DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and Kif1b

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_038965095.1	Gene:	Kif1b / 117548	RGDID:	621520	Length:	1825	Species:	Rattus norvegicus

Alignment Length:	1372	Identity:	395/1372 - (28%)
Similarity:	619/1372 - (45%)	Gaps:	331/1372 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDA- 65
            :|:|||||||||||||...:::.|::|:...|.::.|:  :.::|.:    .|:|||||||..:
  Rat     4 ASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPK--NPKEAPK----SFSFDYSYWSHTSP 62

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNNPGLIPRICEELF 128
            |||.||:|.:||:|:|.:::..|:||||.|:|||||||:||::||||  ..:..|:||::|||||
  Rat    63 EDPCFASQSRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELF 127

  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193
            .::.........|....||:|||.|||:|||..::.|: ||||||..||||||:||:.||:.:.:
  Rat   128 EKINDNCNEDMSYSVEVSYMEIYCERVRDLLNPKNKGN-LRVREHPLLGPYVEDLSKLAVTSYTD 191

  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVF--MNDMPSETVSKIHLVDLAGSERAN 256
            |.:.:..||..||.|:||||:|||||||:|||.|.|...  ..::.:|.||||.||||||||||:
  Rat   192 IADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSERAD 256

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            :|||.|.||||||:|||||.|||.|||||||...          .|:.:...|:..:||||||:|
  Rat   257 STGAKGTRLKEGANINKSLTTLGKVISALAEVDN----------CTSKSKKKKKTDFIPYRDSVL 311

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            ||||:::|||||:|.|:|||||||.||.|||||||||:|||.|.....:|||.|.||:|||:||:
  Rat   312 TWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEV 376

  Fly   387 NKLKSML----AGDIHSLQPSL--------KVLADLQK--------------------------- 412
            .:||.:|    .|||..:.|.:        |.|.|.|.
  Rat   377 TRLKDLLRAQGLGDIIDIDPLMDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTS 441

  Fly   413 -----------------------------KEAQEKV---------LTEEWTEKWKVAQSILQEQK 439
                                         :||.|::         |.|.|.||.:..::|..|::
  Rat   442 SPSSCSLNSQAGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMERE 506

  Fly   440 SL------GLRKSG--VGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIEL 495
            :|      .:|:.|  :||....:.|||:.::.| :.:...||.:|:|.||:|..||:..|||.|
  Rat   507 ALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVL 571

  Fly   496 AGDGIRAQHCSIFLKGG------VVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFN 554
            :|..|:.:|| ||....      :|||.|...::.:||...:..|.|:..|:.|::|:.::||||
  Rat   572 SGAHIKEEHC-IFRSERNNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFN 635

  Fly   555 NPAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDP 619
            :|.:|                                           |.||:..|......:..
  Rat   636 HPEQA-------------------------------------------RAEREKTPSAETPSEPV 657

  Fly   620 ELQDENRKILDTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIA 684
            :.....|::|:.          :.:.|..:.:.::::: |.|.:.|:||.|           |:.
  Rat   658 DWTFAQRELLEK----------QGIDMKQEMEKRLQEM-EILYKREKEEAD-----------LLL 700

  Fly   685 RKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRD--------------FSEYVAKELQELQDC 735
            .:..|.:|...:.:|..:..|.::|..|:.:.::.:              |.::.:.:...|:|.
  Rat   701 EQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDL 765

  Fly   736 GKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQFIKDTV------RRNNEEIRKLDEQ------ 788
              |....:.::|...::.||..:|.     |....:.||:      .....|:.|..|.
  Rat   766 --LWGNAVYLKEANAISVELKKKVQ-----FQFVLLTDTLYSPVPPELLPTEMGKTHEDRPFPRT 823

  Fly   789 -IAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAESEAESQAMRAKKQNMKLQLGNKSMST 852
             :|.:.:.|....|....:|:  |:.:..|.|...:||.                 ::|:.:...
  Rat   824 VVAVEVQDLKNGATHYWSLDK--LKQRLDLMREMYDRAG-----------------EVGSNAQDD 869

  Fly   853 STSTNEADD-----------VSKSDTYETC-----------DTFHTAQSNLSLVSSPTITEGQQS 895
            |.:|....|           |..|..:..|           .||.||.|:::     .:.:.||.
  Rat   870 SETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDIT-----ELADEQQD 929

  Fly   896 PLSNCSCDAEDEA--EDTRKDDLSGSSEETSRTCTAG--PSSGSGSGSVGIG------GSGSAPS 950
            .:.    |.:|||  :||..|   ..:||.|...:.|  |........:.:|      .:...|.
  Rat   930 AME----DFDDEAFVDDTGSD---AGTEEGSELFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPV 987

  Fly   951 CTPSSQAIMSDSGVC---LDSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDVARPYC 1012
            ......||:|:.|..   |....|||..:....:|...:|.|.....|..: |....||.
  Rat   988 PLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDN-EYFNQSDF----- 1046

  Fly  1013 PLHSLRRKIAAQKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQMEQEMLQSVQDLEAHAQCCA 1077
            |..::.|     ..|.::.|.....:.|..|.|:..:::.|            :.||:..:....
  Rat  1047 PSAAMTR-----SGLSLEELRIVEGQGQSSEVISPPEEVNR------------MNDLDLKSGTLL 1094

  Fly  1078 DERSGME-------RQYELASSI-MRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGEHFIT 1134
            |.:..||       ...:|.|:. .|.:|:..:.:....:.|:       |.........|.|.|
  Rat  1095 DGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIF-------CQFNFLHRHDEAFST 1152

  Fly  1135 IPSFVMRGAGKQTHYEYEVRIALP---------DGKLNILRRYSRFRELHLCMKHCYGAKISALP 1190
            .| ....|.|....:.:...||:.         ..|..:...:..:::..|   |..|.::::.|
  Rat  1153 EP-LKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPL---HLQGQELNSPP 1213

  Fly  1191 FPRRELF 1197
            .|.|..|
  Rat  1214 QPSRRFF 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	197/373 (53%)
		KISc	3..371	CDD:214526	197/372 (53%)
		Kinesin_assoc	370..478	CDD:292801	44/193 (23%)
		FHA	456..555	CDD:238017	37/105 (35%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	15/76 (20%)
Kif1b	XP_038965095.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	197/373 (53%)
		Kinesin_assoc	358..555	CDD:406567	44/196 (22%)
		FHA	532..636	CDD:238017	37/104 (36%)
		KIF1B	845..892	CDD:403579	10/63 (16%)
		DUF3694	1266..1422	CDD:403614
		PH_KIFIA_KIFIB	1710..1808	CDD:269939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920