Protein Alignment Klp98A and Kif19b

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_001365608.1
• Gene: Kif19b / 101055939
• MGIID: 3646257
• Length: 974
• Species: Mus musculus
• Alignment Length: 941
• Identity: 258/941 - (27%)
• Similarity: 394/941 - (41%)
• Gaps: 266/941 - (28%)

  Fly     4 LKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRD---AGRDNHHDFTFDYSYWSFDA 65
            |.||:|:||.||.|::..|.:|......:..:|....:...|   |.|.....|.||..:
Mouse    28 LMVALRIRPLNSTELEEGATVIAHKVGDQVVVLMDPGEDPEDTLRAHRSRERTFIFDTVF----- 87

  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFAR 130
             |.| |:||.||......:|:....|||..:||||.:|:|||.||:|....||:..:...:||..
Mouse    88 -DQH-ASQETVYCATIQHLVEGVISGYNTTIFAYGPSGAGKTHTMLGVDAEPGIYLQTLTDLFQA 150

  Fly   131 MRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQ 195
            :...|:: ..|....||||||||.::||| ..|:|. |.:||.......:..:::.:.|:..||.
Mouse   151 IEETQDN-MEYSVSMSYLEIYNEVIRDLL-NPSSGF-LELREDSRGSIQIAGITEVSTSNAQEIM 212

  Fly   196 ECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSET-VSKIHLVDLAGSERANATG 259
            :.:.:||.|||...|..|.|||||||:..:|..|.....|:..|. :.::.:|||||||||..|.
Mouse   213 QLLTKGNRQRTQEPTATNKTSSRSHAVLQVTVHQRSRGGDLAEEVRLGRLFMVDLAGSERAAQTQ 277

  Fly   260 ATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWL 324
            ..|:|:|||||||:||:.||:.|:||:|:.|                  .|..|:.:|||.||.|
Mouse   278 NRGKRMKEGAHINRSLLALGNCINALSEKGG------------------SRAQYVNFRDSKLTRL 324

  Fly   325 LKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNI---INKPTVNEDTNV----KLIREL 382
            |||:|||||:|:|||.:|||..::.|:.:||.||.|||||   :.:..:|....:    .:|.:|
Mouse   325 LKDALGGNSRTVMIAHISPASTSFEESRTTLLYAYRAKNIKTRVKRNLLNVSYRIAQYTDVISDL 389

  Fly   383 REEINKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSG 447
            |.||..|||                    |.|.|:|       ||                 ||.
Mouse   390 RREIGHLKS--------------------KIEKQDK-------EK-----------------KSD 410

  Fly   448 VGVV-LDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKG 511
            .||: :...:||                             |..:|..|..:.||||....|.:
Mouse   411 PGVLDIQVTIPH-----------------------------DAEEDSRLQMNRIRAQLIGAFKE- 445

  Fly   512 GVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQL---DM 573
                       |..:...|::            |..|||          :|..|:||..|   |.
Mouse   446 -----------QMEMRRSLVE------------LENTNI----------ELHIDMSRHLLTIADW 477

  Fly   574 SRLSL-----ITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPEL----QDENRKIL 629
            .|...     :.|.:.:........:|.|||   .|     |:..::|::..|    |.:...:.
Mouse   478 EREKTHQHVDVDSGERDKEPVDADGEEVGAS---EP-----PEVALAREEVNLLLAEQQKTAALK 534

  Fly   630 DTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQE------------- 681
            ..:|..|.....:..||.   |...|::|.|    ||.|:  |||| ||..|
Mouse   535 AGLEQRLAHAKQKASQME---KLLPRQVTSE----EQREV--LQLL-CRAHELEVENTELQADNL 589

  Fly   682 ----LIARKDMLLWEKNNEKVQIDIVCRQISAFQTQL---------DSKKRDFSEYVAKELQELQ 733
                |:.:||.::...:..:    ::|.|:...|.||         :..::.:..| ::||.|
Mouse   590 FRKNLLCQKDFVIQRYHQHR----LLCEQVIQGQRQLMQDNGISAPEPLEQQYRLY-SRELGE-- 647

  Fly   734 DCGKLDEMGMKI--------------------EE--GTPLNDELLLQVSDSLDLFAAQFIKDTVR 776
              |.||.:.:::                    ||  |.||.|...|....:.:|......:|:..
Mouse   648 --GTLDRLLLQLSVMSSSLQDGPIMNVSPPPTEESSGEPLGDRRDLPWGATFELPQMLLERDSDG 710

  Fly   777 RNNEE---IRKLDEQIAEKERILNASTTKI--------------AKVDETMLEIQAQLERLRLER 824
            ..:.:   :|:|.:|    :.:|.....:|              ||...:.|:..|.|| ||.::
Mouse   711 NRSSKSTPLRRLGKQ----DSLLPPPALRILLTPPMLEKPNAPGAKSLISRLQPTAALE-LRTQQ 770

  Fly   825 AESE----AESQAMRAKKQNMKLQLGNKSMS 851
            ...|    ..:||::      ::.||.||::
Mouse   771 PAGEMSPLLSAQALK------EMALGTKSIA 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	144/373 (39%)
		Kinesin_assoc	370..478	CDD:465047	21/112 (19%)
		FHA_KIF16	449..556	CDD:438760	18/107 (17%)
		SMC_N	624..>864	CDD:481474	62/297 (21%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Kif19b	NP_001365608.1	KISc_KIP3_like	27..364	CDD:276821	142/363 (39%)
		PHA03307	675..>974	CDD:223039	29/132 (22%)