Protein Alignment Klp98A and kif5c

DIOPT Version :10

• Sequence 1: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_002935337.3
• Gene: kif5c / 100493873
• XenbaseID: XB-GENE-977474
• Length: 959
• Species: Xenopus tropicalis
• Alignment Length: 1203
• Identity: 291/1203 - (24%)
• Similarity: 467/1203 - (38%)
• Gaps: 311/1203 - (25%)

  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67
            |:||..|.||.|..||....:.|...:.:.|.::.|....:                   ||...
 Frog     8 SIKVMCRFRPLNKAEIQRGDKFIPVFKGEDTVVVGPSKPYV-------------------FDKVF 53

  Fly    68 PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNN---PGLIPRICEELFA 129
            |...|||.|||.....:|....:|||..:||||||.||||.||.|..::   .|:||||..::|.
 Frog    54 PSNTTQEHVYSACAKQIVKDVLDGYNGTIFAYGQTSSGKTHTMEGKLHDHQMMGIIPRIAHDIFD 118

  Fly   130 RMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEI 194
            .: ...:....:....||.|||.::::|||....|  .|.|.|.::..|:|:..::..||..:|:
 Frog   119 HI-YSMDENLEFHIKVSYFEIYLDKIRDLLDVSKT--NLAVHEDKNRVPFVKGCTERFVSSPEEV 180

  Fly   195 QECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVS-KIHLVDLAGSERANAT 258
            .:.|..|.|.|..|.||||:.|||||:||.|...|.   |....:.:| |::||||||||:.:.|
 Frog   181 MDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQE---NVETEKKLSGKLYLVDLAGSEKVSKT 242

  Fly   259 GATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTW 323
            ||.|..|.|..:|||||..||:|||||||.|                     ..::|||||.:|.
 Frog   243 GAEGAVLDEAKNINKSLSALGNVISALAEGT---------------------KTHVPYRDSKMTR 286

  Fly   324 LLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINK 388
            :|:||||||.:|.:|...||:..|.:||.|||.:..|||.|.|..:||        .||..|
 Frog   287 ILQDSLGGNCRTTIIICCSPSIFNEAETKSTLMFGQRAKTIKNTVSVN--------LELTAE--- 340

  Fly   389 LKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQE-QKSLGLRKSGVGVVL 452
                                :.:||..:||       :|.|..::|:|. :..|...:.|..|.:
 Frog   341 --------------------EWKKKYEKEK-------DKTKSLKNIIQHLEMELNRWRRGEAVPV 378

  Fly   453 DSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLH 517
            |.:.                 |.|:.:|
 Frog   379 DEQT-----------------SAKDQKT------------------------------------- 389

  Fly   518 PWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSR--SQLD------MS 574
               |..|       |....|..|   |:|.|||    :..|..|..:|::.  .|||      ..
 Frog   390 ---LEPC-------DNTPVIDNG---LVGATNI----SSEEKKKYDEDIASLYGQLDDKDDEINQ 437

  Fly   575 RLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQL 639
            :..||...|:.:|                             |..||....|:..:.|:..|.:|
 Frog   438 QSQLIEKLKQQML-----------------------------DQEELLASTRRDYEKIQEELTRL 473

  Fly   640 NVERVQMHDQYKTKVRKLTEELIRLEQ--EEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDI 702
            .:|.....|:.|..::.|.|..:..:|  :|::....||          :.|..|...:...:.:
 Frog   474 QIENDAAKDEVKEVLQALEELAVNYDQKSQEVEDKTKLN----------EQLSEELTQKTTNLTV 528

  Fly   703 VCRQISAFQTQLDSKKRDFSEYVAKELQELQDCG---------KLDEMGMKIEEG--------TP 750
            ..|::|..|...:.:::..:|.:...|::|.:.|         .|.|:...|||.        :.
 Frog   529 TQRELSQLQELSNHQRKRTTEILNLLLKDLGEIGGIVGTNDVKTLAEVNGVIEEEFTMARLYISK 593

  Fly   751 LNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQA 815
            :..|:...|:.|..|.:||.      ..|.:|...::::|..:.:.:....||..:.:.|..::.
 Frog   594 MKSEVKSLVNRSKQLESAQI------EANRKINASEKELAACQLLSSQHEAKIKSLTDYMQNMEQ 652

  Fly   816 QLERLRLERAESEAESQAMR--AKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQ 878
            :  |.:||.|:.....:..|  |:::..|:...:|.....|...:|:::.|  |.|.....|
 Frog   653 R--RRQLEEAQDALNEELARLHAQEKMHKVSFQDKEKEHLTRLQDAEEIKK--TLEQQMESH--- 710

  Fly   879 SNLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTRK--DDLSGSSEETSRTCTAGPSSGSGSGSVG 941
                       .|..|..||.    ..||.|:.:|  |||...:::...
 Frog   711 -----------REAHQKQLSR----LRDEIEEKQKMIDDLKDLNQKLQL---------------- 744

  Fly   942 IGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSD 1006
                 .....|...:.:.::     :.:.:..||...|.|.|:  ..|.||.       .|....
 Frog   745 -----QLDKLTSDYEKLKTE-----EEQREEDLQKLVLLNEKR--EQSREDL-------KGLEET 790

  Fly  1007 VARPYCPLHSLRRKIAAQKAL-IMKNLETDLNK-----AQ------LDEHIADLQDLQRRYIQME 1059
            |||....||:||:......|| :.|.:|.|.:.     ||      |:.::..|..:.::.::..
 Frog   791 VARELQTLHNLRKLFIQDLALRVQKRVELDSDNGGGSAAQKQKISFLENNLEQLTKVHKQLVRDN 855

  Fly  1060 QEMLQSVQDLEAHAQCCADERSGMERQY-ELASSIMRSSVMSPTSMEESTSQIYSPSMTRSCPS- 1122
            .::...:..||...:..|:....:|... |...:.||........::.....:.:.::.|..||
 Frog   856 ADLRCELPKLEKRLRATAERVKALEGALKEAKENAMRDRRRYQQEVDRIKEAVRAKNIARRAPSA 920

  Fly  1123 --MREFPEGEHFITIPSFV--MRGAGKQTHYEY 1151
              .:....|.:..:.|:.|  :||.|..||..|
 Frog   921 QIAKPIRPGHYPASSPTAVHSIRGGGGSTHSSY 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	139/371 (37%)
		Kinesin_assoc	370..478	CDD:465047	19/108 (18%)
		FHA_KIF16	449..556	CDD:438760	15/106 (14%)
		SMC_N	624..>864	CDD:481474	49/260 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	8/23 (35%)
kif5c	XP_002935337.3	KISc_KHC_KIF5	6..327	CDD:276820	137/364 (38%)
		EnvC	452..>676	CDD:443969	47/241 (20%)
		SMC_prok_B	580..>912	CDD:274008	73/394 (19%)
		Khc_CBD_cc	836..905	CDD:467880	9/68 (13%)