DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp98A and Kif1c

DIOPT Version :9

Sequence 1:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_665884.2	Gene:	Kif1c / 113886	RGDID:	70928	Length:	1100	Species:	Rattus norvegicus

Alignment Length:	1078	Identity:	358/1078 - (33%)
Similarity:	518/1078 - (48%)	Gaps:	256/1078 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSF-DA 65
            :|:||||||||||:||...||:.::.|:...|.::.|: ||     :|....|||||||||. ..
  Rat     4 ASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPK-QS-----KDAPKSFTFDYSYWSHTSV 62

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNNPGLIPRICEELF 128
            |||.||:|:|||.|:|.:::..|:||||.|:|||||||:||::||||  .|...|::|::||:||
  Rat    63 EDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDLF 127

  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193
            :|:.|.|.:...|....||:|||.|||:|||..:|.| .||||||..|||||::||:.||:.:.:
  Rat   128 SRVNVNQSAQLSYSVEVSYMEIYCERVRDLLNPKSRG-SLRVREHPILGPYVQDLSKLAVTSYAD 191

  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVF--MNDMPSETVSKIHLVDLAGSERAN 256
            |.:.:..||..||.|:||||:|||||||:|||.|.|...  :..:.||.||||.||||||||||:
  Rat   192 IADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRSHDQLTGLDSEKVSKISLVDLAGSERAD 256

  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321
            ::||.|.||||||:|||||.|||.||||||:.......|.                :||||||:|
  Rat   257 SSGARGMRLKEGANINKSLTTLGKVISALADLQSKKRKSD----------------FIPYRDSVL 305

  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386
            |||||::|||||:|.|||||||||.||.|||||||||:|.|.|.....:|||.|.:|||||:||:
  Rat   306 TWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAVINEDPNARLIRELQEEV 370

  Fly   387 NKLKSML-------------------AGDI------------------HS--LQPSLKVLADLQ- 411
            .:|:.:|                   .|.:                  |:  |:||....|:.|
  Rat   371 ARLRELLMAQGLSASALGGLKVEEGSPGGVLPAASSPPAPASPSSPPPHNGELEPSFSPSAEPQI 435

  Fly   412 -KKEAQEKV---------LTEEWTEKWKVAQSILQEQKSL------GLRKSG--VGVVLDSEMPH 458
             .:||.|::         |.|.|.||.:..:::..|:::|      .:|:.|  |||....:.||
  Rat   436 GPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPH 500

  Fly   459 LIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHC---SIFLKGG--VVTLH 517
            |:.::.| :.:...||.:|:|.||:|..|.    ||:|.|..||.|||   ||....|  :|||.
  Rat   501 LVNLNEDPLMSECLLYHIKDGVTRVGQVDV----DIKLTGQFIREQHCLFRSIPQPDGEVMVTLE 561

  Fly   518 PWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSS 582
            |...|:.:||..|:.||..:..|:.|::|:.::||||:| |.|:|.:
  Rat   562 PCEGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHP-EQARLER------------------ 607

  Fly   583 KENLLTCSIYSDEDGASPYKRPERQYYPQRP----------MSRDDPELQDENRKILDTIENALK 637
                        |.|..|...|     |..|          :.:...:::.|..|.|..:||
  Rat   608 ------------ERGVPPPPGP-----PSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLEN--- 652

  Fly   638 QLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDI 702
                       ||            |.|:||.|    |...:|.|.|..|.   .::::|...:.
  Rat   653 -----------QY------------RKEKEEAD----LLLEQQRLYADSDS---GEDSDKRSCEE 687

  Fly   703 VCRQISAFQTQL---------------DSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLN 752
            ..|.||:.:.||               .|.||.....|.:..|..:..||........:......
  Rat   688 SWRLISSLREQLPPNTVQTIVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAV 752

  Fly   753 DELLLQVS--------DSLDLFAAQFIKDTVRRNNEE----------IRKLDEQIAEKERILNA- 798
            .|:..:|:        ..::..||..:::..|...:.          .|.:.:.:.|:|.....
  Rat   753 KEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPEGPGDAWRAVARDVWDTVGEEEGCGGGG 817

  Fly   799 ----STTKIAKVDETMLEIQ---AQLERLRLERAESEAESQAMRAKKQNMKLQLGNKSMSTSTST 856
                ...:.|:|::....|.   ..|:.::|:.:..:.|.||:|.:...|:..:        ..|
  Rat   818 GGGEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDRELQALRDRMLRMERVI--------PLT 874

  Fly   857 NEADDVSKSDTYETCDTFHTAQSNLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSS- 920
            .:.:|.::             :|.|...:.|..:|..:..:||      |.:...|......||
  Rat   875 QDLEDDNE-------------ESGLVTWAPPEGSEAVEEAVSN------DHSPAVRPSSPPQSSW 920

  Fly   921 EETSRTCTAGPSSGSG------------SGSVGIGGSG 946
            |..||.....|:...|            .|..|.||.|
  Rat   921 ERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGSGGRG 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	202/373 (54%)
		KISc	3..371	CDD:214526	202/372 (54%)
		Kinesin_assoc	370..478	CDD:292801	42/166 (25%)
		FHA	456..555	CDD:238017	40/104 (38%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Kif1c	NP_665884.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	202/373 (54%)
		Kinesin_assoc	352..522	CDD:406567	42/169 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..435		6/36 (17%)
		FHA	499..599	CDD:238017	40/103 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	900..924		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	949..1100		5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820