquito   610 QHH-HPPRKIIIETSVDDSEVEALRQQLAETEQELAKAQRSWRERLQEAEDVRRTEMKL-LKRKG 672

  Fly   448 VGVVLDSEM--PHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFL 509
            :.:.|.:|.  |.|:.:..| :.:|..||.:..|..:||...:....||.|.|..:...||||..
Mosquito   673 LALELSAEQKEPCLVNLATDPMLSGTLLYIIPPGTVKIGRPSSLSTPDIVLEGPLVAPNHCSIEN 737

  Fly   510 KGGVVTLHPWPLA--QCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLD 572
            :.|.:.|.|....  :.:||..|:.|.:|:..||.:::|.::.||.:||     |..:.|.:|:.
Mosquito   738 RNGKLFLLPETSTEYETFVNGELVQERRQLFHGDRLVIGGSHYFRISNP-----LCPNKSNTQIM 797

  Fly   573 MSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENAL- 636
            :                                              :.|..:::||...||.|
Mosquito   798 V----------------------------------------------DFQLAHQEILQEQENRLR 816

  Fly   637 KQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLL-------NCREQELIARKDMLLWEKN 694
            ::|:||:       |..:.::..|.:..|||..:.|..|       .|.::.|...|:.||...:
Mosquito   817 RELDVEK-------KAAIARIEAERMAHEQEYEERLASLELEKFKYKCHKELLETEKEALLQSAS 874

  Fly   695 NEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQV 759
            .:..:.|....:.|..:..||.........:|:|::             :|.|.|  ::|.|..:
Mosquito   875 KQNHKCDGRKARPSDVRDSLDLTPSAAESNLAEEIR-------------RIMEHT--SEESLAHI 924

  Fly   760 SDSLDLFAAQFIKDTVRR-----NNEEIRKLDEQIAEKERILNASTTKIAKVDETMLE-IQAQLE 818
            .        ..:|:..:|     .:.|.::  .|:.:.|.|..|....:.:.:..:.| :.|:||
Mosquito   925 Q--------MMVKEASQRCRTVGLDYEFKQ--TQVWQDEGIFRAMINIVDRPNGRIAEWVPARLE 979

  Fly   819 R-LRLERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQSNLS 882
            . |.:.|...:              |...|.........||..|.|.:::. ..|:.::::.:|:
Mosquito   980 YWLGIVRERDD--------------LTADNMFEHFDLVWNEPGDQSANESL-LQDSHNSSRISLN 1029

  Fly   883 LVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDD---LSGSSEETSRTCTAGPSSGSGSGSVGIGG 944
            |.|   :..|:.|.:||........:..|||..   .|..|:.|:....||..|..|.|
Mosquito  1030 LSS---VIRGRNSIVSNPGSPGTATSGSTRKSQGLFKSIFSKPTTSLMPAGEDSERGFG------ 1085

  Fly   945 SGSAPSCTPSS--QAIMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDV 1007
                   .|:|  :|:.:|:    ||.:    :|...||.:....|:.:...:.
Mosquito  1086 -------RPASARKALFTDA----DSND----ENVPSNNQQLPSATASQSKATV----------- 1124

  Fly  1008 ARPYCPLHSLRRKIAAQKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQMEQEMLQSVQDLEAH 1072
                  ||...:|.|        |...||..|.|     .|:.|..:|           ||.:|.
Mosquito  1125 ------LHRFDQKAA--------NYLKDLYGATL-----KLRKLCEKY-----------QDSDAP 1159

  Fly  1073 AQCCADER--SGME-----RQYELASSIMRS------------SVMSPTSMEESTSQIYSPSMTR 1118
            .....:|.  :|.|     .:..|||..:.|            ||::..:::|:|.........|
Mosquito  1160 PTTDGEESLPTGKEGRSSNAEERLASKCLESVADIERSLQTIRSVLADHNIKEATISAMEGEFGR 1224

  Fly  1119 SCPSMR 1124
            :..|:|
Mosquito  1225 TPKSVR 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	185/417 (44%)
		Kinesin_assoc	370..478	CDD:465047	30/134 (22%)
		FHA_KIF16	449..556	CDD:438760	32/111 (29%)
		SMC_N	624..>864	CDD:481474	49/254 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
neb	XP_061516333.1	None